Effect of pedunculagin investigated by non-invasive evaluation on atopic-like dermatitis in NC/Nga mice

Onseok Lee, Myeunghun Choi, Seunghan Ha, Gunwoo Lee, Jaeyoung Kim, Gyuman Park, Minwon Lee, Youngwook Choi, Mingi Kim, Chil Hwan Oh

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10 Citations (Scopus)

Abstract

Background/purpose: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder that is becoming increasingly prevalent. Experimental animal models have been an indispensable tool for studying its pathological mechanisms and for in vivo testing of novel therapeutic approaches. AD-like lesions can be induced experimentally in NC/Nga mice. Pedunculagin, an ellagitannin purified from the Manchurian alder, Alnus hirsuta var. microphylla, Betulaceae, is a novel immunomodulator. To evaluate the effect of pedunculagin for AD-like lesions in NC/Nga mice, using clinical and non-invasive methods. Methods: AD-like lesions were induced in NC/Nga mice using 2,4,6-trinitrochlorobenzene (TNCB). A cream containing 0.1% or 0.5% pedunculagin was applied to the positive treatment group, and the base cream without pedunculagin was applied to the negative treatment group. The control group did not receive any kind of topical agents. We evaluated the therapeutic efficacy of pedunculagin for AD by statistical evaluation of the clinical severity score using non-invasive biomedical engineering tools before treatment, and 1 day, 3 days, 1 week, 2 weeks and 4 weeks afterwards. Results: An AD-like skin rash was successfully induced using TNCB in NC/Nga mice. The group receiving higher concentrations of pedunculagin showed faster and greater improvement. Conclusion: Our results suggest that remedies made from natural materials like pedunculagin are now showing promise for medical applications, and many new studies are expected to explore this potential.

Original languageEnglish
Pages (from-to)371-377
Number of pages7
JournalSkin Research and Technology
Volume16
Issue number3
DOIs
Publication statusPublished - 2010 Jan 1

Keywords

  • 2,4,6-trinitrochlorobenzene
  • Atopic dermatitis
  • NC/Nga
  • Pedunculagin
  • Stereoimage optical topometer

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Lee, O., Choi, M., Ha, S., Lee, G., Kim, J., Park, G., Lee, M., Choi, Y., Kim, M., & Oh, C. H. (2010). Effect of pedunculagin investigated by non-invasive evaluation on atopic-like dermatitis in NC/Nga mice. Skin Research and Technology, 16(3), 371-377. https://doi.org/10.1111/j.1600-0846.2010.00443.x