Effectiveness of a Fractionated Therapy Scheme in Tumor Treating Fields Therapy

Yunhui Jo, Jiwon Sung, Hyesun Jeong, Sunghoi Hong, Youn Kyoung Jeong, Eun Ho Kim, Myonggeun Yoon

Research output: Contribution to journalArticle

Abstract

This study aimed to evaluate the biological effectiveness of cancer therapy with tumor treating fields using a fractionated treatment scheme that was originally designed for radiotherapy. Discontinuous fractional tumor treating fields of an intensity of 0.9 to 1.2 V/cm and a frequency of 150 KHz were applied to U373 cancer cells and IEC6 normal cells for 3 days, with durations of 3, 6, 12, or 24 h/d. As the treatment duration of the tumor treating fields increased from 3 to 24 h/d, the relative tumor cell (U373) number (% of control) reduced in proportion to the treatment duration. Compared to a 25% cell number reduction (75% of control) for the group of 6 h/d treatment at 1.2 V/cm, only 5% (70% of control) and 8% (67% of control) of additional reductions were observed for the group of 12 and 24 h/d treatment, respectively. This experimental result indicates that the dependence on treatment duration in tumor cell inhibition was weakened distinctly at treatment duration over 6 h/d. For normal cells (IEC6), the relative cell number corresponding to the treatment time of the tumor treating fields at 1.2 V/cm of electric field strength was not decreased much for the treatment times of 3, 6, and 12 h/d, revealing 93.3%, 90.0%, and 89.3% relative cell numbers, respectively, but it suddenly decreased to ∼73% for the 24 h/d treatment. Our results showed that the effects of tumor treating fields on tumor cells were higher than on normal cells for treatment duration of 3 to 12 h/d, but the difference became minimal for treatment duration of 24 h/d. The fractionated scheme, using tumor treating fields, reduced the treatment time while maintaining efficacy, suggesting that this method may be clinically applicable for cancer treatment.

Original languageEnglish
JournalTechnology in cancer research & treatment
Volume18
DOIs
Publication statusPublished - 2019 Jan 1

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Neoplasms
Therapeutics
Cell Count
Radiotherapy
Control Groups

Keywords

  • fractionated scheme
  • glioblastoma
  • head and neck cancer
  • radiotherapy
  • tumor treating fields

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Effectiveness of a Fractionated Therapy Scheme in Tumor Treating Fields Therapy. / Jo, Yunhui; Sung, Jiwon; Jeong, Hyesun; Hong, Sunghoi; Jeong, Youn Kyoung; Kim, Eun Ho; Yoon, Myonggeun.

In: Technology in cancer research & treatment, Vol. 18, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "This study aimed to evaluate the biological effectiveness of cancer therapy with tumor treating fields using a fractionated treatment scheme that was originally designed for radiotherapy. Discontinuous fractional tumor treating fields of an intensity of 0.9 to 1.2 V/cm and a frequency of 150 KHz were applied to U373 cancer cells and IEC6 normal cells for 3 days, with durations of 3, 6, 12, or 24 h/d. As the treatment duration of the tumor treating fields increased from 3 to 24 h/d, the relative tumor cell (U373) number ({\%} of control) reduced in proportion to the treatment duration. Compared to a 25{\%} cell number reduction (75{\%} of control) for the group of 6 h/d treatment at 1.2 V/cm, only 5{\%} (70{\%} of control) and 8{\%} (67{\%} of control) of additional reductions were observed for the group of 12 and 24 h/d treatment, respectively. This experimental result indicates that the dependence on treatment duration in tumor cell inhibition was weakened distinctly at treatment duration over 6 h/d. For normal cells (IEC6), the relative cell number corresponding to the treatment time of the tumor treating fields at 1.2 V/cm of electric field strength was not decreased much for the treatment times of 3, 6, and 12 h/d, revealing 93.3{\%}, 90.0{\%}, and 89.3{\%} relative cell numbers, respectively, but it suddenly decreased to ∼73{\%} for the 24 h/d treatment. Our results showed that the effects of tumor treating fields on tumor cells were higher than on normal cells for treatment duration of 3 to 12 h/d, but the difference became minimal for treatment duration of 24 h/d. The fractionated scheme, using tumor treating fields, reduced the treatment time while maintaining efficacy, suggesting that this method may be clinically applicable for cancer treatment.",
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