Effects of bone morphogenetic protein-7 (BMP-7) on primordial follicular growth in the mouse ovary

Woo Sik Lee, Se Jin Yoon, Tae Ki Yoon, Kwang Yul Cha, Sook Hwan Lee, Shunichi Shimasaki, Sangho Lee, Kyung Ah Lee

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88 Citations (Scopus)


Previously, bone morphogenetic protein-7 (BMP-7) was suggested as a factor that may act to facilitate the transition of follicles from primordial stage to the pool of developed primary, preantral, and antral follicles (Lee et al. 2001: Biol Reprod 65:994-999.). Thus, aim of the present study was to evaluate effect(s) of BMP-7 on the primordial-primary follicle transition. Neonatal mouse ovaries were cultured in the presence or absence of 100 mIU/ml FSH with various doses of BMP-7 (0, 10, and 100 ng/ml). After 4-day culture period, number of follicles was counted and the expression of transcripts for FSH receptor (FSHR), kit ligand (KL), and c-kit was measured by RT-PCR. BMP-7 alone at 100 ng/ml concentration stimulated follicle development with concurrent increase of mRNA for FSHR. BMP-7 alone down-regulated KL expression however, the ratio between KL1 and KL2 was increased. There was no change in the c-kit mRNA expression. Results of the present study suggest that the BMP-7 is one of the factors involved in primordial-primary follicle transition in the mouse ovary and it may play a role in expression of FSHR for further follicular development.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalMolecular Reproduction and Development
Issue number2
Publication statusPublished - 2004 Oct


  • BMP-7
  • C-kit
  • Kit ligand
  • Mouse
  • Primordial-primary follicle transition

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology


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