Effects of black raspberry on lipid profiles and vascular endothelial function in patients with metabolic syndrome

Han Saem Jeong, Soon Jun Hong, Tae Bum Lee, Ji Wung Kwon, Jong Tae Jeong, Hyung Joon Joo, Jae Hyoung Park, Chul Min Ahn, Cheol Woong Yu, Do Sun Lim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Black raspberry (Rubus occidentalis) has been known for its anti-inflammatory and anti-oxidant effects. However, short-term effects of black raspberry on lipid profiles and vascular endothelial function have not been investigated in patients with metabolic syndrome. Patients with metabolic syndrome (n=77) were prospectively randomized into a group with black raspberry (n=39, 750mg/day) and a placebo group (n=38) during a 12-week follow-up. Lipid profiles, brachial artery flow-mediated dilatation (baFMD), and inflammatory cytokines such as IL-6, TNF-α, C-reactive protein, adiponectin, sICAM-1, and sVCAM-1 were measured at the baseline and at the 12-week follow-up. Decreases from the baseline in the total cholesterol level (-22.8±30.4mg/dL vs. -1.9±31.8mg/dL, p<0.05, respectively) and total cholesterol/HDL ratio (-0.31±0.64 vs. 0.07±0.58, p<0.05, respectively) were significantly greater in the group with black raspberry than in the placebo group. Increases in baFMD at the 12-week follow-up were significantly greater in the group with black raspberry than in the placebo group (0.33±0.44mm vs. 0.10±0.35mm, p<0.05, respectively). Decreases from the baseline in IL-6 (-0.4±1.5pg/mL vs. -0.1±1.0pg/mL, p<0.05, respectively) and TNF-α (-2.9±4.7pg/mL vs. 0.1±3.6pg/mL, p<0.05, respectively) were significantly greater in the group with black raspberry. The use of black raspberry significantly decreased serum total cholesterol level and inflammatory cytokines, thereby improving vascular endothelial function in patients with metabolic syndrome during the 12-week follow-up.

Original languageEnglish
Pages (from-to)1492-1498
Number of pages7
JournalPhytotherapy Research
Volume28
Issue number10
DOIs
Publication statusPublished - 2014 Oct 1

Keywords

  • black raspberry
  • endothelial function
  • inflammation
  • lipid
  • metabolic syndrome

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Jeong, H. S., Hong, S. J., Lee, T. B., Kwon, J. W., Jeong, J. T., Joo, H. J., Park, J. H., Ahn, C. M., Yu, C. W., & Lim, D. S. (2014). Effects of black raspberry on lipid profiles and vascular endothelial function in patients with metabolic syndrome. Phytotherapy Research, 28(10), 1492-1498. https://doi.org/10.1002/ptr.5154