Effects of 1,8-cineole on hypertension induced by chronic exposure to nicotine in rats

Hea Kyung Moon, Purum Kang, Hui Su Lee, Sun Seek Min, Geun Hee Seol

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives The monoterpenic oxide 1,8-cineole is a major component of many essential oils. We investigated its effects on systolic blood pressure (SBP) and oxidative stress in rats chronically exposed to nicotine. Methods Male Sprague-Dawley rats (100-120 g) were intraperitoneally injected with 0.8 mg/kg/day nicotine for 21 days, followed by 3 mg/kg nicotine the next day. Rats were subsequently injected intraperitoneally with 0.01, 0.1 and 1 mg/kg 1,8-cineole, or 10 mg/kg nifedipine. SBP was measured using a tail cuff transducer, plasma nitrite concentration was measured colorimetrically, and plasma corticosterone concentration was measured by enzyme immunoassay. Key findings We found that 0.1 mg/kg 1,8-cineole significantly reduced SBP, and that 1.0 mg/kg 1,8-cineole significantly increased plasma nitrite concentrations, compared with rats chronically exposed to nicotine alone. Rats chronically exposed to nicotine showed a significant increase in lipid peroxidation levels, an elevation significantly antagonized by treatment with 0.01 mg/kg and 0.1 mg/kg 1,8-cineole. Chronic exposure to nicotine also significantly increased plasma corticosterone levels, but this effect was not diminished by treatment with 1,8-cineole. Conclusions These results indicate that 1,8-cineole may lower blood pressure, and that this antihypertensive effect may be associated with the regulation of nitric oxide and oxidative stress in rats chronically exposed to nicotine.

Original languageEnglish
Pages (from-to)688-693
Number of pages6
JournalJournal of Pharmacy and Pharmacology
Volume66
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Nicotine
Blood Pressure
Hypertension
Corticosterone
Nitrites
Oxidative Stress
Volatile Oils
Nifedipine
eucalyptol
Transducers
Immunoenzyme Techniques
Oxides
Antihypertensive Agents
Lipid Peroxidation
Sprague Dawley Rats
Tail
Nitric Oxide
Therapeutics

Keywords

  • 1,8-cineole
  • corticosterone
  • hypertension
  • nicotine
  • nitrite

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Effects of 1,8-cineole on hypertension induced by chronic exposure to nicotine in rats. / Moon, Hea Kyung; Kang, Purum; Lee, Hui Su; Min, Sun Seek; Seol, Geun Hee.

In: Journal of Pharmacy and Pharmacology, Vol. 66, No. 5, 01.01.2014, p. 688-693.

Research output: Contribution to journalArticle

Moon, Hea Kyung ; Kang, Purum ; Lee, Hui Su ; Min, Sun Seek ; Seol, Geun Hee. / Effects of 1,8-cineole on hypertension induced by chronic exposure to nicotine in rats. In: Journal of Pharmacy and Pharmacology. 2014 ; Vol. 66, No. 5. pp. 688-693.
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abstract = "Objectives The monoterpenic oxide 1,8-cineole is a major component of many essential oils. We investigated its effects on systolic blood pressure (SBP) and oxidative stress in rats chronically exposed to nicotine. Methods Male Sprague-Dawley rats (100-120 g) were intraperitoneally injected with 0.8 mg/kg/day nicotine for 21 days, followed by 3 mg/kg nicotine the next day. Rats were subsequently injected intraperitoneally with 0.01, 0.1 and 1 mg/kg 1,8-cineole, or 10 mg/kg nifedipine. SBP was measured using a tail cuff transducer, plasma nitrite concentration was measured colorimetrically, and plasma corticosterone concentration was measured by enzyme immunoassay. Key findings We found that 0.1 mg/kg 1,8-cineole significantly reduced SBP, and that 1.0 mg/kg 1,8-cineole significantly increased plasma nitrite concentrations, compared with rats chronically exposed to nicotine alone. Rats chronically exposed to nicotine showed a significant increase in lipid peroxidation levels, an elevation significantly antagonized by treatment with 0.01 mg/kg and 0.1 mg/kg 1,8-cineole. Chronic exposure to nicotine also significantly increased plasma corticosterone levels, but this effect was not diminished by treatment with 1,8-cineole. Conclusions These results indicate that 1,8-cineole may lower blood pressure, and that this antihypertensive effect may be associated with the regulation of nitric oxide and oxidative stress in rats chronically exposed to nicotine.",
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