Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels

Hae Yoon Choi, Ji Woo Park, Namseok Lee, Soon Young Hwang, Geum-Joon Cho, Ho Cheol Hong, Hye-Jin Yoo, Taek Geun Hwang, Seon Mee Kim, Sei-Hyun Baik, Kyong Soo Park, Byung Soo Youn, Kyung Mook Choi

Research output: Contribution to journalArticle

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Abstract

Objective-To examine the effect of a combined exercise program on C1q/tumor necrosis factor-related protein (CTRP) 3 and CTRP-5 levels and novel adiponectin paralogs suggested to be links between metabolism and inflammation and to evaluate sex differences and association with cardiometabolic risk factors in humans with use of a newly developed ELISA. RESEARCH DESIGN ANDMETHODSdThis cross-sectional study explored the implications of CTRP-3 and CTRP-5 on cardiometabolic parameters in 453 nondiabetic Korean adults. In addition, we evaluated the impact of a 3-month combined exercise program on CTRP-3 and CTRP-5 levels in 76 obese women. The exercise program consisted of 45 min of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (300 kcal/session) and 20 min of resistance training (100 kcal/session) five times per week. Results-Both CTRP-3 and CTRP-5 concentrations were significantly higher in women (P , 0.001) than in men (P = 0.030). In a multiple stepwise regression analysis, CTRP-3 levels were independently associated with age, sex, and triglyceride, LDL cholesterol, adiponectin, and retinol-binding protein 4 (RBP4) levels (R2 = 0.182). After 3 months of a combined exercise program, cardiometabolic risk factors, including components of metabolic syndrome, insulin resistance, and RBP4 levels, decreased significantly. In particular, CTRP-3 levels decreased significantly (median [interquartile range] 444.3 [373.8-535.0] to 374.4 [297.2-435.9], P < 0.001), whereas CTRP-5 levels were slightly increased (34.1 [28.6-44.3] to 38.4 [29.8-55.1], P = 0.048). Conclusions-A 3-month combined exercise program significantly decreased CTRP-3 levels and modestly increased CTRP-5 levels in obese Korean women.

Original languageEnglish
Pages (from-to)3321-3327
Number of pages7
JournalDiabetes Care
Volume36
Issue number10
DOIs
Publication statusPublished - 2013 Oct 1

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Tumor Necrosis Factor-alpha
Exercise
Proteins
Retinol-Binding Proteins
Adiponectin
Resistance Training
Sex Characteristics
LDL Cholesterol
Insulin Resistance
Triglycerides
Cross-Sectional Studies
Heart Rate
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Inflammation

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. / Choi, Hae Yoon; Park, Ji Woo; Lee, Namseok; Hwang, Soon Young; Cho, Geum-Joon; Hong, Ho Cheol; Yoo, Hye-Jin; Hwang, Taek Geun; Kim, Seon Mee; Baik, Sei-Hyun; Park, Kyong Soo; Youn, Byung Soo; Choi, Kyung Mook.

In: Diabetes Care, Vol. 36, No. 10, 01.10.2013, p. 3321-3327.

Research output: Contribution to journalArticle

Choi, Hae Yoon ; Park, Ji Woo ; Lee, Namseok ; Hwang, Soon Young ; Cho, Geum-Joon ; Hong, Ho Cheol ; Yoo, Hye-Jin ; Hwang, Taek Geun ; Kim, Seon Mee ; Baik, Sei-Hyun ; Park, Kyong Soo ; Youn, Byung Soo ; Choi, Kyung Mook. / Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. In: Diabetes Care. 2013 ; Vol. 36, No. 10. pp. 3321-3327.
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abstract = "Objective-To examine the effect of a combined exercise program on C1q/tumor necrosis factor-related protein (CTRP) 3 and CTRP-5 levels and novel adiponectin paralogs suggested to be links between metabolism and inflammation and to evaluate sex differences and association with cardiometabolic risk factors in humans with use of a newly developed ELISA. RESEARCH DESIGN ANDMETHODSdThis cross-sectional study explored the implications of CTRP-3 and CTRP-5 on cardiometabolic parameters in 453 nondiabetic Korean adults. In addition, we evaluated the impact of a 3-month combined exercise program on CTRP-3 and CTRP-5 levels in 76 obese women. The exercise program consisted of 45 min of aerobic exercise at an intensity of 60-75{\%} of the age-predicted maximum heart rate (300 kcal/session) and 20 min of resistance training (100 kcal/session) five times per week. Results-Both CTRP-3 and CTRP-5 concentrations were significantly higher in women (P , 0.001) than in men (P = 0.030). In a multiple stepwise regression analysis, CTRP-3 levels were independently associated with age, sex, and triglyceride, LDL cholesterol, adiponectin, and retinol-binding protein 4 (RBP4) levels (R2 = 0.182). After 3 months of a combined exercise program, cardiometabolic risk factors, including components of metabolic syndrome, insulin resistance, and RBP4 levels, decreased significantly. In particular, CTRP-3 levels decreased significantly (median [interquartile range] 444.3 [373.8-535.0] to 374.4 [297.2-435.9], P < 0.001), whereas CTRP-5 levels were slightly increased (34.1 [28.6-44.3] to 38.4 [29.8-55.1], P = 0.048). Conclusions-A 3-month combined exercise program significantly decreased CTRP-3 levels and modestly increased CTRP-5 levels in obese Korean women.",
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AU - Park, Ji Woo

AU - Lee, Namseok

AU - Hwang, Soon Young

AU - Cho, Geum-Joon

AU - Hong, Ho Cheol

AU - Yoo, Hye-Jin

AU - Hwang, Taek Geun

AU - Kim, Seon Mee

AU - Baik, Sei-Hyun

AU - Park, Kyong Soo

AU - Youn, Byung Soo

AU - Choi, Kyung Mook

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AB - Objective-To examine the effect of a combined exercise program on C1q/tumor necrosis factor-related protein (CTRP) 3 and CTRP-5 levels and novel adiponectin paralogs suggested to be links between metabolism and inflammation and to evaluate sex differences and association with cardiometabolic risk factors in humans with use of a newly developed ELISA. RESEARCH DESIGN ANDMETHODSdThis cross-sectional study explored the implications of CTRP-3 and CTRP-5 on cardiometabolic parameters in 453 nondiabetic Korean adults. In addition, we evaluated the impact of a 3-month combined exercise program on CTRP-3 and CTRP-5 levels in 76 obese women. The exercise program consisted of 45 min of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (300 kcal/session) and 20 min of resistance training (100 kcal/session) five times per week. Results-Both CTRP-3 and CTRP-5 concentrations were significantly higher in women (P , 0.001) than in men (P = 0.030). In a multiple stepwise regression analysis, CTRP-3 levels were independently associated with age, sex, and triglyceride, LDL cholesterol, adiponectin, and retinol-binding protein 4 (RBP4) levels (R2 = 0.182). After 3 months of a combined exercise program, cardiometabolic risk factors, including components of metabolic syndrome, insulin resistance, and RBP4 levels, decreased significantly. In particular, CTRP-3 levels decreased significantly (median [interquartile range] 444.3 [373.8-535.0] to 374.4 [297.2-435.9], P < 0.001), whereas CTRP-5 levels were slightly increased (34.1 [28.6-44.3] to 38.4 [29.8-55.1], P = 0.048). Conclusions-A 3-month combined exercise program significantly decreased CTRP-3 levels and modestly increased CTRP-5 levels in obese Korean women.

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