Effects of alcohol hangover on cytokine production in healthy subjects

Dai Jin Kim, Won Kim, Su Jung Yoon, Bo Moon Choi, Jung Soo Kim, Hyo Jin Go, Yong Ku Kim, Jaeseung Jeong

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A hangover is the syndrome of physical and mental symptoms that occurs 8 to 16 h after alcohol consumption with a zero level of alcohol. The aim of the current study was to investigate the effects of the alcohol hangover on cytokine production in healthy subjects. The hangover state was defined as 13 h after drinking 1.5 g/kg of alcohol (blood alcohol level=0). A venous blood sample was taken from 20 healthy adult men before consumption of alcohol and during the hangover state. Peripheral blood mononuclear cells were separated and stimulated with phytohemagglutinin. An enzyme-linked immunosorbent assay was used to measure the production of the following cytokines: interleukin (IL)-1β, IL-4, IL-6, IL-10, IL-12, interferon-gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α). We found that the concentrations of IL-10, IL-12, and IFN-γ were significantly increased during the hangover state compared with the concentrations in normal conditions. These results support the suggestion that the dysregulated cytokine pathway (IL-10, IL-12, and IFN-γ) is associated with the symptoms of hangovers.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalAlcohol
Volume31
Issue number3
DOIs
Publication statusPublished - 2003 Jan 1

Fingerprint

Interleukin-12
Interleukin-10
Interferon-gamma
Healthy Volunteers
alcohol
Alcohols
Cytokines
Alcohol Drinking
Blood
Phytohemagglutinins
Interleukin-1
Interleukin-4
Drinking
Interleukin-6
Blood Cells
Tumor Necrosis Factor-alpha
Enzyme-Linked Immunosorbent Assay
Immunosorbents
alcohol consumption
Assays

Keywords

  • Alcohol
  • Cytokine
  • Hangover

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

Cite this

Kim, D. J., Kim, W., Yoon, S. J., Choi, B. M., Kim, J. S., Go, H. J., ... Jeong, J. (2003). Effects of alcohol hangover on cytokine production in healthy subjects. Alcohol, 31(3), 167-170. https://doi.org/10.1016/j.alcohol.2003.09.003

Effects of alcohol hangover on cytokine production in healthy subjects. / Kim, Dai Jin; Kim, Won; Yoon, Su Jung; Choi, Bo Moon; Kim, Jung Soo; Go, Hyo Jin; Kim, Yong Ku; Jeong, Jaeseung.

In: Alcohol, Vol. 31, No. 3, 01.01.2003, p. 167-170.

Research output: Contribution to journalArticle

Kim, DJ, Kim, W, Yoon, SJ, Choi, BM, Kim, JS, Go, HJ, Kim, YK & Jeong, J 2003, 'Effects of alcohol hangover on cytokine production in healthy subjects', Alcohol, vol. 31, no. 3, pp. 167-170. https://doi.org/10.1016/j.alcohol.2003.09.003
Kim DJ, Kim W, Yoon SJ, Choi BM, Kim JS, Go HJ et al. Effects of alcohol hangover on cytokine production in healthy subjects. Alcohol. 2003 Jan 1;31(3):167-170. https://doi.org/10.1016/j.alcohol.2003.09.003
Kim, Dai Jin ; Kim, Won ; Yoon, Su Jung ; Choi, Bo Moon ; Kim, Jung Soo ; Go, Hyo Jin ; Kim, Yong Ku ; Jeong, Jaeseung. / Effects of alcohol hangover on cytokine production in healthy subjects. In: Alcohol. 2003 ; Vol. 31, No. 3. pp. 167-170.
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