Effect of scaffolds with bone growth factors on new bone formation

Hae Ryong Song, Swee Hin Teoh, Jun Ho Wang, Hak Jun Kim, Ji Hoon Bae, Sung Eun Kim, Jerry Chan, Zhi Yong Zhang, Chang Wug Oh

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bone tissue engineering (BTE) using scaffolds with growth factors/ stem cells has received some success in clinical trails. Recently, osteogenic scaffolds using absorbable or nonabsorbable biomaterials have being investigated to repair bone defects. Scaffolds can provide the osteoconduction effect as well as a media to trap cells and allow them to proliferate and differentiate. Bioreactors provide a means to uniformly coat the scaffolds with cells and allow cells to proliferate better. Here we describe our work on preclinical animal trials applying the above concept to regenerate bone.

Original languageEnglish
Title of host publicationHandbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine
PublisherPan Stanford Publishing Pte. Ltd.
Pages871-901
Number of pages31
ISBN (Print)9789814267854
DOIs
Publication statusPublished - 2012 Jan 31

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Song, H. R., Teoh, S. H., Wang, J. H., Kim, H. J., Bae, J. H., Kim, S. E., Chan, J., Zhang, Z. Y., & Oh, C. W. (2012). Effect of scaffolds with bone growth factors on new bone formation. In Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine (pp. 871-901). Pan Stanford Publishing Pte. Ltd.. https://doi.org/10.4032/9789814267861