Effectiveness of three times daily lansoprazole/amoxicillin dual therapy for Helicobacter pylori infection in Korea

Seung Young Kim, Sung Woo Jung, Jeong Han Kim, Ja Seol Koo, Hyung Joon Yim, Jong Jae Park, Hoon Jai Chun, Sang Woo Lee, Jai Hyun Choi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

AIM: We compared three times daily dual therapy with standard triple therapy for effectiveness and safety in H.pylori infection. METHODS: Two hundred and four H.pylori positive patients with peptic ulcer were randomly assigned to one of two regimens: (i) triple therapy with amoxicillin, clarithromycin and lansoprazole twice daily for 2 weeks or (ii) dual therapy with amoxicillin and lansoprazole three times daily for 2 weeks. The success of eradication was evaluated 4 to 5 weeks after completing treatment. RESULTS: The eradication rate was 82.8% in the triple therapy group and 78.4% in the dual therapy group by per protocol analysis. This difference was not significant (P= 0.573). Adverse events were more frequent in the triple therapy group than in the dual therapy group (P= 0.002). CONCLUSIONS: Because dual therapy had fewer side effects than triple therapy and a similar eradication rate, dual therapy may provide an acceptable alternative first line therapy for H.pylori eradication in Korea.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume73
Issue number1
DOIs
Publication statusPublished - 2012 Jan

Keywords

  • Amoxicillin/administration and dosage
  • Combination
  • Drug therapy
  • Helicobacter pylori/drug therapy
  • Proton pump inhibitors/administration and dosage

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Kim, S. Y., Jung, S. W., Kim, J. H., Koo, J. S., Yim, H. J., Park, J. J., Chun, H. J., Lee, S. W., & Choi, J. H. (2012). Effectiveness of three times daily lansoprazole/amoxicillin dual therapy for Helicobacter pylori infection in Korea. British Journal of Clinical Pharmacology, 73(1), 140-143. https://doi.org/10.1111/j.1365-2125.2011.04048.x