Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats

Jong Gun Kim; Eungsuk Lee; Sae Hun Kim; Kwang Youn Whang; Sejong Oh; Jee Young Imm

doi:10.1016/j.idairyj.2009.06.009

Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats

Jong Gun Kim, Eungsuk Lee, Sae Hun Kim, Kwang Youn Whang, Sejong Oh, Jee Young Imm

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19 Citations (Scopus)

Abstract

The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL^-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL^-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.

Original language	English
Pages (from-to)	690-695
Number of pages	6
Journal	International Dairy Journal
Volume	19
Issue number	11
DOIs	https://doi.org/10.1016/j.idairyj.2009.06.009
Publication status	Published - 2009 Nov 1

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ASJC Scopus subject areas

Food Science
Applied Microbiology and Biotechnology

Cite this

Kim, J. G., Lee, E., Kim, S. H., Whang, K. Y., Oh, S., & Imm, J. Y. (2009). Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats. International Dairy Journal, 19(11), 690-695. https://doi.org/10.1016/j.idairyj.2009.06.009

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abstract = "The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.",

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10.1016/j.idairyj.2009.06.009