Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss

Sun Hye Jung, Hye Soon Park, Kyung Soo Kim, Woong H. Choi, Chul Woo Ahn, Bom Taeck Kim, Seon Mee Kim, Seon Yeong Lee, Sang Mi Ahn, Yun Kyung Kim, Hae Jin Kim, Dae Jung Kim, Kwan Woo Lee

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108 Citations (Scopus)

Abstract

Obesity is a major risk factor for hypertension, coronary artery disease and type 2 diabetes. Weight loss is associated with significant metabolic benefits. Our objective was to examine changes in adipocytokines and interleukin (IL) 10 in obese subjects before and after weight loss. We measured anthropometric parameters, adipocytokine and IL-10 in 78 obese people who had visited obesity clinics at five university hospitals (Ajou, Ulsan, Catholic, Hanyang and Yonsei) in Korea. They restricted their caloric intake to less than their usual intake (by 500kcal), were administered sibutramine and were given a program of exercise for 12 weeks. After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor α (TNF-α), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased. A bivariate correlation analysis found that increment in IL-10 and baseline IL-10 levels significantly correlated with decrement in TNF-α (P<.01) and baseline adiponectin (r=.52, P<.001), respectively. These results were confirmed in a multiple regression analysis. The results suggest that weight loss after caloric restriction and medical treatment in obesity can improve metabolic risk factors through changes in some cytokines.

Original languageEnglish
Pages (from-to)371-375
Number of pages5
JournalJournal of Nutritional Biochemistry
Volume19
Issue number6
DOIs
Publication statusPublished - 2008 Jun 1

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Keywords

  • Adipocytokines (adipokines)
  • Interleukin (IL) 10
  • Weight loss

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Jung, S. H., Park, H. S., Kim, K. S., Choi, W. H., Ahn, C. W., Kim, B. T., Kim, S. M., Lee, S. Y., Ahn, S. M., Kim, Y. K., Kim, H. J., Kim, D. J., & Lee, K. W. (2008). Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss. Journal of Nutritional Biochemistry, 19(6), 371-375. https://doi.org/10.1016/j.jnutbio.2007.05.007