Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study

Yang Ki Minn, Seong Hye Choi, Young Ju Suh, Jee Hyang Jeong, Eun Joo Kim, Jong Hun Kim, Kyung Won Park, Moon Ho Park, Young Chul Youn, Bora Yoon, Seok Jin Choi, Youn Kyung Oh, Soo Jin Yoon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND: There is a lack of research on the effects of physical activity (PA) on the progression of Alzheimer's disease (AD).

OBJECTIVES: We investigated whether PA is associated with progression of dementia and mortality in AD.

METHODS: In the present study, 934 patients with mild-to-moderate AD were included. PA was evaluated using a questionnaire written by the caregiver. The outcome measures were the Clinical Dementia Rating-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living (S-IADL), Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), a global composite score of neuropsychological subtests, and mortality. They were evaluated annually and received a maximum of three follow-up examinations.

RESULTS: Between-group differences compared with the no PA group in the change of CDR-SB scores were -0.431 (95% CI = -0.824∼-0.039; p = 0.031) for the moderate PA group (150-750 minutes per week of moderate intensity PA), and -1.148 (-1.656∼-0.639; p < 0.001) for the high PA group (>750 minutes per week). As PA increased, there was a significant trend to slow the rate of increase in the CDR-SB, S-IADL, and CGA-NPI scores. The patients with ≥150 minutes per week for each of non-recreational and recreational PAs had a lower risk of mortality compared to those with <150 minutes per week for each of the PAs (hazard ratio 0.22, 95% CI = 0.05∼0.88; p = 0.033).

CONCLUSION: More PA is associated with slower progression of dementia severity, functional decline, and abnormal behavior, and with a lower risk of mortality in AD.

Original languageEnglish
Pages (from-to)249-261
Number of pages13
JournalJournal of Alzheimer's disease : JAD
Volume66
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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Republic of Korea
Dementia
Alzheimer Disease
Exercise
Research
Caregivers
Mortality
Activities of Daily Living
Equipment and Supplies
Outcome Assessment (Health Care)

Keywords

  • Alzheimer’s disease
  • dementia
  • mortality
  • physical activity
  • progression

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Effect of Physical Activity on the Progression of Alzheimer's Disease : The Clinical Research Center for Dementia of South Korea Study. / Minn, Yang Ki; Choi, Seong Hye; Suh, Young Ju; Jeong, Jee Hyang; Kim, Eun Joo; Kim, Jong Hun; Park, Kyung Won; Park, Moon Ho; Youn, Young Chul; Yoon, Bora; Choi, Seok Jin; Oh, Youn Kyung; Yoon, Soo Jin.

In: Journal of Alzheimer's disease : JAD, Vol. 66, No. 1, 01.01.2018, p. 249-261.

Research output: Contribution to journalArticle

Minn, YK, Choi, SH, Suh, YJ, Jeong, JH, Kim, EJ, Kim, JH, Park, KW, Park, MH, Youn, YC, Yoon, B, Choi, SJ, Oh, YK & Yoon, SJ 2018, 'Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study', Journal of Alzheimer's disease : JAD, vol. 66, no. 1, pp. 249-261. https://doi.org/10.3233/JAD-180333
Minn, Yang Ki ; Choi, Seong Hye ; Suh, Young Ju ; Jeong, Jee Hyang ; Kim, Eun Joo ; Kim, Jong Hun ; Park, Kyung Won ; Park, Moon Ho ; Youn, Young Chul ; Yoon, Bora ; Choi, Seok Jin ; Oh, Youn Kyung ; Yoon, Soo Jin. / Effect of Physical Activity on the Progression of Alzheimer's Disease : The Clinical Research Center for Dementia of South Korea Study. In: Journal of Alzheimer's disease : JAD. 2018 ; Vol. 66, No. 1. pp. 249-261.
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abstract = "BACKGROUND: There is a lack of research on the effects of physical activity (PA) on the progression of Alzheimer's disease (AD).OBJECTIVES: We investigated whether PA is associated with progression of dementia and mortality in AD.METHODS: In the present study, 934 patients with mild-to-moderate AD were included. PA was evaluated using a questionnaire written by the caregiver. The outcome measures were the Clinical Dementia Rating-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living (S-IADL), Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), a global composite score of neuropsychological subtests, and mortality. They were evaluated annually and received a maximum of three follow-up examinations.RESULTS: Between-group differences compared with the no PA group in the change of CDR-SB scores were -0.431 (95{\%} CI = -0.824∼-0.039; p = 0.031) for the moderate PA group (150-750 minutes per week of moderate intensity PA), and -1.148 (-1.656∼-0.639; p < 0.001) for the high PA group (>750 minutes per week). As PA increased, there was a significant trend to slow the rate of increase in the CDR-SB, S-IADL, and CGA-NPI scores. The patients with ≥150 minutes per week for each of non-recreational and recreational PAs had a lower risk of mortality compared to those with <150 minutes per week for each of the PAs (hazard ratio 0.22, 95{\%} CI = 0.05∼0.88; p = 0.033).CONCLUSION: More PA is associated with slower progression of dementia severity, functional decline, and abnormal behavior, and with a lower risk of mortality in AD.",
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AU - Choi, Seong Hye

AU - Suh, Young Ju

AU - Jeong, Jee Hyang

AU - Kim, Eun Joo

AU - Kim, Jong Hun

AU - Park, Kyung Won

AU - Park, Moon Ho

AU - Youn, Young Chul

AU - Yoon, Bora

AU - Choi, Seok Jin

AU - Oh, Youn Kyung

AU - Yoon, Soo Jin

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N2 - BACKGROUND: There is a lack of research on the effects of physical activity (PA) on the progression of Alzheimer's disease (AD).OBJECTIVES: We investigated whether PA is associated with progression of dementia and mortality in AD.METHODS: In the present study, 934 patients with mild-to-moderate AD were included. PA was evaluated using a questionnaire written by the caregiver. The outcome measures were the Clinical Dementia Rating-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living (S-IADL), Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), a global composite score of neuropsychological subtests, and mortality. They were evaluated annually and received a maximum of three follow-up examinations.RESULTS: Between-group differences compared with the no PA group in the change of CDR-SB scores were -0.431 (95% CI = -0.824∼-0.039; p = 0.031) for the moderate PA group (150-750 minutes per week of moderate intensity PA), and -1.148 (-1.656∼-0.639; p < 0.001) for the high PA group (>750 minutes per week). As PA increased, there was a significant trend to slow the rate of increase in the CDR-SB, S-IADL, and CGA-NPI scores. The patients with ≥150 minutes per week for each of non-recreational and recreational PAs had a lower risk of mortality compared to those with <150 minutes per week for each of the PAs (hazard ratio 0.22, 95% CI = 0.05∼0.88; p = 0.033).CONCLUSION: More PA is associated with slower progression of dementia severity, functional decline, and abnormal behavior, and with a lower risk of mortality in AD.

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KW - dementia

KW - mortality

KW - physical activity

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