Effect of Perioperative Terlipressin on Postoperative Renal Function in Patients Who Have Undergone Living Donor Liver Transplantation

A Meta-Analysis of Randomized Controlled Trials

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4 Citations (Scopus)

Abstract

Background Recent studies have shown the efficacy of terlipressin on postoperative renal function in patients who have undergone living donor liver transplantation (LDLT). Objectives To evaluate the effect of perioperative terlipressin on postoperative renal function in patients who have undergone LDLT and to analyze the hemodynamic data during transplantation surgery. Study Design A meta-analysis. Methods We assessed the postoperative peak serum creatinine level and changes in the hemodynamic data (e.g. The mean arterial pressure, heart rate, and systemic vascular resistance). We collected randomized controlled trials from PubMed, EMBASE Drugs and Pharmacology, Cochrane Controlled Trials Register, and Cochrane Database on Systematic Reviews. Analysis was conducted using RevMan 5.2. Data from each trial were pooled and weighted by their mean differences and corresponding 95% confidence intervals (CI). A heterogeneity assessment was performed. Results Three trials (151 patients) were included. The difference in the mean (95% CI) peak serum creatinine (mg/dL) levels postoperatively was not significant between the intervention and control groups (weighted mean difference [WMD]: -0.27; CI: -0.55-0.01; P =.06). Terlipressin significantly decreased heart rate during the anhepatic phase (WMD: -6.58; 95% CI: -8.85 to -4.31; P <.00001) with a low heterogeneity (I2 = 41%) and significantly decreased heart rate during the neohepatic phase (WMD: -9.82; 95% CI: -11.96 to -7.68; P <.00001), although the heterogeneity was high (I2 > 50%). Conclusions An intravenous infusion of terlipressin perioperatively for LDLT has no effect on the creatinine values postoperatively. Larger randomized controlled trials on terlipressin infusions during liver transplantation are needed.

Original languageEnglish
Pages (from-to)1917-1925
Number of pages9
JournalTransplantation Proceedings
Volume47
Issue number6
DOIs
Publication statusPublished - 2015 Jan 1

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Living Donors
Liver Transplantation
Meta-Analysis
Randomized Controlled Trials
Kidney
Confidence Intervals
Creatinine
Heart Rate
Hemodynamics
Serum
PubMed
Intravenous Infusions
Vascular Resistance
Arterial Pressure
Transplantation
terlipressin
Databases
Pharmacology
Control Groups
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

@article{7fd09c0239654633a8fa55ac9e422234,
title = "Effect of Perioperative Terlipressin on Postoperative Renal Function in Patients Who Have Undergone Living Donor Liver Transplantation: A Meta-Analysis of Randomized Controlled Trials",
abstract = "Background Recent studies have shown the efficacy of terlipressin on postoperative renal function in patients who have undergone living donor liver transplantation (LDLT). Objectives To evaluate the effect of perioperative terlipressin on postoperative renal function in patients who have undergone LDLT and to analyze the hemodynamic data during transplantation surgery. Study Design A meta-analysis. Methods We assessed the postoperative peak serum creatinine level and changes in the hemodynamic data (e.g. The mean arterial pressure, heart rate, and systemic vascular resistance). We collected randomized controlled trials from PubMed, EMBASE Drugs and Pharmacology, Cochrane Controlled Trials Register, and Cochrane Database on Systematic Reviews. Analysis was conducted using RevMan 5.2. Data from each trial were pooled and weighted by their mean differences and corresponding 95{\%} confidence intervals (CI). A heterogeneity assessment was performed. Results Three trials (151 patients) were included. The difference in the mean (95{\%} CI) peak serum creatinine (mg/dL) levels postoperatively was not significant between the intervention and control groups (weighted mean difference [WMD]: -0.27; CI: -0.55-0.01; P =.06). Terlipressin significantly decreased heart rate during the anhepatic phase (WMD: -6.58; 95{\%} CI: -8.85 to -4.31; P <.00001) with a low heterogeneity (I2 = 41{\%}) and significantly decreased heart rate during the neohepatic phase (WMD: -9.82; 95{\%} CI: -11.96 to -7.68; P <.00001), although the heterogeneity was high (I2 > 50{\%}). Conclusions An intravenous infusion of terlipressin perioperatively for LDLT has no effect on the creatinine values postoperatively. Larger randomized controlled trials on terlipressin infusions during liver transplantation are needed.",
author = "won, {young ju} and Kim, {H. J.} and Lim, {Byung Gun} and Ahn, {Hyeong Sik} and Hwang, {M. H.} and Lee, {Il Ok}",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.transproceed.2015.06.023",
language = "English",
volume = "47",
pages = "1917--1925",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "6",

