Effect of pitavastatin treatment on changes of plaque volume and composition according to the reduction of high-sensitivity C-reactive protein levels

Young Joon Hong, Myung Ho Jeong, Youngkeun Ahn, Sang Wook Kim, Jang Ho Bae, Seung Ho Hur, Tae Hoon Ahn, Seung-Woon Rha, Kee Sik Kim, In Ho Chae, Jong Hyun Kim, Kyeong Ho Yun, Seok Kyu Oh

Research output: Contribution to journalArticle

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Abstract

Background: There are few data regarding the effect of statins on regression and compositional changes of plaque according to the reduction in high-sensitivity C-reactive protein (hs-CRP) levels in acute myocardial infarction (AMI) patients. Methods: We used serial virtual histology-intravascular ultrasound to assess the efficacy of pitavastatin (dosage: 2. mg/day) on plaque regression and compositional changes according to the degree of reduction in hs-CRP levels from baseline to follow-up [≥1. mg/dl (n= 62) vs. <1. mg/dl (n= 32)] in non-intervened non-infarct related artery in AMI patients who were enrolled in the Livalo in acute myocardial infarction study (LAMIS). Results: Total atheroma and percent atheroma volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-1.7±12.4mm3 vs. +2.7±7.8mm3, p<0.015, and -0.4±3.4% vs. +0.4±4.8%, p<0.001, respectively). Absolute and %necrotic core volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-0.4±3.5mm3 vs. +1.9±3.4mm3, p=0.038, and -1.1±4.9% vs. +2.7±4.7%, p=0.016, respectively). Reduction in hs-CRP ≥1mg/dl at follow-up was the independent predictor of reduction of percent atheroma volume and %necrotic core volume at follow-up [odds ratio (OR), 2.228; 95% confidence interval (CI), 1.390-2.977, p=0.016, and OR, 2.204; 95% CI, 1.512-2.916, p=0.020, respectively]. Conclusions: Reduction in hs-CRP levels in AMI patients plays an important role in the beneficial effects of statins on the regression and compositional change of coronary plaque.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalJournal of Cardiology
Volume60
Issue number4
DOIs
Publication statusPublished - 2012 Oct 1

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C-Reactive Protein
Atherosclerotic Plaques
Myocardial Infarction
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Therapeutics
Odds Ratio
Confidence Intervals
pitavastatin
Histology
Arteries

Keywords

  • Acute myocardial infarction
  • Inflammation
  • Intravascular ultrasound
  • Plaque
  • Statin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of pitavastatin treatment on changes of plaque volume and composition according to the reduction of high-sensitivity C-reactive protein levels. / Hong, Young Joon; Jeong, Myung Ho; Ahn, Youngkeun; Kim, Sang Wook; Bae, Jang Ho; Hur, Seung Ho; Ahn, Tae Hoon; Rha, Seung-Woon; Kim, Kee Sik; Chae, In Ho; Kim, Jong Hyun; Yun, Kyeong Ho; Oh, Seok Kyu.

In: Journal of Cardiology, Vol. 60, No. 4, 01.10.2012, p. 277-282.

Research output: Contribution to journalArticle

Hong, YJ, Jeong, MH, Ahn, Y, Kim, SW, Bae, JH, Hur, SH, Ahn, TH, Rha, S-W, Kim, KS, Chae, IH, Kim, JH, Yun, KH & Oh, SK 2012, 'Effect of pitavastatin treatment on changes of plaque volume and composition according to the reduction of high-sensitivity C-reactive protein levels', Journal of Cardiology, vol. 60, no. 4, pp. 277-282. https://doi.org/10.1016/j.jjcc.2012.04.003
Hong, Young Joon ; Jeong, Myung Ho ; Ahn, Youngkeun ; Kim, Sang Wook ; Bae, Jang Ho ; Hur, Seung Ho ; Ahn, Tae Hoon ; Rha, Seung-Woon ; Kim, Kee Sik ; Chae, In Ho ; Kim, Jong Hyun ; Yun, Kyeong Ho ; Oh, Seok Kyu. / Effect of pitavastatin treatment on changes of plaque volume and composition according to the reduction of high-sensitivity C-reactive protein levels. In: Journal of Cardiology. 2012 ; Vol. 60, No. 4. pp. 277-282.
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abstract = "Background: There are few data regarding the effect of statins on regression and compositional changes of plaque according to the reduction in high-sensitivity C-reactive protein (hs-CRP) levels in acute myocardial infarction (AMI) patients. Methods: We used serial virtual histology-intravascular ultrasound to assess the efficacy of pitavastatin (dosage: 2. mg/day) on plaque regression and compositional changes according to the degree of reduction in hs-CRP levels from baseline to follow-up [≥1. mg/dl (n= 62) vs. <1. mg/dl (n= 32)] in non-intervened non-infarct related artery in AMI patients who were enrolled in the Livalo in acute myocardial infarction study (LAMIS). Results: Total atheroma and percent atheroma volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-1.7±12.4mm3 vs. +2.7±7.8mm3, p<0.015, and -0.4±3.4{\%} vs. +0.4±4.8{\%}, p<0.001, respectively). Absolute and {\%}necrotic core volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-0.4±3.5mm3 vs. +1.9±3.4mm3, p=0.038, and -1.1±4.9{\%} vs. +2.7±4.7{\%}, p=0.016, respectively). Reduction in hs-CRP ≥1mg/dl at follow-up was the independent predictor of reduction of percent atheroma volume and {\%}necrotic core volume at follow-up [odds ratio (OR), 2.228; 95{\%} confidence interval (CI), 1.390-2.977, p=0.016, and OR, 2.204; 95{\%} CI, 1.512-2.916, p=0.020, respectively]. Conclusions: Reduction in hs-CRP levels in AMI patients plays an important role in the beneficial effects of statins on the regression and compositional change of coronary plaque.",
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author = "Hong, {Young Joon} and Jeong, {Myung Ho} and Youngkeun Ahn and Kim, {Sang Wook} and Bae, {Jang Ho} and Hur, {Seung Ho} and Ahn, {Tae Hoon} and Seung-Woon Rha and Kim, {Kee Sik} and Chae, {In Ho} and Kim, {Jong Hyun} and Yun, {Kyeong Ho} and Oh, {Seok Kyu}",
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T1 - Effect of pitavastatin treatment on changes of plaque volume and composition according to the reduction of high-sensitivity C-reactive protein levels

