TY - JOUR
T1 - Effect of weight loss on some serum cytokines in human obesity
T2 - increase in IL-10 after weight loss
AU - Jung, Sun Hye
AU - Park, Hye Soon
AU - Kim, Kyung Soo
AU - Choi, Woong H.
AU - Ahn, Chul Woo
AU - Kim, Bom Taeck
AU - Kim, Seon Mee
AU - Lee, Seon Yeong
AU - Ahn, Sang Mi
AU - Kim, Yun Kyung
AU - Kim, Hae Jin
AU - Kim, Dae Jung
AU - Lee, Kwan Woo
N1 - Funding Information:
This work was supported by a 2003 grant from the Department of Medical Sciences, The Graduate School, Ajou University; the “GRRC” project of the Gyeonggi Provincial Government; and a grant from the Korean Health 21 R&D Project, Ministry of Health and Welfare (A050463), Republic of Korea (to K.W. Lee).
PY - 2008/6
Y1 - 2008/6
N2 - Obesity is a major risk factor for hypertension, coronary artery disease and type 2 diabetes. Weight loss is associated with significant metabolic benefits. Our objective was to examine changes in adipocytokines and interleukin (IL) 10 in obese subjects before and after weight loss. We measured anthropometric parameters, adipocytokine and IL-10 in 78 obese people who had visited obesity clinics at five university hospitals (Ajou, Ulsan, Catholic, Hanyang and Yonsei) in Korea. They restricted their caloric intake to less than their usual intake (by 500kcal), were administered sibutramine and were given a program of exercise for 12 weeks. After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor α (TNF-α), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased. A bivariate correlation analysis found that increment in IL-10 and baseline IL-10 levels significantly correlated with decrement in TNF-α (P<.01) and baseline adiponectin (r=.52, P<.001), respectively. These results were confirmed in a multiple regression analysis. The results suggest that weight loss after caloric restriction and medical treatment in obesity can improve metabolic risk factors through changes in some cytokines.
AB - Obesity is a major risk factor for hypertension, coronary artery disease and type 2 diabetes. Weight loss is associated with significant metabolic benefits. Our objective was to examine changes in adipocytokines and interleukin (IL) 10 in obese subjects before and after weight loss. We measured anthropometric parameters, adipocytokine and IL-10 in 78 obese people who had visited obesity clinics at five university hospitals (Ajou, Ulsan, Catholic, Hanyang and Yonsei) in Korea. They restricted their caloric intake to less than their usual intake (by 500kcal), were administered sibutramine and were given a program of exercise for 12 weeks. After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor α (TNF-α), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased. A bivariate correlation analysis found that increment in IL-10 and baseline IL-10 levels significantly correlated with decrement in TNF-α (P<.01) and baseline adiponectin (r=.52, P<.001), respectively. These results were confirmed in a multiple regression analysis. The results suggest that weight loss after caloric restriction and medical treatment in obesity can improve metabolic risk factors through changes in some cytokines.
KW - Adipocytokines (adipokines)
KW - Interleukin (IL) 10
KW - Weight loss
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UR - http://www.scopus.com/inward/citedby.url?scp=43849098207&partnerID=8YFLogxK
U2 - 10.1016/j.jnutbio.2007.05.007
DO - 10.1016/j.jnutbio.2007.05.007
M3 - Article
C2 - 17614271
AN - SCOPUS:43849098207
VL - 19
SP - 371
EP - 375
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
SN - 0955-2863
IS - 6
ER -
