Effect of repeated seizure experiences on tyrosine hydroxylase immunoreactivities in the brain of genetically epilepsy-prone rats

Jae Ryun Ryu, Chan Young Shin, Kyu Hwan Park, Gye Sun Jeon, Hyoung Chun Kim, Won-Ki Kim, John W. Dailey, Phillip C. Jobe, Sa Sun Cho, Kwang Ho Ko

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12 Citations (Scopus)

Abstract

The genetically epilepsy-prone rat (GEPR) is a model of generalized tonic/clonic epilepsy, and has functional noradrenergic deficiencies that act as partial determinants for the seizure predisposition and expression. The present study investigated the effect of repeated seizure experiences by acoustic stimulation (110 dB, 10 times) on the immunoreactivities of tyrosine hydroxylase (TH), a rate-determining enzyme in the synthesis of norepinephrine, in brain regions of GEPRs. TH immunoreactivity in locus coeruleus, the major noradrenergic nucleus in brain, was lower in GEPRs than control Sprague-Dawley rats. It was also decreased in several regions including inferior colliculus of GEPRs. Repeated experiences of audiogenic seizures further decreased TH immunoreactivities in locus coeruleus and inferior colliculus of GEPRs. The results from the present study suggest that the lower immunoreactivities of TH in locus coeruleus and inferior colliculus contribute, at least in part, to the noradrenergic deficits in GEPRs, and repeated seizure experiences further intensified these noradrenergic deficits, which may be related to the altered seizure expression by repetitive audiogenic seizure in GEPRs.

Original languageEnglish
Pages (from-to)777-782
Number of pages6
JournalBrain Research Bulletin
Volume53
Issue number6
DOIs
Publication statusPublished - 2000 Dec 1
Externally publishedYes

Keywords

  • Genetically epilepsy-prone rat
  • Immunoreactivity
  • Inferior colliculus
  • Locus coeruleus
  • Repeated audiogenic seizures
  • Tyrosine hydroxyalse

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Ryu, J. R., Shin, C. Y., Park, K. H., Jeon, G. S., Kim, H. C., Kim, W-K., Dailey, J. W., Jobe, P. C., Cho, S. S., & Ko, K. H. (2000). Effect of repeated seizure experiences on tyrosine hydroxylase immunoreactivities in the brain of genetically epilepsy-prone rats. Brain Research Bulletin, 53(6), 777-782. https://doi.org/10.1016/S0361-9230(00)00373-7