Effectiveness of three times daily lansoprazole/amoxicillin dual therapy for Helicobacter pylori infection in Korea

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Abstract

AIM: We compared three times daily dual therapy with standard triple therapy for effectiveness and safety in H.pylori infection. METHODS: Two hundred and four H.pylori positive patients with peptic ulcer were randomly assigned to one of two regimens: (i) triple therapy with amoxicillin, clarithromycin and lansoprazole twice daily for 2 weeks or (ii) dual therapy with amoxicillin and lansoprazole three times daily for 2 weeks. The success of eradication was evaluated 4 to 5 weeks after completing treatment. RESULTS: The eradication rate was 82.8% in the triple therapy group and 78.4% in the dual therapy group by per protocol analysis. This difference was not significant (P= 0.573). Adverse events were more frequent in the triple therapy group than in the dual therapy group (P= 0.002). CONCLUSIONS: Because dual therapy had fewer side effects than triple therapy and a similar eradication rate, dual therapy may provide an acceptable alternative first line therapy for H.pylori eradication in Korea.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume73
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Keywords

  • Amoxicillin/administration and dosage
  • Combination
  • Drug therapy
  • Helicobacter pylori/drug therapy
  • Proton pump inhibitors/administration and dosage

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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