Effective reduction of blood cell damage by using a compliance chamber in a pulsatile extracorporeal life support system

Kyu Back Lee, Kyung Sun, Hye Won Kim, Jun Keun Chang, Chan Young Park, Chahil Chung, Jung Kyung Kim, Jongwon Kim, Hyoung Mook Kim

Research output: Contribution to journalArticle

Abstract

So far many extracorporeal life support systems (ECLS) were shown in the market, but types of their main pumps were either rotary pumps or centrifugal pumps Pulsatile pumps were usually not used due to the high hemolysis. However, pulsatile pumps have a major advantage that they are capable of synchronizing with the natural heart beat that helps to increase the coronary blood flow and decrease the load of natural heart. In this study, we tried to improve the hemolysis problem of pulsatile ECLS with a compliance chamber located between the outlet of blood pump and the inlet of membrane oxygenator. The role of the compliance chamber was simulated with a mathematical modeling of human vascular system and ECLS system. A set of animal experiment was also performed. Experimental animals were divided into 3 groups. A pulsatile pump with a compliance chamber, a pulsatile pump without a compliance chamber and a centrifugal pump without a compliance chamber were used in group 1 (6 dogs), group 2 (6 dogs) and group 3 (4 dogs) respectively. We observed the pumping capacity, gas exchange capacity and the degree of hemolysis in the acute pulmonary insufficiency animal model. After the onset of acute pulmonary insufficiency by the slow infusion of oleic acid, we started partial cardiopulmonary bypass(pCPB) and finished after 2 hrs. of pCPB. The concentration of plasma hemoglobin was measured before the animal experiments and after 2 hrs. of pCPB. We also observed several hemodynamic parameters and gas exchange parameters. The results of animal experiments show us that the hemodynamic parameters of pCPB, such as arterial pressure, central venous pressure, left atrial pressure and pulmonary capillary wedge pressure, were not significantly different among experimental groups. However, the parameters correspondent to the efficiency of gas exchange and the blood cell damage were significantly different among groups. The results of mathematical modeling also showed us that the more the amount of air in the compliance chamber, the less the fluctuation of the AoP.

Original languageEnglish
JournalASAIO Journal
Volume46
Issue number2
Publication statusPublished - 2000 Mar 1

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Life Support Systems
Extracorporeal Membrane Oxygenation
Compliance
Blood Cells
Blood
Cells
Pumps
Animals
Cardiopulmonary Bypass
Hemolysis
Gases
Centrifugal pumps
Hemodynamics
Dogs
Rotary pumps
Oxygenators
Membrane Oxygenators
Lung
Central Venous Pressure
Pulmonary Wedge Pressure

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Effective reduction of blood cell damage by using a compliance chamber in a pulsatile extracorporeal life support system. / Lee, Kyu Back; Sun, Kyung; Kim, Hye Won; Chang, Jun Keun; Park, Chan Young; Chung, Chahil; Kim, Jung Kyung; Kim, Jongwon; Kim, Hyoung Mook.

In: ASAIO Journal, Vol. 46, No. 2, 01.03.2000.

Research output: Contribution to journalArticle

Lee, Kyu Back ; Sun, Kyung ; Kim, Hye Won ; Chang, Jun Keun ; Park, Chan Young ; Chung, Chahil ; Kim, Jung Kyung ; Kim, Jongwon ; Kim, Hyoung Mook. / Effective reduction of blood cell damage by using a compliance chamber in a pulsatile extracorporeal life support system. In: ASAIO Journal. 2000 ; Vol. 46, No. 2.
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