Effective treatment with fucoidin for perinatal hypoxic-ischemic encephalopathy in rats

C. S. Uhm; K. B. Kim; J. H. Lim; D. H. Pee; Y. H. Kim; H. Kim; B. L. Eun; Y. C. Tockgo

doi:10.1016/j.neulet.2003.09.013

Effective treatment with fucoidin for perinatal hypoxic-ischemic encephalopathy in rats

C. S. Uhm, K. B. Kim, J. H. Lim, D. H. Pee, Y. H. Kim, H. Kim, B. L. Eun, Y. C. Tockgo

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Leukocyte-endothelial adhesion is a key step to initiate post-ischemic reperfusion injury in many organs. In this study, we found that the expressions of P-selectin mRNA and protein were increased in the ipsilateral hemisphere with a peak at 8 h after hypoxia-ischemia in immature brain. Such temporal profiles of P-selectin expression followed by hypoxia-ischemia are consistent with a role in the subsequent brain injury. Because fucoidin is known to inhibit P/L-selectin mediated leukocyte adhesion, we examined whether the treatment of fucoidin attenuates hypoxia-ischemia-induced neural damages. Treatment with fucoidin exhibited a substantial neuroprotective effect in a dose-dependent manner and inhibited the leukocyte adhesion significantly, as revealed by myeloperoxidase activity. These results suggest that anti-adhesion strategy may be an effective therapeutic application for the perinatal hypoxic-ischemic encephalopathy.

Original language	English
Pages (from-to)	21-24
Number of pages	4
Journal	Neuroscience Letters
Volume	353
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2003.09.013
Publication status	Published - 2003 Dec 15

Keywords

Fucoidin
Neuroprotection
P-selectin
Perinatal hypoxic-ischemic encephalopathy

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2003.09.013

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title = "Effective treatment with fucoidin for perinatal hypoxic-ischemic encephalopathy in rats",

abstract = "Leukocyte-endothelial adhesion is a key step to initiate post-ischemic reperfusion injury in many organs. In this study, we found that the expressions of P-selectin mRNA and protein were increased in the ipsilateral hemisphere with a peak at 8 h after hypoxia-ischemia in immature brain. Such temporal profiles of P-selectin expression followed by hypoxia-ischemia are consistent with a role in the subsequent brain injury. Because fucoidin is known to inhibit P/L-selectin mediated leukocyte adhesion, we examined whether the treatment of fucoidin attenuates hypoxia-ischemia-induced neural damages. Treatment with fucoidin exhibited a substantial neuroprotective effect in a dose-dependent manner and inhibited the leukocyte adhesion significantly, as revealed by myeloperoxidase activity. These results suggest that anti-adhesion strategy may be an effective therapeutic application for the perinatal hypoxic-ischemic encephalopathy.",

keywords = "Fucoidin, Neuroprotection, P-selectin, Perinatal hypoxic-ischemic encephalopathy",

author = "Uhm, {C. S.} and Kim, {K. B.} and Lim, {J. H.} and Pee, {D. H.} and Kim, {Y. H.} and H. Kim and Eun, {B. L.} and Tockgo, {Y. C.}",

note = "Funding Information: This work is supported by grants R01-2000-000-00165-0 from the basic research program of the Korea Science and Engineering Foundation.",

year = "2003",

month = dec,

day = "15",

doi = "10.1016/j.neulet.2003.09.013",

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AU - Uhm, C. S.

AU - Kim, K. B.

AU - Lim, J. H.

AU - Pee, D. H.

AU - Kim, Y. H.

AU - Kim, H.

AU - Eun, B. L.

AU - Tockgo, Y. C.

N1 - Funding Information: This work is supported by grants R01-2000-000-00165-0 from the basic research program of the Korea Science and Engineering Foundation.

PY - 2003/12/15

Y1 - 2003/12/15

N2 - Leukocyte-endothelial adhesion is a key step to initiate post-ischemic reperfusion injury in many organs. In this study, we found that the expressions of P-selectin mRNA and protein were increased in the ipsilateral hemisphere with a peak at 8 h after hypoxia-ischemia in immature brain. Such temporal profiles of P-selectin expression followed by hypoxia-ischemia are consistent with a role in the subsequent brain injury. Because fucoidin is known to inhibit P/L-selectin mediated leukocyte adhesion, we examined whether the treatment of fucoidin attenuates hypoxia-ischemia-induced neural damages. Treatment with fucoidin exhibited a substantial neuroprotective effect in a dose-dependent manner and inhibited the leukocyte adhesion significantly, as revealed by myeloperoxidase activity. These results suggest that anti-adhesion strategy may be an effective therapeutic application for the perinatal hypoxic-ischemic encephalopathy.

AB - Leukocyte-endothelial adhesion is a key step to initiate post-ischemic reperfusion injury in many organs. In this study, we found that the expressions of P-selectin mRNA and protein were increased in the ipsilateral hemisphere with a peak at 8 h after hypoxia-ischemia in immature brain. Such temporal profiles of P-selectin expression followed by hypoxia-ischemia are consistent with a role in the subsequent brain injury. Because fucoidin is known to inhibit P/L-selectin mediated leukocyte adhesion, we examined whether the treatment of fucoidin attenuates hypoxia-ischemia-induced neural damages. Treatment with fucoidin exhibited a substantial neuroprotective effect in a dose-dependent manner and inhibited the leukocyte adhesion significantly, as revealed by myeloperoxidase activity. These results suggest that anti-adhesion strategy may be an effective therapeutic application for the perinatal hypoxic-ischemic encephalopathy.

KW - Fucoidin

KW - Neuroprotection

KW - P-selectin

KW - Perinatal hypoxic-ischemic encephalopathy

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IS - 1

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Effective treatment with fucoidin for perinatal hypoxic-ischemic encephalopathy in rats

Abstract

Keywords

ASJC Scopus subject areas

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