Effect of nicardipine on renal function following robot-assisted laparoscopic radical prostatectomy in patients with pre-existing renal insufficiency

Hyub Huh, Na Young Kim, Seol Ju Park, Jang Eun Cho

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To investigate the renoprotective effect of nicardipine in patients with pre-existing renal insufficiency undergoing robot-assisted laparoscopic radical prostatectomy (RALRP). Methods: Men with preoperative renal insufficiency (estimated glomerular filtration rate [eGFR] >60 ml/min per 1.73m2) were enrolled and randomized to receive either 0.5 μg/kg per min nicardipine continuous infusion (nicardipine group) or normal saline (control group) during RALRP. Renal function was determined by eGFR and serum creatinine concentration. Results: Serum creatinine levels on postoperative days (POD) 1 and 3 were significantly lower than baseline values in the nicardipine group (n=50). In the control group (n=50), eGFR was significantly higher on POD 3 than baseline, and was significantly higher than baseline on POD 1 and 3 in the nicardipine group. The change in eGFR from baseline to POD 1 was significantly higher in the nicardipine group than the control group. Conclusion: Continuous infusion of nicardipine during RALRP improved postoperative renal function on POD 1 in patients with pre-existing renal insufficiency.

Original languageEnglish
Pages (from-to)427-435
Number of pages9
JournalJournal of International Medical Research
Volume42
Issue number2
DOIs
Publication statusPublished - 2014 Apr

Keywords

  • Nicardipine
  • renal insufficiency
  • robot-assisted surgery

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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