AU - Hong, Young Joon

AU - Jeong, Myung Ho

AU - Ahn, Youngkeun

AU - Kim, Sang Wook

AU - Bae, Jang Ho

AU - Hur, Seung Ho

AU - Ahn, Tae Hoon

AU - Rha, Seung-Woon

AU - Kim, Kee Sik

AU - Chae, In Ho

AU - Kim, Jong Hyun

AU - Yun, Kyeong Ho

AU - Oh, Seok Kyu

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Background: There are few data regarding the effect of statins on regression and compositional changes of plaque according to the reduction in high-sensitivity C-reactive protein (hs-CRP) levels in acute myocardial infarction (AMI) patients. Methods: We used serial virtual histology-intravascular ultrasound to assess the efficacy of pitavastatin (dosage: 2. mg/day) on plaque regression and compositional changes according to the degree of reduction in hs-CRP levels from baseline to follow-up [≥1. mg/dl (n= 62) vs. <1. mg/dl (n= 32)] in non-intervened non-infarct related artery in AMI patients who were enrolled in the Livalo in acute myocardial infarction study (LAMIS). Results: Total atheroma and percent atheroma volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-1.7±12.4mm3 vs. +2.7±7.8mm3, p<0.015, and -0.4±3.4% vs. +0.4±4.8%, p<0.001, respectively). Absolute and %necrotic core volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-0.4±3.5mm3 vs. +1.9±3.4mm3, p=0.038, and -1.1±4.9% vs. +2.7±4.7%, p=0.016, respectively). Reduction in hs-CRP ≥1mg/dl at follow-up was the independent predictor of reduction of percent atheroma volume and %necrotic core volume at follow-up [odds ratio (OR), 2.228; 95% confidence interval (CI), 1.390-2.977, p=0.016, and OR, 2.204; 95% CI, 1.512-2.916, p=0.020, respectively]. Conclusions: Reduction in hs-CRP levels in AMI patients plays an important role in the beneficial effects of statins on the regression and compositional change of coronary plaque.

AB - Background: There are few data regarding the effect of statins on regression and compositional changes of plaque according to the reduction in high-sensitivity C-reactive protein (hs-CRP) levels in acute myocardial infarction (AMI) patients. Methods: We used serial virtual histology-intravascular ultrasound to assess the efficacy of pitavastatin (dosage: 2. mg/day) on plaque regression and compositional changes according to the degree of reduction in hs-CRP levels from baseline to follow-up [≥1. mg/dl (n= 62) vs. <1. mg/dl (n= 32)] in non-intervened non-infarct related artery in AMI patients who were enrolled in the Livalo in acute myocardial infarction study (LAMIS). Results: Total atheroma and percent atheroma volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-1.7±12.4mm3 vs. +2.7±7.8mm3, p<0.015, and -0.4±3.4% vs. +0.4±4.8%, p<0.001, respectively). Absolute and %necrotic core volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-0.4±3.5mm3 vs. +1.9±3.4mm3, p=0.038, and -1.1±4.9% vs. +2.7±4.7%, p=0.016, respectively). Reduction in hs-CRP ≥1mg/dl at follow-up was the independent predictor of reduction of percent atheroma volume and %necrotic core volume at follow-up [odds ratio (OR), 2.228; 95% confidence interval (CI), 1.390-2.977, p=0.016, and OR, 2.204; 95% CI, 1.512-2.916, p=0.020, respectively]. Conclusions: Reduction in hs-CRP levels in AMI patients plays an important role in the beneficial effects of statins on the regression and compositional change of coronary plaque.

KW - Acute myocardial infarction

KW - Inflammation

KW - Intravascular ultrasound

KW - Plaque

KW - Statin

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