Effect of the combination of CI-988 and morphine on neuropathic pain after spinal cord injury in rats

Junesun Kim, Youngkyung Kim, Suk Chan Hahm, Young Wook Yoon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cholecystokinin is known to be involved in the modulation of nociception and to reduce the efficacy of morphine analgesia. This study investigated the effects of intrathecal administration of morphine and the cholecystokinin type B antagonist CI-988 on below-level neuropathic pain after spinal cord injury in rats. We also examined the interaction of morphine and CI-988 in the antinociceptive effect. Both morphine and CI-988 given individually increased the paw withdrawal threshold to mechanical stimulation in a dose-dependent manner. The combination of ineffective doses of intrathecally administered CI-988 and morphine produced significant analgesic effects and the combination of effective doses resulted in analgesic effects that were greater than the sum of the individual effects of each drug. Thus, morphine showed a synergistic interaction with CI-988 for analgesia of central neuropathic pain.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalKorean Journal of Physiology and Pharmacology
Volume19
Issue number2
DOIs
Publication statusPublished - 2015 Mar 1

Keywords

  • Cholecystokinin
  • Morphine
  • Neuropathic pain
  • Spinal cord injury
  • Synergistic interaction

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

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