TY - JOUR
T1 - Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats
AU - Kim, Jong Gun
AU - Lee, Eungsuk
AU - Kim, Sae Hun
AU - Whang, Kwang Youn
AU - Oh, Sejong
AU - Imm, Jee Young
N1 - Funding Information:
This work was supported by a grant program of the Agricultural Research Promotion Center, Ministry of Agriculture and Forestry, Korea, and by Samik Dairy & Food Co., Ltd. This work was also supported by a grant from Kookmin University received in 2007. The authors are thankful for the financial support.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/11
Y1 - 2009/11
N2 - The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.
AB - The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL-1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL-1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.
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U2 - 10.1016/j.idairyj.2009.06.009
DO - 10.1016/j.idairyj.2009.06.009
M3 - Article
AN - SCOPUS:69349087186
VL - 19
SP - 690
EP - 695
JO - International Dairy Journal
JF - International Dairy Journal
SN - 0958-6946
IS - 11
ER -