Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells

Seok Keun Choi, Young Sam Park, Dong Kug Choi, Hyo Ihl Chang

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Astaxanthin has shown antioxidant, antitumor, and anti-inflammatory activities; however, its molecular action and mechanism in the nervous system have yet to be elucidated. We examined the in vitro effects of astaxanthin on the production of nitric oxide (NO), as well as the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Astaxanthin inhibited the expression or formation of nitric oxide (NO), iNOS and COX-2 in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Astaxanthin also suppressed the protein levels of iNOS and COX-2 in LPS-stimulated BV2 microglial cells. These results suggest that astaxanthin, probably due to its antioxidant activity, inhibits the production of inflammatory mediators by blocking iNOS and COX-2 activation or by the suppression of iNOS and COX-2 degradation.

Original languageEnglish
Pages (from-to)1990-1996
Number of pages7
JournalJournal of microbiology and biotechnology
Volume18
Issue number12
DOIs
Publication statusPublished - 2008 Dec 28

Keywords

  • Anti-inflammatory activity
  • Astaxanthin
  • BV2 microglial cell
  • Inflammatory mediator

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

Fingerprint Dive into the research topics of 'Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells'. Together they form a unique fingerprint.

  • Cite this