Abstract
Background Recent studies have shown the efficacy of terlipressin on postoperative renal function in patients who have undergone living donor liver transplantation (LDLT). Objectives To evaluate the effect of perioperative terlipressin on postoperative renal function in patients who have undergone LDLT and to analyze the hemodynamic data during transplantation surgery. Study Design A meta-analysis. Methods We assessed the postoperative peak serum creatinine level and changes in the hemodynamic data (e.g. The mean arterial pressure, heart rate, and systemic vascular resistance). We collected randomized controlled trials from PubMed, EMBASE Drugs and Pharmacology, Cochrane Controlled Trials Register, and Cochrane Database on Systematic Reviews. Analysis was conducted using RevMan 5.2. Data from each trial were pooled and weighted by their mean differences and corresponding 95% confidence intervals (CI). A heterogeneity assessment was performed. Results Three trials (151 patients) were included. The difference in the mean (95% CI) peak serum creatinine (mg/dL) levels postoperatively was not significant between the intervention and control groups (weighted mean difference [WMD]: -0.27; CI: -0.55-0.01; P =.06). Terlipressin significantly decreased heart rate during the anhepatic phase (WMD: -6.58; 95% CI: -8.85 to -4.31; P <.00001) with a low heterogeneity (I2 = 41%) and significantly decreased heart rate during the neohepatic phase (WMD: -9.82; 95% CI: -11.96 to -7.68; P <.00001), although the heterogeneity was high (I2 > 50%). Conclusions An intravenous infusion of terlipressin perioperatively for LDLT has no effect on the creatinine values postoperatively. Larger randomized controlled trials on terlipressin infusions during liver transplantation are needed.
| Original language | English |
|---|---|
| Pages (from-to) | 1917-1925 |
| Number of pages | 9 |
| Journal | Transplantation Proceedings |
| Volume | 47 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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ASJC Scopus subject areas
- Surgery
- Transplantation
Cite this
Effect of Perioperative Terlipressin on Postoperative Renal Function in Patients Who Have Undergone Living Donor Liver Transplantation : A Meta-Analysis of Randomized Controlled Trials. / won, young ju; Kim, H. J.; Lim, Byung Gun; Ahn, Hyeong Sik; Hwang, M. H.; Lee, Il Ok.
In: Transplantation Proceedings, Vol. 47, No. 6, 01.01.2015, p. 1917-1925.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Effect of Perioperative Terlipressin on Postoperative Renal Function in Patients Who Have Undergone Living Donor Liver Transplantation
T2 - A Meta-Analysis of Randomized Controlled Trials
AU - won, young ju
AU - Kim, H. J.
AU - Lim, Byung Gun
AU - Ahn, Hyeong Sik
AU - Hwang, M. H.
AU - Lee, Il Ok
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background Recent studies have shown the efficacy of terlipressin on postoperative renal function in patients who have undergone living donor liver transplantation (LDLT). Objectives To evaluate the effect of perioperative terlipressin on postoperative renal function in patients who have undergone LDLT and to analyze the hemodynamic data during transplantation surgery. Study Design A meta-analysis. Methods We assessed the postoperative peak serum creatinine level and changes in the hemodynamic data (e.g. The mean arterial pressure, heart rate, and systemic vascular resistance). We collected randomized controlled trials from PubMed, EMBASE Drugs and Pharmacology, Cochrane Controlled Trials Register, and Cochrane Database on Systematic Reviews. Analysis was conducted using RevMan 5.2. Data from each trial were pooled and weighted by their mean differences and corresponding 95% confidence intervals (CI). A heterogeneity assessment was performed. Results Three trials (151 patients) were included. The difference in the mean (95% CI) peak serum creatinine (mg/dL) levels postoperatively was not significant between the intervention and control groups (weighted mean difference [WMD]: -0.27; CI: -0.55-0.01; P =.06). Terlipressin significantly decreased heart rate during the anhepatic phase (WMD: -6.58; 95% CI: -8.85 to -4.31; P <.00001) with a low heterogeneity (I2 = 41%) and significantly decreased heart rate during the neohepatic phase (WMD: -9.82; 95% CI: -11.96 to -7.68; P <.00001), although the heterogeneity was high (I2 > 50%). Conclusions An intravenous infusion of terlipressin perioperatively for LDLT has no effect on the creatinine values postoperatively. Larger randomized controlled trials on terlipressin infusions during liver transplantation are needed.
AB - Background Recent studies have shown the efficacy of terlipressin on postoperative renal function in patients who have undergone living donor liver transplantation (LDLT). Objectives To evaluate the effect of perioperative terlipressin on postoperative renal function in patients who have undergone LDLT and to analyze the hemodynamic data during transplantation surgery. Study Design A meta-analysis. Methods We assessed the postoperative peak serum creatinine level and changes in the hemodynamic data (e.g. The mean arterial pressure, heart rate, and systemic vascular resistance). We collected randomized controlled trials from PubMed, EMBASE Drugs and Pharmacology, Cochrane Controlled Trials Register, and Cochrane Database on Systematic Reviews. Analysis was conducted using RevMan 5.2. Data from each trial were pooled and weighted by their mean differences and corresponding 95% confidence intervals (CI). A heterogeneity assessment was performed. Results Three trials (151 patients) were included. The difference in the mean (95% CI) peak serum creatinine (mg/dL) levels postoperatively was not significant between the intervention and control groups (weighted mean difference [WMD]: -0.27; CI: -0.55-0.01; P =.06). Terlipressin significantly decreased heart rate during the anhepatic phase (WMD: -6.58; 95% CI: -8.85 to -4.31; P <.00001) with a low heterogeneity (I2 = 41%) and significantly decreased heart rate during the neohepatic phase (WMD: -9.82; 95% CI: -11.96 to -7.68; P <.00001), although the heterogeneity was high (I2 > 50%). Conclusions An intravenous infusion of terlipressin perioperatively for LDLT has no effect on the creatinine values postoperatively. Larger randomized controlled trials on terlipressin infusions during liver transplantation are needed.
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U2 - 10.1016/j.transproceed.2015.06.023
DO - 10.1016/j.transproceed.2015.06.023
M3 - Review article
VL - 47
SP - 1917
EP - 1925
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 6
ER -