Effect of pedunculagin investigated by non-invasive evaluation on atopic-like dermatitis in NC/Nga mice

Onseok Lee, Myeunghun Choi, Seunghan Ha, Gunwoo Lee, Jaeyoung Kim, Gyuman Park, Minwon Lee, Youngwook Choi, Mingi Kim, Chil Hwan Oh

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Background/purpose: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder that is becoming increasingly prevalent. Experimental animal models have been an indispensable tool for studying its pathological mechanisms and for in vivo testing of novel therapeutic approaches. AD-like lesions can be induced experimentally in NC/Nga mice. Pedunculagin, an ellagitannin purified from the Manchurian alder, Alnus hirsuta var. microphylla, Betulaceae, is a novel immunomodulator. To evaluate the effect of pedunculagin for AD-like lesions in NC/Nga mice, using clinical and non-invasive methods. Methods: AD-like lesions were induced in NC/Nga mice using 2,4,6-trinitrochlorobenzene (TNCB). A cream containing 0.1% or 0.5% pedunculagin was applied to the positive treatment group, and the base cream without pedunculagin was applied to the negative treatment group. The control group did not receive any kind of topical agents. We evaluated the therapeutic efficacy of pedunculagin for AD by statistical evaluation of the clinical severity score using non-invasive biomedical engineering tools before treatment, and 1 day, 3 days, 1 week, 2 weeks and 4 weeks afterwards. Results: An AD-like skin rash was successfully induced using TNCB in NC/Nga mice. The group receiving higher concentrations of pedunculagin showed faster and greater improvement. Conclusion: Our results suggest that remedies made from natural materials like pedunculagin are now showing promise for medical applications, and many new studies are expected to explore this potential.

    Original languageEnglish
    Pages (from-to)371-377
    Number of pages7
    JournalSkin Research and Technology
    Volume16
    Issue number3
    DOIs
    Publication statusPublished - 2010 Jan 1

    Keywords

    • 2,4,6-trinitrochlorobenzene
    • Atopic dermatitis
    • NC/Nga
    • Pedunculagin
    • Stereoimage optical topometer

    ASJC Scopus subject areas

    • Dermatology

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