Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats

Jeong Sup Hong, Myeong Kyu Park, Min Seok Kim, Jeong Hyeon Lim, Gil Jong Park, Eun Ho Maeng, Jae Ho Shin, Yu Ri Kim, Meyoung-Kon Kim, Jong Kwon Lee, Jin A. Park, Jong Choon Kim, Ho Chul Shin

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This study investigated the potential adverse effects of zinc oxide nanoparticles (ZnOSM20[-] NPs; negatively charged, 20 nm) on pregnant dams and embryo–fetal development after maternal exposure over the period of gestational days 5–19 with Sprague Dawley rats. ZnOSM20(-) NPs were administered to pregnant rats by gavage at 0 mg/kg/day, 100 mg/kg/day, 200 mg/kg/day, and 400 mg/kg/day. All dams were subjected to caesarean section on gestational day 20, and all the fetuses were examined for external, visceral, and skeletal alterations. Toxicity in the dams manifested as significantly decreased body weight at 400 mg/kg/day and decreased liver weight, and increased adrenal glands weight at 200 mg/kg/day and 400 mg/kg/day. However, no treatment-related difference in the number of corpora lutea, the number of implantation sites, the implantation rate (%), resorption, dead fetuses, litter size, fetal deaths, fetal and placental weights, and sex ratio were observed between the groups. Morphological examinations of the fetuses demonstrated no significant difference in the incidences of abnormalities between the groups. No significant difference was found in the Zn content of fetal tissue between the control and high-dose groups. These results showed that a 15-day repeated oral dose of ZnOSM20(-) was minimally maternotoxic at dose of 200 mg/kg/day and 400 mg/kg/day.

Original languageEnglish
Pages (from-to)145-157
Number of pages13
JournalInternational Journal of Nanomedicine
Volume9
DOIs
Publication statusPublished - 2014 Dec 15

Fingerprint

Zinc Oxide
Zinc oxide
Nanoparticles
Dams
Rats
Fetus
Maternal Exposure
Weights and Measures
Liver
Litter Size
Fetal Weight
Fetal Death
Toxicity
Corpus Luteum
Sex Ratio
Adrenal Glands
Cesarean Section
Tissue
Sprague Dawley Rats
Body Weight

Keywords

  • Developmental toxicity
  • Maternal toxicity
  • Nanoparticles
  • Nanotoxicology
  • Teratogenicity
  • Zinc oxide

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Drug Discovery
  • Organic Chemistry

Cite this

Hong, J. S., Park, M. K., Kim, M. S., Lim, J. H., Park, G. J., Maeng, E. H., ... Shin, H. C. (2014). Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats. International Journal of Nanomedicine, 9, 145-157. https://doi.org/10.2147/IJN.S57931

Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats. / Hong, Jeong Sup; Park, Myeong Kyu; Kim, Min Seok; Lim, Jeong Hyeon; Park, Gil Jong; Maeng, Eun Ho; Shin, Jae Ho; Kim, Yu Ri; Kim, Meyoung-Kon; Lee, Jong Kwon; Park, Jin A.; Kim, Jong Choon; Shin, Ho Chul.

In: International Journal of Nanomedicine, Vol. 9, 15.12.2014, p. 145-157.

Research output: Contribution to journalArticle

Hong, JS, Park, MK, Kim, MS, Lim, JH, Park, GJ, Maeng, EH, Shin, JH, Kim, YR, Kim, M-K, Lee, JK, Park, JA, Kim, JC & Shin, HC 2014, 'Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats', International Journal of Nanomedicine, vol. 9, pp. 145-157. https://doi.org/10.2147/IJN.S57931
Hong, Jeong Sup ; Park, Myeong Kyu ; Kim, Min Seok ; Lim, Jeong Hyeon ; Park, Gil Jong ; Maeng, Eun Ho ; Shin, Jae Ho ; Kim, Yu Ri ; Kim, Meyoung-Kon ; Lee, Jong Kwon ; Park, Jin A. ; Kim, Jong Choon ; Shin, Ho Chul. / Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats. In: International Journal of Nanomedicine. 2014 ; Vol. 9. pp. 145-157.
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