Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes

A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial

Jee Hyun An, Dong Lim Kim, Tae Bum Lee, Kyeong Jin Kim, Sun Hwa Kim, Nam Hoon Kim, Hee Young Kim, Dong Seop Choi, Sin Gon Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Rubus occidentalis (RO) has beneficial effects on glucose and lipid profiles in vitro. The aim of the study was to investigate RO extract effect on metabolic parameters in prediabetic patients, adopting a 12-week, randomized, double-blind, placebo-controlled trial. Forty-four patients (age 59.0 ± 8.2 years, 70.5% females, HbA1c 5.8 ± 0.4%) were divided into placebo (n = 13), low-dose RO extract (LRE; n = 14), or high-dose RO extract (HRE; n = 17) groups. Either 900 or 1800 mg per day of RO extract was administered orally. Area under the curve for glucose obtained 2 h after a 75-g oral glucose tolerance test was significantly decreased in the HRE group, compared with the placebo group (−28.1 ± 42.4 vs. +13.4 ± 52.6 mg/dL, p < 0.05). Homoeostasis model assessment-B was increased (+17.11 ± 10.69, +5.24 ± 4.10, and +0.86 ± 6.01 in HRE, LRE, and placebo, respectively, p < 0.05). Serum levels of monocyte chemoattractant protein-1 and oxidized low-density lipoprotein were significantly decreased by treatment in a dose-dependent manner (monocyte chemoattractant protein-1: −35.0 ± 21.2, +8.4 ± 18.1, and +24.2 ± 14.5; oxidized low-density lipoprotein: −19.7 ± 8.5, −13.1 ± 7.2, and −2.2 ± 11.0 in the HRE, LRE, and placebo, respectively, p < 0.05). The results support the beneficial effects of RO extract on the control of glycemia and vascular inflammation in prediabetic patients. (ClinicalTrials.gov: NCT01964703).

Original languageEnglish
Pages (from-to)1634-1640
Number of pages7
JournalPhytotherapy Research
Volume30
Issue number10
DOIs
Publication statusPublished - 2016 Oct 1

Fingerprint

Prediabetic State
Controlled Clinical Trials
Placebos
Chemokine CCL2
Glucose
Glucose Tolerance Test
Area Under Curve
Blood Vessels
Rubus
Homeostasis
Inflammation
Lipids
Serum

Keywords

  • atherosclerosis
  • black raspberry
  • metabolic syndrome
  • prediabetes
  • Rubus occidentalis

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes : A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial. / An, Jee Hyun; Kim, Dong Lim; Lee, Tae Bum; Kim, Kyeong Jin; Kim, Sun Hwa; Kim, Nam Hoon; Kim, Hee Young; Choi, Dong Seop; Kim, Sin Gon.

In: Phytotherapy Research, Vol. 30, No. 10, 01.10.2016, p. 1634-1640.

Research output: Contribution to journalArticle

An, Jee Hyun ; Kim, Dong Lim ; Lee, Tae Bum ; Kim, Kyeong Jin ; Kim, Sun Hwa ; Kim, Nam Hoon ; Kim, Hee Young ; Choi, Dong Seop ; Kim, Sin Gon. / Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes : A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial. In: Phytotherapy Research. 2016 ; Vol. 30, No. 10. pp. 1634-1640.
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abstract = "Rubus occidentalis (RO) has beneficial effects on glucose and lipid profiles in vitro. The aim of the study was to investigate RO extract effect on metabolic parameters in prediabetic patients, adopting a 12-week, randomized, double-blind, placebo-controlled trial. Forty-four patients (age 59.0 ± 8.2 years, 70.5{\%} females, HbA1c 5.8 ± 0.4{\%}) were divided into placebo (n = 13), low-dose RO extract (LRE; n = 14), or high-dose RO extract (HRE; n = 17) groups. Either 900 or 1800 mg per day of RO extract was administered orally. Area under the curve for glucose obtained 2 h after a 75-g oral glucose tolerance test was significantly decreased in the HRE group, compared with the placebo group (−28.1 ± 42.4 vs. +13.4 ± 52.6 mg/dL, p < 0.05). Homoeostasis model assessment-B was increased (+17.11 ± 10.69, +5.24 ± 4.10, and +0.86 ± 6.01 in HRE, LRE, and placebo, respectively, p < 0.05). Serum levels of monocyte chemoattractant protein-1 and oxidized low-density lipoprotein were significantly decreased by treatment in a dose-dependent manner (monocyte chemoattractant protein-1: −35.0 ± 21.2, +8.4 ± 18.1, and +24.2 ± 14.5; oxidized low-density lipoprotein: −19.7 ± 8.5, −13.1 ± 7.2, and −2.2 ± 11.0 in the HRE, LRE, and placebo, respectively, p < 0.05). The results support the beneficial effects of RO extract on the control of glycemia and vascular inflammation in prediabetic patients. (ClinicalTrials.gov: NCT01964703).",
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