Effects of a three-month combined exercise programme on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women

Sae Jeong Yang, Ho Cheol Hong, Hae Yoon Choi, Hye-Jin Yoo, Geum-Joon Cho, Teak Geun Hwang, Sei-Hyun Baik, Dong Seop Choi, Seon Mee Kim, Kyung Mook Choi

Research output: Contribution to journalArticle

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Abstract

Objective We examined the relationship between brachial-ankle pulse wave velocity (baPWV) reflecting arterial stiffness and the levels of novel hepatokines fibroblast growth factor 21 (FGF21) and fetuin-A. In addition, we evaluated the effect of a 3-month combined aerobic and resistance exercise programme on FGF21 and fetuin-A levels as well as arterial stiffness in obese women. Methods Forty nondiabetic, obese women (body mass index = 27 ·6 ± 2 ·4 kg/m 2) were included in the study and were compared before and after a 3-month exercise programme, which was composed of 45 min of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (300 kcal/session) and 20 min of resistance training (100 kcal/session) five times a week. All exercise sessions were supervised by a professional exercise physiologist. Results At baseline, baPWV levels were correlated with age, body mass index (BMI), systolic blood pressure (SBP), high density lipoprotein cholesterol, fasting glucose and serum FGF21 levels. In a multiple stepwise regression analysis using baPWV as a dependent variable, baPWV levels were associated with age, BMI, SBP, FGF21 and fetuin-A levels (R 2 = 0 ·744). After the exercise programme, BMI, waist circumference, SBP, diastolic blood pressure and triglyceride levels were significantly decreased. Moreover, baPWV values were significantly improved (P < 0 ·001) along with modest decrease in FGF21 levels (P = 0 ·043). However, fetuin-A levels were not changed significantly (P = 0 ·202). Conclusions A 3-month combined exercise programme decreases the FGF21 levels as well as arterial stiffness in obese Korean women.

Original languageEnglish
Pages (from-to)464-469
Number of pages6
JournalClinical Endocrinology
Volume75
Issue number4
DOIs
Publication statusPublished - 2011 Oct 1

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alpha-2-HS-Glycoprotein
Vascular Stiffness
Pulse Wave Analysis
Exercise
Blood Pressure
Ankle
Arm
Body Mass Index
Resistance Training
fibroblast growth factor 21
Waist Circumference
HDL Cholesterol
Fasting
Triglycerides
Heart Rate
Regression Analysis
Glucose

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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Effects of a three-month combined exercise programme on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women. / Yang, Sae Jeong; Hong, Ho Cheol; Choi, Hae Yoon; Yoo, Hye-Jin; Cho, Geum-Joon; Hwang, Teak Geun; Baik, Sei-Hyun; Choi, Dong Seop; Kim, Seon Mee; Choi, Kyung Mook.

In: Clinical Endocrinology, Vol. 75, No. 4, 01.10.2011, p. 464-469.

Research output: Contribution to journalArticle

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abstract = "Objective We examined the relationship between brachial-ankle pulse wave velocity (baPWV) reflecting arterial stiffness and the levels of novel hepatokines fibroblast growth factor 21 (FGF21) and fetuin-A. In addition, we evaluated the effect of a 3-month combined aerobic and resistance exercise programme on FGF21 and fetuin-A levels as well as arterial stiffness in obese women. Methods Forty nondiabetic, obese women (body mass index = 27 ·6 ± 2 ·4 kg/m 2) were included in the study and were compared before and after a 3-month exercise programme, which was composed of 45 min of aerobic exercise at an intensity of 60-75{\%} of the age-predicted maximum heart rate (300 kcal/session) and 20 min of resistance training (100 kcal/session) five times a week. All exercise sessions were supervised by a professional exercise physiologist. Results At baseline, baPWV levels were correlated with age, body mass index (BMI), systolic blood pressure (SBP), high density lipoprotein cholesterol, fasting glucose and serum FGF21 levels. In a multiple stepwise regression analysis using baPWV as a dependent variable, baPWV levels were associated with age, BMI, SBP, FGF21 and fetuin-A levels (R 2 = 0 ·744). After the exercise programme, BMI, waist circumference, SBP, diastolic blood pressure and triglyceride levels were significantly decreased. Moreover, baPWV values were significantly improved (P < 0 ·001) along with modest decrease in FGF21 levels (P = 0 ·043). However, fetuin-A levels were not changed significantly (P = 0 ·202). Conclusions A 3-month combined exercise programme decreases the FGF21 levels as well as arterial stiffness in obese Korean women.",
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T1 - Effects of a three-month combined exercise programme on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women

