Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study

Yang Ki Minn, Seong Hye Choi, Young Ju Suh, Jee Hyang Jeong, Eun Joo Kim, Jong Hun Kim, Kyung Won Park, Moon Ho Park, Young Chul Youn, Bora Yoon, Seok Jin Choi, Youn Kyung Oh, Soo Jin Yoon

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)


    BACKGROUND: There is a lack of research on the effects of physical activity (PA) on the progression of Alzheimer's disease (AD).

    OBJECTIVES: We investigated whether PA is associated with progression of dementia and mortality in AD.

    METHODS: In the present study, 934 patients with mild-to-moderate AD were included. PA was evaluated using a questionnaire written by the caregiver. The outcome measures were the Clinical Dementia Rating-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living (S-IADL), Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), a global composite score of neuropsychological subtests, and mortality. They were evaluated annually and received a maximum of three follow-up examinations.

    RESULTS: Between-group differences compared with the no PA group in the change of CDR-SB scores were -0.431 (95% CI = -0.824∼-0.039; p = 0.031) for the moderate PA group (150-750 minutes per week of moderate intensity PA), and -1.148 (-1.656∼-0.639; p < 0.001) for the high PA group (>750 minutes per week). As PA increased, there was a significant trend to slow the rate of increase in the CDR-SB, S-IADL, and CGA-NPI scores. The patients with ≥150 minutes per week for each of non-recreational and recreational PAs had a lower risk of mortality compared to those with <150 minutes per week for each of the PAs (hazard ratio 0.22, 95% CI = 0.05∼0.88; p = 0.033).

    CONCLUSION: More PA is associated with slower progression of dementia severity, functional decline, and abnormal behavior, and with a lower risk of mortality in AD.

    Original languageEnglish
    Pages (from-to)249-261
    Number of pages13
    JournalJournal of Alzheimer's disease : JAD
    Issue number1
    Publication statusPublished - 2018 Jan 1


    • Alzheimer’s disease
    • dementia
    • mortality
    • physical activity
    • progression

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Clinical Psychology
    • Geriatrics and Gerontology
    • Psychiatry and Mental health


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