Effects of BMP-2 delivery in calcium phosphate bone graft materials with different compositions on bone regeneration

Jin Chul Park; Eun Bin Bae; Se Eun Kim; So Yun Kim; Kyung Hee Choi; Jae Won Choi; Ji Hyeon Bae; Jae Jun Ryu; Jung Bo Huh

doi:10.3390/ma9110954

Effects of BMP-2 delivery in calcium phosphate bone graft materials with different compositions on bone regeneration

Jin Chul Park, Eun Bin Bae, Se Eun Kim, So Yun Kim, Kyung Hee Choi, Jae Won Choi, Ji Hyeon Bae, Jae Jun Ryu, Jung Bo Huh

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated using in-vitro and in-vivo tests. New bone area percentages (%) in the BCP/BMP and CPP/BMP groups were significantly greater than in the BCP and CPP groups. At weeks 4 and 8 post-implantation, CPP/BMP showed the most new bone growth. Within the limitations of this study, treatment of BCP and CPP with rhBMP-2 significantly enhanced bone regeneration. CPP was found to be a suitable carrier for rhBMP-2.

Original language	English
Article number	954
Journal	Materials
Volume	9
Issue number	11
DOIs	https://doi.org/10.3390/ma9110954
Publication status	Published - 2016
Externally published	Yes

Keywords

Alloplast
Biphasic calcium phosphate
Bone substitutes
Calcium pyrophosphate
RhBMP-2

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics

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title = "Effects of BMP-2 delivery in calcium phosphate bone graft materials with different compositions on bone regeneration",

abstract = "This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated using in-vitro and in-vivo tests. New bone area percentages (%) in the BCP/BMP and CPP/BMP groups were significantly greater than in the BCP and CPP groups. At weeks 4 and 8 post-implantation, CPP/BMP showed the most new bone growth. Within the limitations of this study, treatment of BCP and CPP with rhBMP-2 significantly enhanced bone regeneration. CPP was found to be a suitable carrier for rhBMP-2.",

keywords = "Alloplast, Biphasic calcium phosphate, Bone substitutes, Calcium pyrophosphate, RhBMP-2",

author = "Park, {Jin Chul} and Bae, {Eun Bin} and Kim, {Se Eun} and Kim, {So Yun} and Choi, {Kyung Hee} and Choi, {Jae Won} and Bae, {Ji Hyeon} and Ryu, {Jae Jun} and Huh, {Jung Bo}",

note = "Funding Information: Acknowledgments: This study was supported by a research grant (2 years) from Pusan National University, South Korea Publisher Copyright: {\textcopyright} 2016 by the authors.",

year = "2016",

doi = "10.3390/ma9110954",

language = "English",

volume = "9",

journal = "Materials",

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AU - Park, Jin Chul

AU - Bae, Eun Bin

AU - Kim, Se Eun

AU - Kim, So Yun

AU - Choi, Kyung Hee

AU - Choi, Jae Won

AU - Bae, Ji Hyeon

AU - Ryu, Jae Jun

AU - Huh, Jung Bo

PY - 2016

Y1 - 2016

N2 - This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated using in-vitro and in-vivo tests. New bone area percentages (%) in the BCP/BMP and CPP/BMP groups were significantly greater than in the BCP and CPP groups. At weeks 4 and 8 post-implantation, CPP/BMP showed the most new bone growth. Within the limitations of this study, treatment of BCP and CPP with rhBMP-2 significantly enhanced bone regeneration. CPP was found to be a suitable carrier for rhBMP-2.

AB - This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated using in-vitro and in-vivo tests. New bone area percentages (%) in the BCP/BMP and CPP/BMP groups were significantly greater than in the BCP and CPP groups. At weeks 4 and 8 post-implantation, CPP/BMP showed the most new bone growth. Within the limitations of this study, treatment of BCP and CPP with rhBMP-2 significantly enhanced bone regeneration. CPP was found to be a suitable carrier for rhBMP-2.

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JO - Materials

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ER -

Effects of BMP-2 delivery in calcium phosphate bone graft materials with different compositions on bone regeneration

Abstract

Keywords

ASJC Scopus subject areas

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