Abstract
The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.
| Original language | English |
|---|---|
| Pages (from-to) | 690-695 |
| Number of pages | 6 |
| Journal | International Dairy Journal |
| Volume | 19 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2009 Nov 1 |
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ASJC Scopus subject areas
- Food Science
- Applied Microbiology and Biotechnology
Cite this
Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats. / Kim, Jong Gun; Lee, Eungsuk; Kim, Sae Hun; Whang, Kwang Youn; Oh, Sejong; Imm, Jee Young.
In: International Dairy Journal, Vol. 19, No. 11, 01.11.2009, p. 690-695.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats
AU - Kim, Jong Gun
AU - Lee, Eungsuk
AU - Kim, Sae Hun
AU - Whang, Kwang Youn
AU - Oh, Sejong
AU - Imm, Jee Young
PY - 2009/11/1
Y1 - 2009/11/1
N2 - The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.
AB - The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.
UR - http://www.scopus.com/inward/record.url?scp=69349087186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69349087186&partnerID=8YFLogxK
U2 - 10.1016/j.idairyj.2009.06.009
DO - 10.1016/j.idairyj.2009.06.009
M3 - Article
AN - SCOPUS:69349087186
VL - 19
SP - 690
EP - 695
JO - International Dairy Journal
JF - International Dairy Journal
SN - 0958-6946
IS - 11
ER -