Effect of pitavastatin treatment on ApoB-48 and Lp-PLA2 in patients with metabolic syndrome: Substudy of prospective comparative clinical study evaluating the efficacy and safety of pitavastatin in patients with metabolic syndrome

PROPIT Study Team

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Background: Apolipoprotein (Apo) B-48 is an intestinally derived lipoprotein that is expected to be a marker for cardiovascular disease (CVD). Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a vascular-specific inflammatory marker and important risk predictor of CVD. The aim of this study was to explore the effect of pitavastatin treatment and life style modification (LSM) on ApoB-48 and Lp-PLA2 levels in metabolic syndrome (MS) patients at relatively low risk for CVD, as a sub-analysis of a previous multi-center prospective study. Methods: We enrolled 75 patients with MS from the PROPIT study and randomized them into two treatment groups: 2 mg pitavastatin daily+intensive LSM or intensive LSM only. We measured the change of lipid profiles, ApoB-48 and Lp-PLA2 for 48 weeks. Results: Total cholesterol, low density lipoprotein cholesterol, non-high density lipoprotein cholesterol, and ApoB-100/A1 ratio were significantly improved in the pitavastatin+LSM group compared to the LSM only group (P ≤ 0.001). Pitavastatin+LSM did not change the level of ApoB-48 in subjects overall, but the level of ApoB-48 was significantly lower in the higher mean baseline value group of ApoB-48. The change in Lp-PLA2 was not significant after intervention in either group after treatment with pitavastatin for 1 year. Conclusion: Pitavastatin treatment and LSM significantly improved lipid profiles, ApoB-100/A1 ratio, and reduced ApoB-48 levels in the higher mean baseline value group of ApoB-48, but did not significantly alter the Lp-PLA2 levels.

    Original languageEnglish
    Pages (from-to)120-126
    Number of pages7
    JournalEndocrinology and Metabolism
    Volume31
    Issue number1
    DOIs
    Publication statusPublished - 2016 Mar 1

    Keywords

    • Apolipoprotein B-48
    • Lp-PLA
    • Metabolic syndrome
    • Pitavastatin

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

    Fingerprint

    Dive into the research topics of 'Effect of pitavastatin treatment on ApoB-48 and Lp-PLA<sub>2</sub> in patients with metabolic syndrome: Substudy of prospective comparative clinical study evaluating the efficacy and safety of pitavastatin in patients with metabolic syndrome'. Together they form a unique fingerprint.

    Cite this