Effects of atypical antipsychotic drugs on body weight and food intake in dopamine D2 receptor knockout mice

Sehyoun Yoon, Jai Sung Noh, Se Young Choi, Ja-Hyun Baik

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Many atypical antipsychotic drugs cause weight gain, but the mechanism of this weight gain is unclear. To dissect the role of the dopamine D2 receptor (D2R), an important receptor in the pharmacology of antipsychotic drugs, we analyzed the effect of olanzapine, risperidone, and ziprasidone on changes in body weight and food intake in male wild-type (WT) and D2R knockout (D2R-/-) mice. The oral delivery of atypical antipsychotics, olanzapine (5 and 10 mg/kg), risperidone (0.1 and 1.0 mg/kg) and ziprasidone (10 and 20 mg/kg) in both strains mice for 2 weeks suppressed body weight gain, except for olanzapine treatment in D2R-/- mice. Olanzapine treatment suppressed body weight gain and decreased food intake in WT mice, but also reduced fat body mass and locomotor activity, whereas D2R-/- mice did not show these changes. Ziprasidone and risperidone treatment produced similar responses in WT and D2R-/- mice. These data suggest the involvement of D2R in the effect of olanzapine on metabolic regulation. Further studies are required to explore the implications of D2R activity in antipsychotic-mediated metabolic complications.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume393
Issue number2
DOIs
Publication statusPublished - 2010 Mar 5

Fingerprint

olanzapine
Dopamine D2 Receptors
Knockout Mice
Antipsychotic Agents
Eating
Body Weight
Risperidone
Weight Gain
Body Weight Changes
Fat Body
Locomotion
Fats
Pharmacology

Keywords

  • Atypical antipsychotic drugs
  • Body weight gain
  • Dopamine D2 receptor
  • Olanzapine
  • Risperidone
  • Schizophrenia
  • Ziprasidone

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Effects of atypical antipsychotic drugs on body weight and food intake in dopamine D2 receptor knockout mice. / Yoon, Sehyoun; Noh, Jai Sung; Choi, Se Young; Baik, Ja-Hyun.

In: Biochemical and Biophysical Research Communications, Vol. 393, No. 2, 05.03.2010, p. 235-241.

Research output: Contribution to journalArticle

@article{baa58be985e941b59be9c2b7c309d7f0,
title = "Effects of atypical antipsychotic drugs on body weight and food intake in dopamine D2 receptor knockout mice",
abstract = "Many atypical antipsychotic drugs cause weight gain, but the mechanism of this weight gain is unclear. To dissect the role of the dopamine D2 receptor (D2R), an important receptor in the pharmacology of antipsychotic drugs, we analyzed the effect of olanzapine, risperidone, and ziprasidone on changes in body weight and food intake in male wild-type (WT) and D2R knockout (D2R-/-) mice. The oral delivery of atypical antipsychotics, olanzapine (5 and 10 mg/kg), risperidone (0.1 and 1.0 mg/kg) and ziprasidone (10 and 20 mg/kg) in both strains mice for 2 weeks suppressed body weight gain, except for olanzapine treatment in D2R-/- mice. Olanzapine treatment suppressed body weight gain and decreased food intake in WT mice, but also reduced fat body mass and locomotor activity, whereas D2R-/- mice did not show these changes. Ziprasidone and risperidone treatment produced similar responses in WT and D2R-/- mice. These data suggest the involvement of D2R in the effect of olanzapine on metabolic regulation. Further studies are required to explore the implications of D2R activity in antipsychotic-mediated metabolic complications.",
keywords = "Atypical antipsychotic drugs, Body weight gain, Dopamine D2 receptor, Olanzapine, Risperidone, Schizophrenia, Ziprasidone",
author = "Sehyoun Yoon and Noh, {Jai Sung} and Choi, {Se Young} and Ja-Hyun Baik",
year = "2010",
month = "3",
day = "5",
doi = "10.1016/j.bbrc.2010.01.108",
language = "English",
volume = "393",
pages = "235--241",
journal = "The BMJ",
issn = "0730-6512",
publisher = "Kluwer Academic Publishers",
number = "2",

}

TY - JOUR

T1 - Effects of atypical antipsychotic drugs on body weight and food intake in dopamine D2 receptor knockout mice

AU - Yoon, Sehyoun

AU - Noh, Jai Sung

AU - Choi, Se Young

AU - Baik, Ja-Hyun

PY - 2010/3/5

Y1 - 2010/3/5

N2 - Many atypical antipsychotic drugs cause weight gain, but the mechanism of this weight gain is unclear. To dissect the role of the dopamine D2 receptor (D2R), an important receptor in the pharmacology of antipsychotic drugs, we analyzed the effect of olanzapine, risperidone, and ziprasidone on changes in body weight and food intake in male wild-type (WT) and D2R knockout (D2R-/-) mice. The oral delivery of atypical antipsychotics, olanzapine (5 and 10 mg/kg), risperidone (0.1 and 1.0 mg/kg) and ziprasidone (10 and 20 mg/kg) in both strains mice for 2 weeks suppressed body weight gain, except for olanzapine treatment in D2R-/- mice. Olanzapine treatment suppressed body weight gain and decreased food intake in WT mice, but also reduced fat body mass and locomotor activity, whereas D2R-/- mice did not show these changes. Ziprasidone and risperidone treatment produced similar responses in WT and D2R-/- mice. These data suggest the involvement of D2R in the effect of olanzapine on metabolic regulation. Further studies are required to explore the implications of D2R activity in antipsychotic-mediated metabolic complications.

AB - Many atypical antipsychotic drugs cause weight gain, but the mechanism of this weight gain is unclear. To dissect the role of the dopamine D2 receptor (D2R), an important receptor in the pharmacology of antipsychotic drugs, we analyzed the effect of olanzapine, risperidone, and ziprasidone on changes in body weight and food intake in male wild-type (WT) and D2R knockout (D2R-/-) mice. The oral delivery of atypical antipsychotics, olanzapine (5 and 10 mg/kg), risperidone (0.1 and 1.0 mg/kg) and ziprasidone (10 and 20 mg/kg) in both strains mice for 2 weeks suppressed body weight gain, except for olanzapine treatment in D2R-/- mice. Olanzapine treatment suppressed body weight gain and decreased food intake in WT mice, but also reduced fat body mass and locomotor activity, whereas D2R-/- mice did not show these changes. Ziprasidone and risperidone treatment produced similar responses in WT and D2R-/- mice. These data suggest the involvement of D2R in the effect of olanzapine on metabolic regulation. Further studies are required to explore the implications of D2R activity in antipsychotic-mediated metabolic complications.

KW - Atypical antipsychotic drugs

KW - Body weight gain

KW - Dopamine D2 receptor

KW - Olanzapine

KW - Risperidone

KW - Schizophrenia

KW - Ziprasidone

UR - http://www.scopus.com/inward/record.url?scp=77649338442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649338442&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2010.01.108

DO - 10.1016/j.bbrc.2010.01.108

M3 - Article

VL - 393

SP - 235

EP - 241

JO - The BMJ

JF - The BMJ

SN - 0730-6512

IS - 2

ER -