Effects of anodized implants coated with Escherichia coli-derived rhBMP-2 in beagle dogs

Jung Bo Huh, Sung Eun Kim, Hyo Eon Kim, Seong Soo Kang, Kyung Hee Choi, Chang Mo Jeong, Jeong Yol Lee, Sang Wan Shin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

This study evaluated the effects of Escherichia coli-derived rhBMP-2 (ErhBMP-2) coated onto anodized implants to stimulate bone formation, osseointegration and vertical bone growth in a vertical bone defect model. Six young adult beagle dogs were used. After a 2-month bone healing period, anodized titanium implants (8 mm in length) were placed 5.5 mm into the mandibular alveolar ridge. Eighteen implants coated with ErhBMP-2 (BMP group) and another 18 uncoated implants (control group) were installed using a randomized split-mouth design. The implant stability quotient (ISQ) values were measured. Specimens were fabricated for histometric analysis to evaluate osseointegration and bone formation. The ISQ values at 8 weeks after implant placement were significantly higher in the BMP group than in the control group (p < 0.05). Histological observations showed that the changes in bucco-lingual alveolar bone levels were higher in the BMP group than in the control group (p < 0.05). The ErhBMP-2 coated anodized implants can stimulate bone formation and increase implant stability significantly on completely healed alveolar ridges in dogs. Further studies evaluating the effects of ErhBMP-2 on osseointegration in the bone-implant interface are warranted.

Original languageEnglish
Pages (from-to)1577-1584
Number of pages8
JournalInternational Journal of Oral and Maxillofacial Surgery
Volume41
Issue number12
DOIs
Publication statusPublished - 2012 Dec 1

Keywords

  • anodized implant
  • bone growth
  • coating
  • osseointegration
  • rhBMP-2

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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