Effect of testosterone replacement treatment in testosterone deficiency syndrome patients with metabolic syndrome

Seung Min Jeong, Byeong Kuk Ham, Min Gu Park, Mi Mi Oh, Duck Ki Yoon, Je Jong Kim, Du Geon Moon

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Purpose: This study was conducted to investigate the effect of testosterone replacement treatment (TRT) in testosterone deficiency syndrome (TDS) patients with metabolic syndrome. Materials and Methods: We reviewed the data of 200 men who were diagnosed with TDS and were undergoing TRT between August 2006 and August 2009. The 200 patients were divided into two groups (group 1: 71 patients with metabolic syndrome, group 2: 129 patients without metabolic syndrome) depending on metabolic syndrome, which was diagnosed according to the NCEP III criteria for Asians. Age, BMI (body mass index), waist circumference, serologic tests, AMS (the Aging Males' Symptoms scale), and IIEF (International Index of Erectile Function) were measured. Results: In group 1, waist circumference and fasting glucose were significantly decreased; hemoglobin and total testosterone were increased; and the somatovegetative scale score of the AMS, the total AMS score, the erectile function score of the IIEF, the overall satisfaction score of the IIEF, and the total IIEF score were significantly improved after TRT. On the other hand, in group 2, waist circumference, BMI, total cholesterol, LDL, and fasting glucose were significantly decreased; hemoglobin and total testosterone were increased; and the 2 subscale scores of the AMS (psychologic and somatovegetative), the total AMS score, all subscale scores of the IIEF, and the total IIEF score were significantly improved after TRT. Conclusions: Overall, the patients who had TDS with metabolic syndrome showed less improvement in AMS, IIEF, and serum variables. Therefore, the correction of metabolic syndrome, such as diabetes, obesity, and hypertension, should be considered during TRT.

    Original languageEnglish
    Pages (from-to)566-571
    Number of pages6
    JournalKorean Journal of Urology
    Volume52
    Issue number8
    DOIs
    Publication statusPublished - 2011 Aug

    Keywords

    • Hormone replacement therapy
    • Metabolic syndrome X
    • Testosterone

    ASJC Scopus subject areas

    • Urology

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