Abstract
We investigated the effect of IV nicardipine on haemodynamic and bispectral index responses to the induction of general anaesthesia and intubation. Forty patients were randomly allocated to two groups of 20 to receive normal saline or nicardipine 15 μg/kg IV 30 s after induction. Ninety seconds later, tracheal intubation was performed. Systolic blood pressure, heart rate and bispectral index were measured at baseline, 1 min after induction, preintubation, and every minute until 5 min after endotracheal intubation. Rate-pressure product values were calculated. In the nicardipine group, systolic blood pressure decreased compared with the control group, and heart rate increased compared with the control group. Bispectral index and rate-pressure product showed no differences between the two groups. In conclusion, the administration of 15 μg/kg nicardipine IV does not affect anaesthetic depth in response to the induction of general anaesthesia and intubation.
| Original language | English |
|---|---|
| Pages (from-to) | 52-58 |
| Number of pages | 7 |
| Journal | Journal of International Medical Research |
| Volume | 35 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2007 Jan 1 |
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Keywords
- Bispectral index
- Endotracheal intubation
- Nicardipine
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Biochemistry, medical
Cite this
Effect of nicardipine on haemodynamic and bispectral index changes following endotracheal intubation. / Kim, Jae Hwan; Lee, Yoon Sook; Kim, Woon Young; Chang, M. S.; Park, J. Y.; Shin, Hye Won; Park, Young Cheol.
In: Journal of International Medical Research, Vol. 35, No. 1, 01.01.2007, p. 52-58.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of nicardipine on haemodynamic and bispectral index changes following endotracheal intubation
AU - Kim, Jae Hwan
AU - Lee, Yoon Sook
AU - Kim, Woon Young
AU - Chang, M. S.
AU - Park, J. Y.
AU - Shin, Hye Won
AU - Park, Young Cheol
PY - 2007/1/1
Y1 - 2007/1/1
N2 - We investigated the effect of IV nicardipine on haemodynamic and bispectral index responses to the induction of general anaesthesia and intubation. Forty patients were randomly allocated to two groups of 20 to receive normal saline or nicardipine 15 μg/kg IV 30 s after induction. Ninety seconds later, tracheal intubation was performed. Systolic blood pressure, heart rate and bispectral index were measured at baseline, 1 min after induction, preintubation, and every minute until 5 min after endotracheal intubation. Rate-pressure product values were calculated. In the nicardipine group, systolic blood pressure decreased compared with the control group, and heart rate increased compared with the control group. Bispectral index and rate-pressure product showed no differences between the two groups. In conclusion, the administration of 15 μg/kg nicardipine IV does not affect anaesthetic depth in response to the induction of general anaesthesia and intubation.
AB - We investigated the effect of IV nicardipine on haemodynamic and bispectral index responses to the induction of general anaesthesia and intubation. Forty patients were randomly allocated to two groups of 20 to receive normal saline or nicardipine 15 μg/kg IV 30 s after induction. Ninety seconds later, tracheal intubation was performed. Systolic blood pressure, heart rate and bispectral index were measured at baseline, 1 min after induction, preintubation, and every minute until 5 min after endotracheal intubation. Rate-pressure product values were calculated. In the nicardipine group, systolic blood pressure decreased compared with the control group, and heart rate increased compared with the control group. Bispectral index and rate-pressure product showed no differences between the two groups. In conclusion, the administration of 15 μg/kg nicardipine IV does not affect anaesthetic depth in response to the induction of general anaesthesia and intubation.
KW - Bispectral index
KW - Endotracheal intubation
KW - Nicardipine
UR - http://www.scopus.com/inward/record.url?scp=33947605241&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947605241&partnerID=8YFLogxK
U2 - 10.1177/147323000703500105
DO - 10.1177/147323000703500105
M3 - Article
C2 - 17408055
AN - SCOPUS:33947605241
VL - 35
SP - 52
EP - 58
JO - Journal of International Medical Research
JF - Journal of International Medical Research
SN - 0300-0605
IS - 1
ER -