Abstract
Obesity is a major risk factor for hypertension, coronary artery disease and type 2 diabetes. Weight loss is associated with significant metabolic benefits. Our objective was to examine changes in adipocytokines and interleukin (IL) 10 in obese subjects before and after weight loss. We measured anthropometric parameters, adipocytokine and IL-10 in 78 obese people who had visited obesity clinics at five university hospitals (Ajou, Ulsan, Catholic, Hanyang and Yonsei) in Korea. They restricted their caloric intake to less than their usual intake (by 500kcal), were administered sibutramine and were given a program of exercise for 12 weeks. After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor α (TNF-α), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased. A bivariate correlation analysis found that increment in IL-10 and baseline IL-10 levels significantly correlated with decrement in TNF-α (P<.01) and baseline adiponectin (r=.52, P<.001), respectively. These results were confirmed in a multiple regression analysis. The results suggest that weight loss after caloric restriction and medical treatment in obesity can improve metabolic risk factors through changes in some cytokines.
| Original language | English |
|---|---|
| Pages (from-to) | 371-375 |
| Number of pages | 5 |
| Journal | Journal of Nutritional Biochemistry |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2008 Jun 1 |
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Keywords
- Adipocytokines (adipokines)
- Interleukin (IL) 10
- Weight loss
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Molecular Biology
- Nutrition and Dietetics
- Clinical Biochemistry
Cite this
Effect of weight loss on some serum cytokines in human obesity : increase in IL-10 after weight loss. / Jung, Sun Hye; Park, Hye Soon; Kim, Kyung Soo; Choi, Woong H.; Ahn, Chul Woo; Kim, Bom Taeck; Kim, Seon Mee; Lee, Seon Yeong; Ahn, Sang Mi; Kim, Yun Kyung; Kim, Hae Jin; Kim, Dae Jung; Lee, Kwan Woo.
In: Journal of Nutritional Biochemistry, Vol. 19, No. 6, 01.06.2008, p. 371-375.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of weight loss on some serum cytokines in human obesity
T2 - increase in IL-10 after weight loss
AU - Jung, Sun Hye
AU - Park, Hye Soon
AU - Kim, Kyung Soo
AU - Choi, Woong H.
AU - Ahn, Chul Woo
AU - Kim, Bom Taeck
AU - Kim, Seon Mee
AU - Lee, Seon Yeong
AU - Ahn, Sang Mi
AU - Kim, Yun Kyung
AU - Kim, Hae Jin
AU - Kim, Dae Jung
AU - Lee, Kwan Woo
PY - 2008/6/1
Y1 - 2008/6/1
N2 - Obesity is a major risk factor for hypertension, coronary artery disease and type 2 diabetes. Weight loss is associated with significant metabolic benefits. Our objective was to examine changes in adipocytokines and interleukin (IL) 10 in obese subjects before and after weight loss. We measured anthropometric parameters, adipocytokine and IL-10 in 78 obese people who had visited obesity clinics at five university hospitals (Ajou, Ulsan, Catholic, Hanyang and Yonsei) in Korea. They restricted their caloric intake to less than their usual intake (by 500kcal), were administered sibutramine and were given a program of exercise for 12 weeks. After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor α (TNF-α), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased. A bivariate correlation analysis found that increment in IL-10 and baseline IL-10 levels significantly correlated with decrement in TNF-α (P<.01) and baseline adiponectin (r=.52, P<.001), respectively. These results were confirmed in a multiple regression analysis. The results suggest that weight loss after caloric restriction and medical treatment in obesity can improve metabolic risk factors through changes in some cytokines.
AB - Obesity is a major risk factor for hypertension, coronary artery disease and type 2 diabetes. Weight loss is associated with significant metabolic benefits. Our objective was to examine changes in adipocytokines and interleukin (IL) 10 in obese subjects before and after weight loss. We measured anthropometric parameters, adipocytokine and IL-10 in 78 obese people who had visited obesity clinics at five university hospitals (Ajou, Ulsan, Catholic, Hanyang and Yonsei) in Korea. They restricted their caloric intake to less than their usual intake (by 500kcal), were administered sibutramine and were given a program of exercise for 12 weeks. After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor α (TNF-α), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased. A bivariate correlation analysis found that increment in IL-10 and baseline IL-10 levels significantly correlated with decrement in TNF-α (P<.01) and baseline adiponectin (r=.52, P<.001), respectively. These results were confirmed in a multiple regression analysis. The results suggest that weight loss after caloric restriction and medical treatment in obesity can improve metabolic risk factors through changes in some cytokines.
KW - Adipocytokines (adipokines)
KW - Interleukin (IL) 10
KW - Weight loss
UR - http://www.scopus.com/inward/record.url?scp=43849098207&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43849098207&partnerID=8YFLogxK
U2 - 10.1016/j.jnutbio.2007.05.007
DO - 10.1016/j.jnutbio.2007.05.007
M3 - Article
VL - 19
SP - 371
EP - 375
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
SN - 0955-2863
IS - 6
ER -