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TY - JOUR

T1 - Effect of Perioperative Terlipressin on Postoperative Renal Function in Patients Who Have Undergone Living Donor Liver Transplantation

T2 - A Meta-Analysis of Randomized Controlled Trials

AU - won, young ju

AU - Kim, H. J.

AU - Lim, Byung Gun

AU - Ahn, Hyeong Sik

AU - Hwang, M. H.

AU - Lee, Il Ok

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background Recent studies have shown the efficacy of terlipressin on postoperative renal function in patients who have undergone living donor liver transplantation (LDLT). Objectives To evaluate the effect of perioperative terlipressin on postoperative renal function in patients who have undergone LDLT and to analyze the hemodynamic data during transplantation surgery. Study Design A meta-analysis. Methods We assessed the postoperative peak serum creatinine level and changes in the hemodynamic data (e.g. The mean arterial pressure, heart rate, and systemic vascular resistance). We collected randomized controlled trials from PubMed, EMBASE Drugs and Pharmacology, Cochrane Controlled Trials Register, and Cochrane Database on Systematic Reviews. Analysis was conducted using RevMan 5.2. Data from each trial were pooled and weighted by their mean differences and corresponding 95% confidence intervals (CI). A heterogeneity assessment was performed. Results Three trials (151 patients) were included. The difference in the mean (95% CI) peak serum creatinine (mg/dL) levels postoperatively was not significant between the intervention and control groups (weighted mean difference [WMD]: -0.27; CI: -0.55-0.01; P =.06). Terlipressin significantly decreased heart rate during the anhepatic phase (WMD: -6.58; 95% CI: -8.85 to -4.31; P <.00001) with a low heterogeneity (I2 = 41%) and significantly decreased heart rate during the neohepatic phase (WMD: -9.82; 95% CI: -11.96 to -7.68; P <.00001), although the heterogeneity was high (I2 > 50%). Conclusions An intravenous infusion of terlipressin perioperatively for LDLT has no effect on the creatinine values postoperatively. Larger randomized controlled trials on terlipressin infusions during liver transplantation are needed.

AB - Background Recent studies have shown the efficacy of terlipressin on postoperative renal function in patients who have undergone living donor liver transplantation (LDLT). Objectives To evaluate the effect of perioperative terlipressin on postoperative renal function in patients who have undergone LDLT and to analyze the hemodynamic data during transplantation surgery. Study Design A meta-analysis. Methods We assessed the postoperative peak serum creatinine level and changes in the hemodynamic data (e.g. The mean arterial pressure, heart rate, and systemic vascular resistance). We collected randomized controlled trials from PubMed, EMBASE Drugs and Pharmacology, Cochrane Controlled Trials Register, and Cochrane Database on Systematic Reviews. Analysis was conducted using RevMan 5.2. Data from each trial were pooled and weighted by their mean differences and corresponding 95% confidence intervals (CI). A heterogeneity assessment was performed. Results Three trials (151 patients) were included. The difference in the mean (95% CI) peak serum creatinine (mg/dL) levels postoperatively was not significant between the intervention and control groups (weighted mean difference [WMD]: -0.27; CI: -0.55-0.01; P =.06). Terlipressin significantly decreased heart rate during the anhepatic phase (WMD: -6.58; 95% CI: -8.85 to -4.31; P <.00001) with a low heterogeneity (I2 = 41%) and significantly decreased heart rate during the neohepatic phase (WMD: -9.82; 95% CI: -11.96 to -7.68; P <.00001), although the heterogeneity was high (I2 > 50%). Conclusions An intravenous infusion of terlipressin perioperatively for LDLT has no effect on the creatinine values postoperatively. Larger randomized controlled trials on terlipressin infusions during liver transplantation are needed.

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U2 - 10.1016/j.transproceed.2015.06.023

DO - 10.1016/j.transproceed.2015.06.023

M3 - Review article

VL - 47

SP - 1917

EP - 1925

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 6

ER -