Effect of surface properties on the antithrombogenicity of silk fibroin/S-carboxymethyl kerateine blend films

K. Y. Lee, S. J. Kong, W. H. Park, W. S. Ha, Ick Chan Kwon

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63 Citations (Scopus)

Abstract

Polymeric blends of silk fibroin (SF) and S-carboxymethyl kerateine (SCMK) were prepared by the solvent casting method to study the effect of surface properties on the antithrombogenicity. The films of SF/SCMK showed better antithrombogenic properties than SF or SCMK alone. Among them, the film containing 50 wt% SCMK showed the best antithrombogenicity. When the SF/SCMK films were treated with methanol, the antithrombogenicity of the films was scarcely affected except the SF-rich ones. The enhanced antithrombogenic properties were explained in terms of polarity of the surface. The blend films showed an enhancement of polar contribution to surface free energy (γ(s)(P)) and polar stabilization energy (I(sw)). SF-rich films showed high γ(s)(P) and I(sw) values when treated with methanol. This change of surface properties was considered to be due to the fact that the conformational transition from random coil structure to β-structure of proteins may have affected the surface properties, especially the polar properties.

Original languageEnglish
Pages (from-to)905-914
Number of pages10
JournalJournal of Biomaterials Science, Polymer Edition
Volume9
Issue number9
Publication statusPublished - 1998 Sep 19
Externally publishedYes

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Keywords

  • β-structure of protein
  • Antithrombogenicity
  • Polar surface
  • S-carboxymethyl kerateine
  • Silk fibroin

ASJC Scopus subject areas

  • Biophysics

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