Effects of chronic kidney disease on clinical outcomes in patients with peripheral artery disease undergoing endovascular treatment: Analysis from the K-VIS ELLA registry

other The Korean Vascular Intervention Society (K-VIS) Endovascular therapy in Lower Limb Artery diseases registry (ELLA) Registry Investigators

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Chronic kidney disease (CKD) is a risk factor for peripheral artery disease (PAD), but the impact of CKD in PAD patients who received endovascular treatment (EVT) is not well studied. Aim of this study is to clarify the impact of CKD in patients with PAD in real EVT era. Methods: Using the Korean Vascular Intervention Society (K-VIS) endovascular therapy in lower limb artery disease registry (ELLA) registry, we analyzed 3434 patients who underwent EVT. Baseline characteristics, in-hospital events, and overall- and major adverse limb events (MALE)-free survival were analyzed. Results: 2739 patients (3548 target limbs) were included. 272 patients featured CKD (9.9%). Limbs in CKD patients had higher Rutherford scores, higher prevalence of critical limb ischemia (CLI). There were no differences in technical success rates in non-CKD vs. CKD group comparison and non-severe CKD vs. severe CKD group comparison (p = 0.050, 0.581, respectively). In-hospital death (p < 0.001) and short-term unexpected amputation (p = 0.028) were more frequent in the CKD group. The short-term outcome differences between severe and non-severe CKD were insignificant. Kaplan–Meier curves favored overall and MALE-free survival in non-CKD patients compared with CKD patients, but there was no difference in overall- or MALE-free survival between non-severe CKD and severe CKD groups. Conclusion: PAD patients with CKD showed worse short-term mortality, short-term unexpected amputation outcome, and overall- and MALE-free survival than those without CKD in real EVT era. These findings might provide additive prognostic information for PAD patients with CKD who will be treated with EVT.

Original languageEnglish
JournalInternational Journal of Cardiology
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Peripheral Arterial Disease
Chronic Renal Insufficiency
Blood Vessels
Registries
Extremities
Therapeutics
Disease-Free Survival
Kidney Diseases
Amputation

Keywords

  • Chronic kidney disease
  • Endovascular treatment
  • Peripheral artery disease
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

other The Korean Vascular Intervention Society (K-VIS) Endovascular therapy in Lower Limb Artery diseases registry (ELLA) Registry Investigators (Accepted/In press). Effects of chronic kidney disease on clinical outcomes in patients with peripheral artery disease undergoing endovascular treatment: Analysis from the K-VIS ELLA registry. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2018.03.108

Effects of chronic kidney disease on clinical outcomes in patients with peripheral artery disease undergoing endovascular treatment : Analysis from the K-VIS ELLA registry. / other The Korean Vascular Intervention Society (K-VIS) Endovascular therapy in Lower Limb Artery diseases registry (ELLA) Registry Investigators.

In: International Journal of Cardiology, 01.01.2018.

Research output: Contribution to journalArticle

other The Korean Vascular Intervention Society (K-VIS) Endovascular therapy in Lower Limb Artery diseases registry (ELLA) Registry Investigators. / Effects of chronic kidney disease on clinical outcomes in patients with peripheral artery disease undergoing endovascular treatment : Analysis from the K-VIS ELLA registry. In: International Journal of Cardiology. 2018.
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title = "Effects of chronic kidney disease on clinical outcomes in patients with peripheral artery disease undergoing endovascular treatment: Analysis from the K-VIS ELLA registry",
abstract = "Objectives: Chronic kidney disease (CKD) is a risk factor for peripheral artery disease (PAD), but the impact of CKD in PAD patients who received endovascular treatment (EVT) is not well studied. Aim of this study is to clarify the impact of CKD in patients with PAD in real EVT era. Methods: Using the Korean Vascular Intervention Society (K-VIS) endovascular therapy in lower limb artery disease registry (ELLA) registry, we analyzed 3434 patients who underwent EVT. Baseline characteristics, in-hospital events, and overall- and major adverse limb events (MALE)-free survival were analyzed. Results: 2739 patients (3548 target limbs) were included. 272 patients featured CKD (9.9{\%}). Limbs in CKD patients had higher Rutherford scores, higher prevalence of critical limb ischemia (CLI). There were no differences in technical success rates in non-CKD vs. CKD group comparison and non-severe CKD vs. severe CKD group comparison (p = 0.050, 0.581, respectively). In-hospital death (p < 0.001) and short-term unexpected amputation (p = 0.028) were more frequent in the CKD group. The short-term outcome differences between severe and non-severe CKD were insignificant. Kaplan–Meier curves favored overall and MALE-free survival in non-CKD patients compared with CKD patients, but there was no difference in overall- or MALE-free survival between non-severe CKD and severe CKD groups. Conclusion: PAD patients with CKD showed worse short-term mortality, short-term unexpected amputation outcome, and overall- and MALE-free survival than those without CKD in real EVT era. These findings might provide additive prognostic information for PAD patients with CKD who will be treated with EVT.",
keywords = "Chronic kidney disease, Endovascular treatment, Peripheral artery disease, Prognosis",
author = "{other The Korean Vascular Intervention Society (K-VIS) Endovascular therapy in Lower Limb Artery diseases registry (ELLA) Registry Investigators} and Kim, {Hyung Oh} and Kim, {Jae Min} and Woo, {Jong Shin} and Donghoon Choi and Ko, {Young Guk} and Ahn, {Chul Min} and Lee, {Seung Whan} and Lee, {Jae Hwan} and Choi, {Seung Hyuk} and Yu, {Cheol Woong} and Min, {Pil Ki} and Yoon, {Chang Hwan} and Chae, {In ho} and Lee, {Sang Rok} and Koh, {Yoon Seok} and Weon Kim",
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T1 - Effects of chronic kidney disease on clinical outcomes in patients with peripheral artery disease undergoing endovascular treatment

