Effect of nicardipine on haemodynamic and bispectral index changes following endotracheal intubation

Jae Hwan Kim, Yoon Sook Lee, Woon Young Kim, M. S. Chang, J. Y. Park, Hye Won Shin, Young Cheol Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We investigated the effect of IV nicardipine on haemodynamic and bispectral index responses to the induction of general anaesthesia and intubation. Forty patients were randomly allocated to two groups of 20 to receive normal saline or nicardipine 15 μg/kg IV 30 s after induction. Ninety seconds later, tracheal intubation was performed. Systolic blood pressure, heart rate and bispectral index were measured at baseline, 1 min after induction, preintubation, and every minute until 5 min after endotracheal intubation. Rate-pressure product values were calculated. In the nicardipine group, systolic blood pressure decreased compared with the control group, and heart rate increased compared with the control group. Bispectral index and rate-pressure product showed no differences between the two groups. In conclusion, the administration of 15 μg/kg nicardipine IV does not affect anaesthetic depth in response to the induction of general anaesthesia and intubation.

Original languageEnglish
Pages (from-to)52-58
Number of pages7
JournalJournal of International Medical Research
Volume35
Issue number1
DOIs
Publication statusPublished - 2007 Jan 1

Fingerprint

Nicardipine
Intratracheal Intubation
Hemodynamics
Intubation
Blood Pressure
Blood pressure
General Anesthesia
Heart Rate
Pressure
Control Groups
Anesthetics

Keywords

  • Bispectral index
  • Endotracheal intubation
  • Nicardipine

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

Effect of nicardipine on haemodynamic and bispectral index changes following endotracheal intubation. / Kim, Jae Hwan; Lee, Yoon Sook; Kim, Woon Young; Chang, M. S.; Park, J. Y.; Shin, Hye Won; Park, Young Cheol.

In: Journal of International Medical Research, Vol. 35, No. 1, 01.01.2007, p. 52-58.

Research output: Contribution to journalArticle

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