Effective treatment with fucoidin for perinatal hypoxic-ischemic encephalopathy in rats

C. S. Uhm, K. B. Kim, J. H. Lim, D. H. Pee, Y. H. Kim, H. Kim, B. L. Eun, Y. C. Tockgo

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Leukocyte-endothelial adhesion is a key step to initiate post-ischemic reperfusion injury in many organs. In this study, we found that the expressions of P-selectin mRNA and protein were increased in the ipsilateral hemisphere with a peak at 8 h after hypoxia-ischemia in immature brain. Such temporal profiles of P-selectin expression followed by hypoxia-ischemia are consistent with a role in the subsequent brain injury. Because fucoidin is known to inhibit P/L-selectin mediated leukocyte adhesion, we examined whether the treatment of fucoidin attenuates hypoxia-ischemia-induced neural damages. Treatment with fucoidin exhibited a substantial neuroprotective effect in a dose-dependent manner and inhibited the leukocyte adhesion significantly, as revealed by myeloperoxidase activity. These results suggest that anti-adhesion strategy may be an effective therapeutic application for the perinatal hypoxic-ischemic encephalopathy.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalNeuroscience Letters
Volume353
Issue number1
DOIs
Publication statusPublished - 2003 Dec 15

Keywords

  • Fucoidin
  • Neuroprotection
  • P-selectin
  • Perinatal hypoxic-ischemic encephalopathy

ASJC Scopus subject areas

  • Neuroscience(all)

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