Abstract
The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.
| Original language | English |
|---|---|
| Pages (from-to) | 690-695 |
| Number of pages | 6 |
| Journal | International Dairy Journal |
| Volume | 19 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2009 Nov |
ASJC Scopus subject areas
- Food Science
- Applied Microbiology and Biotechnology
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Cite this
Kim, J. G., Lee, E., Kim, S. H., Whang, K. Y., Oh, S., & Imm, J. Y. (2009). Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats. International Dairy Journal, 19(11), 690-695. https://doi.org/10.1016/j.idairyj.2009.06.009