Effect of sleep deprivation on the male reproductive system in rats

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

There has been no study reporting on the influence of sleep deprivation on the male reproductive system including sperm quality. In this study, we hypothesized that sleep deprivation could lead to adverse effect on the male reproductive system. The rats were divided into three groups: 1) control (home-cage, n = 10); 2) SD4 (sleep deprivation for 4 days, n = 10); and 3) SD7 (sleep deprivation for 7 days, n = 10). Sleep deprivation was performed by a modified multiple platform method. Sperm quality (sperm motion parameters and counts), hormone levels (corticosterone and testosterone), and the histopathology of testis were evaluated and compared between the three groups. A statistically significant reduction (P = 0.018) was observed in sperm motility in the SD7 group compared to those of the control group. However, there were no significant differences in other sperm motion parameters, or in sperm counts of the testis and cauda epididymis between three groups. Compared with the control group, the SD4 (P = 0.033) and SD7 (P = 0.002) groups exhibited significant increases of corticosterone levels, but significant decreases of testosterone levels were found in the SD4 (P = 0.001) and SD7 (P < 0.001) groups. Seminiferous tubular atrophy and/or spermatid retention was partially observed in the SD4 and SD7 groups, compared with the normal histopathology of the control group. Sleep deprivation may have an adverse effect on the male reproductive system in rats.

Original languageEnglish
Pages (from-to)1624-1630
Number of pages7
JournalJournal of Korean Medical Science
Volume31
Issue number10
DOIs
Publication statusPublished - 2016

Fingerprint

Sleep Deprivation
Spermatozoa
Control Groups
Corticosterone
Testosterone
Testis
Sperm Count
Spermatids
Sperm Motility
Epididymis
Atrophy
Hormones

Keywords

  • Corticosterone
  • Histopathology
  • Sleep deprivation
  • Sperm count
  • Sperm motility
  • Testosterone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of sleep deprivation on the male reproductive system in rats. / Choi, Ji Ho; Lee, Seung Hoon; Bae, Jae Hyun; Shim, Ji Sung; Park, Hong Seok; Kim, Young Sik; Shin, Chol.

In: Journal of Korean Medical Science, Vol. 31, No. 10, 2016, p. 1624-1630.

Research output: Contribution to journalArticle

@article{67c9959fb22a47eba1f2af7d060b34f3,
title = "Effect of sleep deprivation on the male reproductive system in rats",
abstract = "There has been no study reporting on the influence of sleep deprivation on the male reproductive system including sperm quality. In this study, we hypothesized that sleep deprivation could lead to adverse effect on the male reproductive system. The rats were divided into three groups: 1) control (home-cage, n = 10); 2) SD4 (sleep deprivation for 4 days, n = 10); and 3) SD7 (sleep deprivation for 7 days, n = 10). Sleep deprivation was performed by a modified multiple platform method. Sperm quality (sperm motion parameters and counts), hormone levels (corticosterone and testosterone), and the histopathology of testis were evaluated and compared between the three groups. A statistically significant reduction (P = 0.018) was observed in sperm motility in the SD7 group compared to those of the control group. However, there were no significant differences in other sperm motion parameters, or in sperm counts of the testis and cauda epididymis between three groups. Compared with the control group, the SD4 (P = 0.033) and SD7 (P = 0.002) groups exhibited significant increases of corticosterone levels, but significant decreases of testosterone levels were found in the SD4 (P = 0.001) and SD7 (P < 0.001) groups. Seminiferous tubular atrophy and/or spermatid retention was partially observed in the SD4 and SD7 groups, compared with the normal histopathology of the control group. Sleep deprivation may have an adverse effect on the male reproductive system in rats.",
keywords = "Corticosterone, Histopathology, Sleep deprivation, Sperm count, Sperm motility, Testosterone",
author = "Choi, {Ji Ho} and Lee, {Seung Hoon} and Bae, {Jae Hyun} and Shim, {Ji Sung} and Park, {Hong Seok} and Kim, {Young Sik} and Chol Shin",
year = "2016",
doi = "10.3346/jkms.2016.31.10.1624",
language = "English",
volume = "31",
pages = "1624--1630",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "10",

}

TY - JOUR

T1 - Effect of sleep deprivation on the male reproductive system in rats

AU - Choi, Ji Ho

AU - Lee, Seung Hoon

AU - Bae, Jae Hyun

AU - Shim, Ji Sung

AU - Park, Hong Seok

AU - Kim, Young Sik

AU - Shin, Chol

PY - 2016

Y1 - 2016

N2 - There has been no study reporting on the influence of sleep deprivation on the male reproductive system including sperm quality. In this study, we hypothesized that sleep deprivation could lead to adverse effect on the male reproductive system. The rats were divided into three groups: 1) control (home-cage, n = 10); 2) SD4 (sleep deprivation for 4 days, n = 10); and 3) SD7 (sleep deprivation for 7 days, n = 10). Sleep deprivation was performed by a modified multiple platform method. Sperm quality (sperm motion parameters and counts), hormone levels (corticosterone and testosterone), and the histopathology of testis were evaluated and compared between the three groups. A statistically significant reduction (P = 0.018) was observed in sperm motility in the SD7 group compared to those of the control group. However, there were no significant differences in other sperm motion parameters, or in sperm counts of the testis and cauda epididymis between three groups. Compared with the control group, the SD4 (P = 0.033) and SD7 (P = 0.002) groups exhibited significant increases of corticosterone levels, but significant decreases of testosterone levels were found in the SD4 (P = 0.001) and SD7 (P < 0.001) groups. Seminiferous tubular atrophy and/or spermatid retention was partially observed in the SD4 and SD7 groups, compared with the normal histopathology of the control group. Sleep deprivation may have an adverse effect on the male reproductive system in rats.

AB - There has been no study reporting on the influence of sleep deprivation on the male reproductive system including sperm quality. In this study, we hypothesized that sleep deprivation could lead to adverse effect on the male reproductive system. The rats were divided into three groups: 1) control (home-cage, n = 10); 2) SD4 (sleep deprivation for 4 days, n = 10); and 3) SD7 (sleep deprivation for 7 days, n = 10). Sleep deprivation was performed by a modified multiple platform method. Sperm quality (sperm motion parameters and counts), hormone levels (corticosterone and testosterone), and the histopathology of testis were evaluated and compared between the three groups. A statistically significant reduction (P = 0.018) was observed in sperm motility in the SD7 group compared to those of the control group. However, there were no significant differences in other sperm motion parameters, or in sperm counts of the testis and cauda epididymis between three groups. Compared with the control group, the SD4 (P = 0.033) and SD7 (P = 0.002) groups exhibited significant increases of corticosterone levels, but significant decreases of testosterone levels were found in the SD4 (P = 0.001) and SD7 (P < 0.001) groups. Seminiferous tubular atrophy and/or spermatid retention was partially observed in the SD4 and SD7 groups, compared with the normal histopathology of the control group. Sleep deprivation may have an adverse effect on the male reproductive system in rats.

KW - Corticosterone

KW - Histopathology

KW - Sleep deprivation

KW - Sperm count

KW - Sperm motility

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=84983609931&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983609931&partnerID=8YFLogxK

U2 - 10.3346/jkms.2016.31.10.1624

DO - 10.3346/jkms.2016.31.10.1624

M3 - Article

C2 - 27550492

AN - SCOPUS:84983609931

VL - 31

SP - 1624

EP - 1630

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 10

ER -