Effects of Cornus walteri extract on hepatic lipid-regulating enzyme activities in high fat diet-induced obese rats

Sung Ho Yun, Junsoo Lee, Hyung Joo Suh, Eun Young Jung

Research output: Contribution to journalArticle

Abstract

In this study, we investigated whether the body fat suppressive effects of Cornus walteri extract (CE) were due to alterations in lipid-regulating enzyme activities in high fat diet-induced obese rats. Male Sprague-Dawley rats were randomly divided into three groups (n=6): A normal diet group (N-control), a high fat diet group (F-control), and a high fat diet group, treated orally with CE (0.25%) in their drinking water (Treatment). After five weeks, CE supplementation tended to reduce body-weight gain and visceral fat in the diet-induced obese rats. The activity of hepatic glucose-6-phosphate dehydrogenase (G6PD) and malic enzyme (ME), responsible for fatty acid synthesis, tended to be lower in the Treatment group compared to the non-treated groups. This finding indicates that the body fat suppressive effects of CE are most likely due to decreases in hepatic fatty acid synthesis. CE supplementation increased hepatic carnitine palmitoyltransferase (CPT) activity, which suggests that β-oxidation was enhanced. In conclusion, CE supplementation suppressed body fat accumulation by attenuating fatty acid synthesis and enhancing β-oxidation through alteration of lipid-regulating enzyme activities.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalProgress in Nutrition
Volume20
DOIs
Publication statusPublished - 2018 Jul 1

Keywords

  • Body fat
  • Carnitine palmitoyltransferase
  • Cornus walteri
  • Glucose-6-phosphate dehydrogenase
  • Malic enzyme

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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