T2 - Analysis from the K-VIS ELLA registry

AU - other The Korean Vascular Intervention Society (K-VIS) Endovascular therapy in Lower Limb Artery diseases registry (ELLA) Registry Investigators

AU - Kim, Hyung Oh

AU - Kim, Jae Min

AU - Woo, Jong Shin

AU - Choi, Donghoon

AU - Ko, Young Guk

AU - Ahn, Chul Min

AU - Lee, Seung Whan

AU - Lee, Jae Hwan

AU - Choi, Seung Hyuk

AU - Yu, Cheol Woong

AU - Min, Pil Ki

AU - Yoon, Chang Hwan

AU - Chae, In ho

AU - Lee, Sang Rok

AU - Koh, Yoon Seok

AU - Kim, Weon

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives: Chronic kidney disease (CKD) is a risk factor for peripheral artery disease (PAD), but the impact of CKD in PAD patients who received endovascular treatment (EVT) is not well studied. Aim of this study is to clarify the impact of CKD in patients with PAD in real EVT era. Methods: Using the Korean Vascular Intervention Society (K-VIS) endovascular therapy in lower limb artery disease registry (ELLA) registry, we analyzed 3434 patients who underwent EVT. Baseline characteristics, in-hospital events, and overall- and major adverse limb events (MALE)-free survival were analyzed. Results: 2739 patients (3548 target limbs) were included. 272 patients featured CKD (9.9%). Limbs in CKD patients had higher Rutherford scores, higher prevalence of critical limb ischemia (CLI). There were no differences in technical success rates in non-CKD vs. CKD group comparison and non-severe CKD vs. severe CKD group comparison (p = 0.050, 0.581, respectively). In-hospital death (p < 0.001) and short-term unexpected amputation (p = 0.028) were more frequent in the CKD group. The short-term outcome differences between severe and non-severe CKD were insignificant. Kaplan–Meier curves favored overall and MALE-free survival in non-CKD patients compared with CKD patients, but there was no difference in overall- or MALE-free survival between non-severe CKD and severe CKD groups. Conclusion: PAD patients with CKD showed worse short-term mortality, short-term unexpected amputation outcome, and overall- and MALE-free survival than those without CKD in real EVT era. These findings might provide additive prognostic information for PAD patients with CKD who will be treated with EVT.

AB - Objectives: Chronic kidney disease (CKD) is a risk factor for peripheral artery disease (PAD), but the impact of CKD in PAD patients who received endovascular treatment (EVT) is not well studied. Aim of this study is to clarify the impact of CKD in patients with PAD in real EVT era. Methods: Using the Korean Vascular Intervention Society (K-VIS) endovascular therapy in lower limb artery disease registry (ELLA) registry, we analyzed 3434 patients who underwent EVT. Baseline characteristics, in-hospital events, and overall- and major adverse limb events (MALE)-free survival were analyzed. Results: 2739 patients (3548 target limbs) were included. 272 patients featured CKD (9.9%). Limbs in CKD patients had higher Rutherford scores, higher prevalence of critical limb ischemia (CLI). There were no differences in technical success rates in non-CKD vs. CKD group comparison and non-severe CKD vs. severe CKD group comparison (p = 0.050, 0.581, respectively). In-hospital death (p < 0.001) and short-term unexpected amputation (p = 0.028) were more frequent in the CKD group. The short-term outcome differences between severe and non-severe CKD were insignificant. Kaplan–Meier curves favored overall and MALE-free survival in non-CKD patients compared with CKD patients, but there was no difference in overall- or MALE-free survival between non-severe CKD and severe CKD groups. Conclusion: PAD patients with CKD showed worse short-term mortality, short-term unexpected amputation outcome, and overall- and MALE-free survival than those without CKD in real EVT era. These findings might provide additive prognostic information for PAD patients with CKD who will be treated with EVT.

KW - Chronic kidney disease

KW - Endovascular treatment

KW - Peripheral artery disease

KW - Prognosis

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