Effect of the hesperetin and naringenin on pp60v-src-induced NF-κB activation

O. Song Kwon, Bo Yeon Kim, Kyoung A. Kim, Min Soo Kim, Hyun Cheol Oh, Beom Seok Kim, Young Ho Kim, Jong Seog Ahn

Research output: Contribution to journalArticle

Abstract

The effects of hesperetin and naringenin on NF-κB activation were investigated in normal rat kidney cells transformed by temperature sensitive Rous Sarcoma Virus (tsNRK). The flavonoids, naringenin and hesperetin, significantly reduced v-Src-induced NF-κB activation as well as phosphorylation of Akt and GSK-3 in tsNRK cells, whereas these compounds did not effect on platelet-derived growth factor (PDGF)-induced NF-κB activation in NIH3T3γ1 cells. In addition, the DNA binding activity of SP-1 was also reduced but that of AP-1 was not affected by the compounds. Our study suggests that Src-induced NF-κB activation could occur via Akt-GSK-3 pathway without IκBα degradation and that naringenin and hesperetin could be used in the treatment of cancer through the inhibition of NF-κB activation.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalKorean Journal of Pharmacognosy
Volume35
Issue number3
Publication statusPublished - 2004 Sep
Externally publishedYes

Keywords

  • Akt
  • Flavonoid
  • GSK-3
  • Hesperetin
  • IκBα
  • NF-κB
  • Naringenin
  • v-Src

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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  • Cite this

    Kwon, O. S., Kim, B. Y., Kim, K. A., Kim, M. S., Oh, H. C., Kim, B. S., Kim, Y. H., & Ahn, J. S. (2004). Effect of the hesperetin and naringenin on pp60v-src-induced NF-κB activation. Korean Journal of Pharmacognosy, 35(3), 244-249.