Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats

Jong Gun Kim; Eungsuk Lee; Sae Hun Kim; Kwang Youn Whang; Sejong Oh; Jee Young Imm

doi:10.1016/j.idairyj.2009.06.009

Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats

Jong Gun Kim, Eungsuk Lee, Sae Hun Kim, Kwang Youn Whang, Sejong Oh, Jee Young Imm

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL^-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL^-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.

Original language	English
Pages (from-to)	690-695
Number of pages	6
Journal	International Dairy Journal
Volume	19
Issue number	11
DOIs	https://doi.org/10.1016/j.idairyj.2009.06.009
Publication status	Published - 2009 Nov

ASJC Scopus subject areas

Food Science
Applied Microbiology and Biotechnology

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10.1016/j.idairyj.2009.06.009

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@article{d90856bbcb2f4a67bfa8df77ecd6acf6,

title = "Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats",

abstract = "The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.",

author = "Kim, {Jong Gun} and Eungsuk Lee and Kim, {Sae Hun} and Whang, {Kwang Youn} and Sejong Oh and Imm, {Jee Young}",

note = "Funding Information: This work was supported by a grant program of the Agricultural Research Promotion Center, Ministry of Agriculture and Forestry, Korea, and by Samik Dairy & Food Co., Ltd. This work was also supported by a grant from Kookmin University received in 2007. The authors are thankful for the financial support.",

year = "2009",

month = nov,

doi = "10.1016/j.idairyj.2009.06.009",

language = "English",

volume = "19",

pages = "690--695",

journal = "International Dairy Journal",

issn = "0958-6946",

publisher = "Elsevier BV",

number = "11",

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T1 - Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats

AU - Kim, Jong Gun

AU - Lee, Eungsuk

AU - Kim, Sae Hun

AU - Whang, Kwang Youn

AU - Oh, Sejong

AU - Imm, Jee Young

N1 - Funding Information: This work was supported by a grant program of the Agricultural Research Promotion Center, Ministry of Agriculture and Forestry, Korea, and by Samik Dairy & Food Co., Ltd. This work was also supported by a grant from Kookmin University received in 2007. The authors are thankful for the financial support.

PY - 2009/11

Y1 - 2009/11

N2 - The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.

AB - The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.

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U2 - 10.1016/j.idairyj.2009.06.009

DO - 10.1016/j.idairyj.2009.06.009

M3 - Article

AN - SCOPUS:69349087186

VL - 19

SP - 690

EP - 695

JO - International Dairy Journal

JF - International Dairy Journal

SN - 0958-6946

IS - 11

ER -

Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats

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ASJC Scopus subject areas

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