Effects of BMP-2 delivery in calcium phosphate bone graft materials with different compositions on bone regeneration

Jin Chul Park, Eun Bin Bae, Se Eun Kim, So Yun Kim, Kyung Hee Choi, Jae Won Choi, Ji Hyeon Bae, Jae Jun Ryu, Jung Bo Huh

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6 Citations (Scopus)

Abstract

This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated using in-vitro and in-vivo tests. New bone area percentages (%) in the BCP/BMP and CPP/BMP groups were significantly greater than in the BCP and CPP groups. At weeks 4 and 8 post-implantation, CPP/BMP showed the most new bone growth. Within the limitations of this study, treatment of BCP and CPP with rhBMP-2 significantly enhanced bone regeneration. CPP was found to be a suitable carrier for rhBMP-2.

Original languageEnglish
Article number954
JournalMaterials
Volume9
Issue number11
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Alloplast
  • Biphasic calcium phosphate
  • Bone substitutes
  • Calcium pyrophosphate
  • RhBMP-2

ASJC Scopus subject areas

  • Materials Science(all)

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  • Cite this

    Park, J. C., Bae, E. B., Kim, S. E., Kim, S. Y., Choi, K. H., Choi, J. W., Bae, J. H., Ryu, J. J., & Huh, J. B. (2016). Effects of BMP-2 delivery in calcium phosphate bone graft materials with different compositions on bone regeneration. Materials, 9(11), [954]. https://doi.org/10.3390/ma9110954