Abstract
Ethanol has various effects on male sexual activity under the influence of direct and indirect, in acute and chronic alcohol ingestion. However, whether acetaldehyde, a principal metabolite of ethanol, may affect penile erection directly has still not been elucidated. This present study was, therefore, designed to clarify the pharmacologic effects of the acetaldehyde on corpus cavernosal smooth muscle. Corpus cavernosal strips were prepared from rabbit penises. Isometric tension changes of rabbit corpus cavernosal strips to various drugs and electrical field stimulation (EFS) in an organ chamber were recorded with a pressure transducer after active muscle tone had been induced by phenylephrine (10-5 mol/L). At the concentrations employed, acetaldehyde had no effect on the pH of the bathing medium. Acetaldehyde in each concentration did not significantly affect resting tone of the smooth muscle during 30 min incubation. Acetaldehyde suppressed contractility induced by phenylephrine and KCI at 10-4 mol/L, and relaxation induced by EFS and bethanechol at 10-3 mol/L and 10-4 mol/L respectively, but acetaldehyde enhanced relaxation induced by ATP at high acetaldehyde level. Sodium nitroprusside-induced relaxation was not affected at any employed acetaldehyde concentration. This suggests that increasing the acetaldehyde level may contribute to male erectile dysfunction mainly by the inhibition of nitric oxide formation.
| Original language | English |
|---|---|
| Pages (from-to) | 295-298 |
| Number of pages | 4 |
| Journal | Journal of Korean Medical Science |
| Volume | 15 |
| Issue number | 3 |
| Publication status | Published - 2000 Jun 1 |
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Keywords
- Acetaldehyde
- Corpus Cavernosum
- Muscle, Smooth
ASJC Scopus subject areas
- Medicine(all)
Cite this
Effects of acetaldehyde on responses of rabbit corpus cavernosal smooth muscle. / Kim, Hyung Jee; Sohng, Inho; Lee, Gilho; Kim, Je-Jong; Koh, Sung Kun.
In: Journal of Korean Medical Science, Vol. 15, No. 3, 01.06.2000, p. 295-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of acetaldehyde on responses of rabbit corpus cavernosal smooth muscle
AU - Kim, Hyung Jee
AU - Sohng, Inho
AU - Lee, Gilho
AU - Kim, Je-Jong
AU - Koh, Sung Kun
PY - 2000/6/1
Y1 - 2000/6/1
N2 - Ethanol has various effects on male sexual activity under the influence of direct and indirect, in acute and chronic alcohol ingestion. However, whether acetaldehyde, a principal metabolite of ethanol, may affect penile erection directly has still not been elucidated. This present study was, therefore, designed to clarify the pharmacologic effects of the acetaldehyde on corpus cavernosal smooth muscle. Corpus cavernosal strips were prepared from rabbit penises. Isometric tension changes of rabbit corpus cavernosal strips to various drugs and electrical field stimulation (EFS) in an organ chamber were recorded with a pressure transducer after active muscle tone had been induced by phenylephrine (10-5 mol/L). At the concentrations employed, acetaldehyde had no effect on the pH of the bathing medium. Acetaldehyde in each concentration did not significantly affect resting tone of the smooth muscle during 30 min incubation. Acetaldehyde suppressed contractility induced by phenylephrine and KCI at 10-4 mol/L, and relaxation induced by EFS and bethanechol at 10-3 mol/L and 10-4 mol/L respectively, but acetaldehyde enhanced relaxation induced by ATP at high acetaldehyde level. Sodium nitroprusside-induced relaxation was not affected at any employed acetaldehyde concentration. This suggests that increasing the acetaldehyde level may contribute to male erectile dysfunction mainly by the inhibition of nitric oxide formation.
AB - Ethanol has various effects on male sexual activity under the influence of direct and indirect, in acute and chronic alcohol ingestion. However, whether acetaldehyde, a principal metabolite of ethanol, may affect penile erection directly has still not been elucidated. This present study was, therefore, designed to clarify the pharmacologic effects of the acetaldehyde on corpus cavernosal smooth muscle. Corpus cavernosal strips were prepared from rabbit penises. Isometric tension changes of rabbit corpus cavernosal strips to various drugs and electrical field stimulation (EFS) in an organ chamber were recorded with a pressure transducer after active muscle tone had been induced by phenylephrine (10-5 mol/L). At the concentrations employed, acetaldehyde had no effect on the pH of the bathing medium. Acetaldehyde in each concentration did not significantly affect resting tone of the smooth muscle during 30 min incubation. Acetaldehyde suppressed contractility induced by phenylephrine and KCI at 10-4 mol/L, and relaxation induced by EFS and bethanechol at 10-3 mol/L and 10-4 mol/L respectively, but acetaldehyde enhanced relaxation induced by ATP at high acetaldehyde level. Sodium nitroprusside-induced relaxation was not affected at any employed acetaldehyde concentration. This suggests that increasing the acetaldehyde level may contribute to male erectile dysfunction mainly by the inhibition of nitric oxide formation.
KW - Acetaldehyde
KW - Corpus Cavernosum
KW - Muscle, Smooth
UR - http://www.scopus.com/inward/record.url?scp=0034203278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034203278&partnerID=8YFLogxK
M3 - Article
C2 - 10895971
AN - SCOPUS:0034203278
VL - 15
SP - 295
EP - 298
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 3
ER -