Effects of anodized implants coated with Escherichia coli-derived rhBMP-2 in beagle dogs

Jung Bo Huh; Sung Eun Kim; Hyo Eon Kim; Seong Soo Kang; Kyung Hee Choi; Chang Mo Jeong; Jeong Yol Lee; Sang Wan Shin

doi:10.1016/j.ijom.2012.04.005

Effects of anodized implants coated with Escherichia coli-derived rhBMP-2 in beagle dogs

Jung Bo Huh, Sung Eun Kim, Hyo Eon Kim, Seong Soo Kang, Kyung Hee Choi, Chang Mo Jeong, Jeong Yol Lee, Sang Wan Shin

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

This study evaluated the effects of Escherichia coli-derived rhBMP-2 (ErhBMP-2) coated onto anodized implants to stimulate bone formation, osseointegration and vertical bone growth in a vertical bone defect model. Six young adult beagle dogs were used. After a 2-month bone healing period, anodized titanium implants (8 mm in length) were placed 5.5 mm into the mandibular alveolar ridge. Eighteen implants coated with ErhBMP-2 (BMP group) and another 18 uncoated implants (control group) were installed using a randomized split-mouth design. The implant stability quotient (ISQ) values were measured. Specimens were fabricated for histometric analysis to evaluate osseointegration and bone formation. The ISQ values at 8 weeks after implant placement were significantly higher in the BMP group than in the control group (p < 0.05). Histological observations showed that the changes in bucco-lingual alveolar bone levels were higher in the BMP group than in the control group (p < 0.05). The ErhBMP-2 coated anodized implants can stimulate bone formation and increase implant stability significantly on completely healed alveolar ridges in dogs. Further studies evaluating the effects of ErhBMP-2 on osseointegration in the bone-implant interface are warranted.

Original language	English
Pages (from-to)	1577-1584
Number of pages	8
Journal	International Journal of Oral and Maxillofacial Surgery
Volume	41
Issue number	12
DOIs	https://doi.org/10.1016/j.ijom.2012.04.005
Publication status	Published - 2012 Dec

Keywords

anodized implant
bone growth
coating
osseointegration
rhBMP-2

ASJC Scopus subject areas

Surgery
Oral Surgery
Otorhinolaryngology

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10.1016/j.ijom.2012.04.005

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title = "Effects of anodized implants coated with Escherichia coli-derived rhBMP-2 in beagle dogs",

abstract = "This study evaluated the effects of Escherichia coli-derived rhBMP-2 (ErhBMP-2) coated onto anodized implants to stimulate bone formation, osseointegration and vertical bone growth in a vertical bone defect model. Six young adult beagle dogs were used. After a 2-month bone healing period, anodized titanium implants (8 mm in length) were placed 5.5 mm into the mandibular alveolar ridge. Eighteen implants coated with ErhBMP-2 (BMP group) and another 18 uncoated implants (control group) were installed using a randomized split-mouth design. The implant stability quotient (ISQ) values were measured. Specimens were fabricated for histometric analysis to evaluate osseointegration and bone formation. The ISQ values at 8 weeks after implant placement were significantly higher in the BMP group than in the control group (p < 0.05). Histological observations showed that the changes in bucco-lingual alveolar bone levels were higher in the BMP group than in the control group (p < 0.05). The ErhBMP-2 coated anodized implants can stimulate bone formation and increase implant stability significantly on completely healed alveolar ridges in dogs. Further studies evaluating the effects of ErhBMP-2 on osseointegration in the bone-implant interface are warranted.",

keywords = "anodized implant, bone growth, coating, osseointegration, rhBMP-2",

author = "Huh, {Jung Bo} and Kim, {Sung Eun} and Kim, {Hyo Eon} and Kang, {Seong Soo} and Choi, {Kyung Hee} and Jeong, {Chang Mo} and Lee, {Jeong Yol} and Shin, {Sang Wan}",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology (2012005122). ",

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AU - Huh, Jung Bo

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AU - Kang, Seong Soo

AU - Choi, Kyung Hee

AU - Jeong, Chang Mo

AU - Lee, Jeong Yol

AU - Shin, Sang Wan

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology (2012005122).

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N2 - This study evaluated the effects of Escherichia coli-derived rhBMP-2 (ErhBMP-2) coated onto anodized implants to stimulate bone formation, osseointegration and vertical bone growth in a vertical bone defect model. Six young adult beagle dogs were used. After a 2-month bone healing period, anodized titanium implants (8 mm in length) were placed 5.5 mm into the mandibular alveolar ridge. Eighteen implants coated with ErhBMP-2 (BMP group) and another 18 uncoated implants (control group) were installed using a randomized split-mouth design. The implant stability quotient (ISQ) values were measured. Specimens were fabricated for histometric analysis to evaluate osseointegration and bone formation. The ISQ values at 8 weeks after implant placement were significantly higher in the BMP group than in the control group (p < 0.05). Histological observations showed that the changes in bucco-lingual alveolar bone levels were higher in the BMP group than in the control group (p < 0.05). The ErhBMP-2 coated anodized implants can stimulate bone formation and increase implant stability significantly on completely healed alveolar ridges in dogs. Further studies evaluating the effects of ErhBMP-2 on osseointegration in the bone-implant interface are warranted.

AB - This study evaluated the effects of Escherichia coli-derived rhBMP-2 (ErhBMP-2) coated onto anodized implants to stimulate bone formation, osseointegration and vertical bone growth in a vertical bone defect model. Six young adult beagle dogs were used. After a 2-month bone healing period, anodized titanium implants (8 mm in length) were placed 5.5 mm into the mandibular alveolar ridge. Eighteen implants coated with ErhBMP-2 (BMP group) and another 18 uncoated implants (control group) were installed using a randomized split-mouth design. The implant stability quotient (ISQ) values were measured. Specimens were fabricated for histometric analysis to evaluate osseointegration and bone formation. The ISQ values at 8 weeks after implant placement were significantly higher in the BMP group than in the control group (p < 0.05). Histological observations showed that the changes in bucco-lingual alveolar bone levels were higher in the BMP group than in the control group (p < 0.05). The ErhBMP-2 coated anodized implants can stimulate bone formation and increase implant stability significantly on completely healed alveolar ridges in dogs. Further studies evaluating the effects of ErhBMP-2 on osseointegration in the bone-implant interface are warranted.

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Effects of anodized implants coated with Escherichia coli-derived rhBMP-2 in beagle dogs

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