Effects of 837 and 1950MHz radiofrequency radiation exposure alone or combined on oxidative stress in MCF10A cells

Mi Na Hong, Bong Cho Kim, Young-Gyu Ko, Yun Sil Lee, Seung Cheol Hong, Taehong Kim, Jeong Ki Pack, Hyung Do Choi, Nam Kim, Jae Seon Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The aim of this study was to determine whether the exposure to either single or multiple radio-frequency (RF) radiation frequencies could induce oxidative stress in cell cultures. Exposures of human MCF10A mammary epithelial cells to either a single frequency (837MHz alone or 1950MHz alone) or multiple frequencies (837 and 1950MHz) were conducted at specific absorption rate (SAR) values of 4W/kg for 2h. During the exposure period, the temperature in the exposure chamber was maintained isothermally. Intracellular levels of reactive oxygen species (ROS), the antioxidant enzyme activity of superoxide dismutase (SOD), and the ratio of reduced/oxidized glutathione (GSH/GSSG) showed no statistically significant alterations as the result of either single or multiple RF radiation exposures. In contrast, ionizing radiation-exposed cells, used as a positive control, showed evident changes in all measured biological endpoints. These results indicate that single or multiple RF radiation exposure did not elicit oxidative stress in MCF10A cells under our exposure conditions.

Original languageEnglish
Pages (from-to)604-611
Number of pages8
JournalBioelectromagnetics
Volume33
Issue number7
DOIs
Publication statusPublished - 2012 Oct 1

Fingerprint

Radio
Oxidative Stress
Glutathione Disulfide
Ionizing Radiation
Superoxide Dismutase
Glutathione
Reactive Oxygen Species
Breast
Cell Culture Techniques
Antioxidants
Epithelial Cells
Radiation
Temperature
Enzymes
Radiation Exposure

Keywords

  • MCF10A
  • Multiple exposure
  • Oxidative stress
  • RF radiation

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physiology

Cite this

Effects of 837 and 1950MHz radiofrequency radiation exposure alone or combined on oxidative stress in MCF10A cells. / Hong, Mi Na; Kim, Bong Cho; Ko, Young-Gyu; Lee, Yun Sil; Hong, Seung Cheol; Kim, Taehong; Pack, Jeong Ki; Choi, Hyung Do; Kim, Nam; Lee, Jae Seon.

In: Bioelectromagnetics, Vol. 33, No. 7, 01.10.2012, p. 604-611.

Research output: Contribution to journalArticle

Hong, MN, Kim, BC, Ko, Y-G, Lee, YS, Hong, SC, Kim, T, Pack, JK, Choi, HD, Kim, N & Lee, JS 2012, 'Effects of 837 and 1950MHz radiofrequency radiation exposure alone or combined on oxidative stress in MCF10A cells', Bioelectromagnetics, vol. 33, no. 7, pp. 604-611. https://doi.org/10.1002/bem.21731
Hong, Mi Na ; Kim, Bong Cho ; Ko, Young-Gyu ; Lee, Yun Sil ; Hong, Seung Cheol ; Kim, Taehong ; Pack, Jeong Ki ; Choi, Hyung Do ; Kim, Nam ; Lee, Jae Seon. / Effects of 837 and 1950MHz radiofrequency radiation exposure alone or combined on oxidative stress in MCF10A cells. In: Bioelectromagnetics. 2012 ; Vol. 33, No. 7. pp. 604-611.
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