Effects of CYP2D6 and CYP3A5 genotypes on the plasma concentrations of risperidone and 9-hydroxyrisperidone in Korean schizophrenic patients

Rhee Hun Kang, Sun Min Jung, Kyoung Ah Kim, Duk Ki Lee, Hyun Kee Cho, Bong Joo Jung, Young Ku Kim, Seung Hyun Kim, Changsu Han, Min Soo Lee, Ji Young Park

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    40 Citations (Scopus)

    Abstract

    This study was conducted to evaluate the effects of the CYP2D6 and CYP3A5 genotypes on the steady-state plasma levels of risperidone (RIS), 9-hydroxyrisperidone (9-OH-RIS), and the active moiety (RIS plus 9-OH-RIS) in Korean schizophrenic patients. Sixty-four Korean schizophrenic patients were enrolled. CYP2D6 and CYP3A5 genotypes were determined, and the plasma levels of RIS and 9-OH-RIS were measured using high-performance liquid chromatography. The dose-normalized plasma concentrations of RIS, 9-OH-RIS, and the active moiety were compared according to the CYP2D6 and CYP3A5 genotypes. Among the patients, 57 were CYP2D6 extensive metabolizers (EMs; CYP2D6*1/*1,*1/ *10, and*10/*10) and 7 were CYP2D6 poor metabolizers (PMs; CYP2D6*1/*5 and*10/*5). For the CYP3A5 genotype, 30 patients were CYP3A5*1 expressors (*1/*1 [n ≤ 1] and*1/*3 [n ≤ 29]) and 34 patients were CYP3A5 nonexpressors (*3/*3). The plasma levels of RIS (2.03 ng/mL per milligram for EMs vs 5.57 ng/mL per milligram for PMs, P < 0.001) and 9-OH-RIS (5.06 ng/mL per milligram for EMs vs 0.22 ng/mL per milligram for PMs, P < 0.001) were significantly different among CYP2D6 genotype groups, but the CYP2D6 EMs (7.09 ng/mL per milligram) and PMs (5.79 ng/mL per milligram) did not show no difference in the levels of the active moiety (P ≤ 0.470). CYP3A5 nonexpressors exhibited higher plasma concentrations of both RIS and 9-OH-RIS than its expressors. In the case of 9-OH-RIS, CYP3A5 nonexpressors exhibited significantly higher concentrations than CYP3A5 expressors (5.42 vs 3.51 ng/mL per milligram, P ≤ 0.022). In addition, concentrations of the active moiety were also significantly different between the CYP3A5 nonexpressors (8.39 ng/mL per milligram) and expressors (5.30 ng/mL per milligram, P ≤ 0.005). In conclusion, both CYP2D6 and CYP3A5 genotypes affected plasma levels of RIS and 9-OH-RIS, whereas the active moiety levels were influenced only by the CYP3A5 genotype but not by the CYP2D6 genotype.

    Original languageEnglish
    Pages (from-to)272-277
    Number of pages6
    JournalJournal of Clinical Psychopharmacology
    Volume29
    Issue number3
    DOIs
    Publication statusPublished - 2009 Jun

    Keywords

    • 9-hydroxyrisperidone
    • Cytochrome P450 2D6 (CYP2D6)
    • Cytochrome P450 3A5 (CYP3A5)
    • Pharmacogenetics
    • Risperidone

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Pharmacology (medical)

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