Effect of pitavastatin treatment on changes of plaque volume and composition according to the reduction of high-sensitivity C-reactive protein levels

Young Joon Hong, Myung Ho Jeong, Youngkeun Ahn, Sang Wook Kim, Jang Ho Bae, Seung Ho Hur, Tae Hoon Ahn, Seung-Woon Rha, Kee Sik Kim, In Ho Chae, Jong Hyun Kim, Kyeong Ho Yun, Seok Kyu Oh

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Abstract

Background: There are few data regarding the effect of statins on regression and compositional changes of plaque according to the reduction in high-sensitivity C-reactive protein (hs-CRP) levels in acute myocardial infarction (AMI) patients. Methods: We used serial virtual histology-intravascular ultrasound to assess the efficacy of pitavastatin (dosage: 2. mg/day) on plaque regression and compositional changes according to the degree of reduction in hs-CRP levels from baseline to follow-up [≥1. mg/dl (n= 62) vs. <1. mg/dl (n= 32)] in non-intervened non-infarct related artery in AMI patients who were enrolled in the Livalo in acute myocardial infarction study (LAMIS). Results: Total atheroma and percent atheroma volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-1.7±12.4mm3 vs. +2.7±7.8mm3, p<0.015, and -0.4±3.4% vs. +0.4±4.8%, p<0.001, respectively). Absolute and %necrotic core volumes decreased more significantly in patients with reduction in hs-CRP ≥1mg/dl compared with those with reduction in hs-CRP <1mg/dl (-0.4±3.5mm3 vs. +1.9±3.4mm3, p=0.038, and -1.1±4.9% vs. +2.7±4.7%, p=0.016, respectively). Reduction in hs-CRP ≥1mg/dl at follow-up was the independent predictor of reduction of percent atheroma volume and %necrotic core volume at follow-up [odds ratio (OR), 2.228; 95% confidence interval (CI), 1.390-2.977, p=0.016, and OR, 2.204; 95% CI, 1.512-2.916, p=0.020, respectively]. Conclusions: Reduction in hs-CRP levels in AMI patients plays an important role in the beneficial effects of statins on the regression and compositional change of coronary plaque.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalJournal of Cardiology
Volume60
Issue number4
DOIs
Publication statusPublished - 2012 Oct 1

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Keywords

  • Acute myocardial infarction
  • Inflammation
  • Intravascular ultrasound
  • Plaque
  • Statin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hong, Y. J., Jeong, M. H., Ahn, Y., Kim, S. W., Bae, J. H., Hur, S. H., Ahn, T. H., Rha, S-W., Kim, K. S., Chae, I. H., Kim, J. H., Yun, K. H., & Oh, S. K. (2012). Effect of pitavastatin treatment on changes of plaque volume and composition according to the reduction of high-sensitivity C-reactive protein levels. Journal of Cardiology, 60(4), 277-282. https://doi.org/10.1016/j.jjcc.2012.04.003