Effect of the hesperetin and naringenin on pp60v-src-induced NF-κB activation

O. Song Kwon, Bo Yeon Kim, Kyoung A. Kim, Min Soo Kim, HyunCheol Oh, Beom Seok Kim, Young Ho Kim, Jong Seog Ahn

Research output: Contribution to journalArticle

Abstract

The effects of hesperetin and naringenin on NF-κB activation were investigated in normal rat kidney cells transformed by temperature sensitive Rous Sarcoma Virus (tsNRK). The flavonoids, naringenin and hesperetin, significantly reduced v-Src-induced NF-κB activation as well as phosphorylation of Akt and GSK-3 in tsNRK cells, whereas these compounds did not effect on platelet-derived growth factor (PDGF)-induced NF-κB activation in NIH3T3γ1 cells. In addition, the DNA binding activity of SP-1 was also reduced but that of AP-1 was not affected by the compounds. Our study suggests that Src-induced NF-κB activation could occur via Akt-GSK-3 pathway without IκBα degradation and that naringenin and hesperetin could be used in the treatment of cancer through the inhibition of NF-κB activation.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalKorean Journal of Pharmacognosy
Volume35
Issue number3
Publication statusPublished - 2004 Sep 1
Externally publishedYes

Fingerprint

Glycogen Synthase Kinase 3
Rous sarcoma virus
Platelet-Derived Growth Factor
Transcription Factor AP-1
Flavonoids
Phosphorylation
Kidney
Temperature
DNA
naringenin
hesperetin
Neoplasms

Keywords

  • Akt
  • Flavonoid
  • GSK-3
  • Hesperetin
  • IκBα
  • Naringenin
  • NF-κB
  • v-Src

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Kwon, O. S., Kim, B. Y., Kim, K. A., Kim, M. S., Oh, H., Kim, B. S., ... Ahn, J. S. (2004). Effect of the hesperetin and naringenin on pp60v-src-induced NF-κB activation. Korean Journal of Pharmacognosy, 35(3), 244-249.

Effect of the hesperetin and naringenin on pp60v-src-induced NF-κB activation. / Kwon, O. Song; Kim, Bo Yeon; Kim, Kyoung A.; Kim, Min Soo; Oh, HyunCheol; Kim, Beom Seok; Kim, Young Ho; Ahn, Jong Seog.

In: Korean Journal of Pharmacognosy, Vol. 35, No. 3, 01.09.2004, p. 244-249.

Research output: Contribution to journalArticle

Kwon, OS, Kim, BY, Kim, KA, Kim, MS, Oh, H, Kim, BS, Kim, YH & Ahn, JS 2004, 'Effect of the hesperetin and naringenin on pp60v-src-induced NF-κB activation', Korean Journal of Pharmacognosy, vol. 35, no. 3, pp. 244-249.
Kwon, O. Song ; Kim, Bo Yeon ; Kim, Kyoung A. ; Kim, Min Soo ; Oh, HyunCheol ; Kim, Beom Seok ; Kim, Young Ho ; Ahn, Jong Seog. / Effect of the hesperetin and naringenin on pp60v-src-induced NF-κB activation. In: Korean Journal of Pharmacognosy. 2004 ; Vol. 35, No. 3. pp. 244-249.
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