Effects of α1- and α2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain

Sun Kwang Kim, Byung Il Min, Ji Hoon Kim, Byung Gil Hwang, Gi Yong Yoo, Dong Suk Park, Heung Sik Na

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Systemic administrations (0.1, 0.5, and 2 mg/kg) of α1-adrenoreceptor (AR) antagonist prazosin dose-dependently attenuated cold allodynia in a rat tail model of neuropathic pain, whereas α2-AR antagonist yohimbine exacerbated it. These results suggest that the functions of α1- and α2-AR in this model are excitatory and inhibitory, respectively, consistent with their general properties. It is also proposed that cold allodynia can be reversed by α1-AR antagonist and exacerbated by α2-AR antagonist.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalBrain Research
Volume1039
Issue number1-2
DOIs
Publication statusPublished - 2005 Mar 28

Keywords

  • Cold allodynia
  • Neuropathic pain
  • Prazosin
  • Yohimbine
  • α1-adrenoreceptor
  • α2-adrenoreceptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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