AU - Yang, Sae Jeong

AU - Hong, Ho Cheol

AU - Choi, Hae Yoon

AU - Yoo, Hye-Jin

AU - Cho, Geum-Joon

AU - Hwang, Teak Geun

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Kim, Seon Mee

AU - Choi, Kyung Mook

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N2 - Objective We examined the relationship between brachial-ankle pulse wave velocity (baPWV) reflecting arterial stiffness and the levels of novel hepatokines fibroblast growth factor 21 (FGF21) and fetuin-A. In addition, we evaluated the effect of a 3-month combined aerobic and resistance exercise programme on FGF21 and fetuin-A levels as well as arterial stiffness in obese women. Methods Forty nondiabetic, obese women (body mass index = 27 ·6 ± 2 ·4 kg/m 2) were included in the study and were compared before and after a 3-month exercise programme, which was composed of 45 min of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (300 kcal/session) and 20 min of resistance training (100 kcal/session) five times a week. All exercise sessions were supervised by a professional exercise physiologist. Results At baseline, baPWV levels were correlated with age, body mass index (BMI), systolic blood pressure (SBP), high density lipoprotein cholesterol, fasting glucose and serum FGF21 levels. In a multiple stepwise regression analysis using baPWV as a dependent variable, baPWV levels were associated with age, BMI, SBP, FGF21 and fetuin-A levels (R 2 = 0 ·744). After the exercise programme, BMI, waist circumference, SBP, diastolic blood pressure and triglyceride levels were significantly decreased. Moreover, baPWV values were significantly improved (P < 0 ·001) along with modest decrease in FGF21 levels (P = 0 ·043). However, fetuin-A levels were not changed significantly (P = 0 ·202). Conclusions A 3-month combined exercise programme decreases the FGF21 levels as well as arterial stiffness in obese Korean women.

AB - Objective We examined the relationship between brachial-ankle pulse wave velocity (baPWV) reflecting arterial stiffness and the levels of novel hepatokines fibroblast growth factor 21 (FGF21) and fetuin-A. In addition, we evaluated the effect of a 3-month combined aerobic and resistance exercise programme on FGF21 and fetuin-A levels as well as arterial stiffness in obese women. Methods Forty nondiabetic, obese women (body mass index = 27 ·6 ± 2 ·4 kg/m 2) were included in the study and were compared before and after a 3-month exercise programme, which was composed of 45 min of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (300 kcal/session) and 20 min of resistance training (100 kcal/session) five times a week. All exercise sessions were supervised by a professional exercise physiologist. Results At baseline, baPWV levels were correlated with age, body mass index (BMI), systolic blood pressure (SBP), high density lipoprotein cholesterol, fasting glucose and serum FGF21 levels. In a multiple stepwise regression analysis using baPWV as a dependent variable, baPWV levels were associated with age, BMI, SBP, FGF21 and fetuin-A levels (R 2 = 0 ·744). After the exercise programme, BMI, waist circumference, SBP, diastolic blood pressure and triglyceride levels were significantly decreased. Moreover, baPWV values were significantly improved (P < 0 ·001) along with modest decrease in FGF21 levels (P = 0 ·043). However, fetuin-A levels were not changed significantly (P = 0 ·202). Conclusions A 3-month combined exercise programme decreases the FGF21 levels as well as arterial stiffness in obese Korean women.

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