Effect of rifampin on the pharmacokinetics and pharmacodynamics of gliclazide

Ji Young Park, Kyoung Ah Kim, Pil Whan Park, Chan Woong Park, Jae Gook Shin

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objective: Our objective was to investigate the effect of rifampin (INN, rifampicin) on the pharmacokinetics and pharmacodynamics of gliclazide, a sulfonylurea antidiabetic drug. Method: In a randomized 2-way crossover study with a 4-week washout period, 9 healthy Korean subjects were treated once daily for 6 days with 600 mg rifampin or with placebo. On day 7, a single dose of 80 mg gliclazide was administered orally. Plasma gliclazide, blood glucose, and insulin concentrations were measured. Results: Rifampin decreased the mean area under the plasma concentration-time curve for gliclazide by 70% (P < .001) and the mean elimination half-life from 9.5 to 3.3 hours (P < .05). The apparent oral clearance of gliclazide increased about 4-fold after rifampin treatment (P < .001). A significant difference in the blood glucose response to gliclazide was observed between the placebo and rifampin phases. Conclusion: The effect of rifampin on the pharmacokinetics and pharmacodynamics of gliclazide suggests that rifampin affects the disposition of gliclazide in humans, possibly by the induction of cytochrome P450 2C9. Concomitant use of rifampin with gliclazide can considerably reduce the glucose-lowering effects of gliclazide.

Original languageEnglish
Pages (from-to)334-340
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume74
Issue number4
DOIs
Publication statusPublished - 2003 Oct 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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