Effects of CYP3A5, CYP2C19, and CYP2B6 on the clinical efficacy and adverse outcomes of sibutramine therapy: A crucial role for the CYP2B6*6 allele

In Cheol Hwang, Ji Young Park, Hong Yup Ahn, Kyoung Kon Kim, Heuy Sun Suh, Ki Dong Ko, Kyoung Ah Kim

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Background: Various cytochrome P450 isoforms modulate sibutramine activity and influence sibutramine plasma levels and pharmacokinetics. However, there are no available data to demonstrate the association of these polymorphisms with the clinical outcomes of sibutramine administration. Methods: This study was a sub-investigation of a 12-week, double-blind, placebo-controlled trial examining the additive effect of orlistat on sibutramine. The final analysis was restricted to 101 women who had fulfilled the protocol. We evaluated the effects of genetic polymorphisms of CYP3A5, CYP2C19 and CYP2B6 on the % weight loss and the occurrence of adverse events. Results: The change of pulse rate from baseline value was affected by both CYP2B6 and CYP3A5 genetic polymorphisms (P < .01 for CYP3A5 and P = .01 for CYP2B6). Both CYP2B6 and CYP3A5 showed gene-gene interactions (P < .01). After adjusting for significant variables in the backward stepwise regression model, the change of pulse rate and time-dependent weight reduction were significant only among the CYP2B6 genotypes (P = .027 and P < .01, respectively). Conclusion: The CYP2B6*6 allele influences the extent of weight reduction and pulse rate changes in patients undergoing sibutramine treatment.

    Original languageEnglish
    Pages (from-to)77-81
    Number of pages5
    JournalClinica Chimica Acta
    Volume428
    DOIs
    Publication statusPublished - 2014 Jan 20

    Keywords

    • CYP2B6
    • Polymorphisms
    • Sibutramine

    ASJC Scopus subject areas

    • Biochemistry
    • Clinical Biochemistry
    • Biochemistry, medical

    Fingerprint

    Dive into the research topics of 'Effects of CYP3A5, CYP2C19, and CYP2B6 on the clinical efficacy and adverse outcomes of sibutramine therapy: A crucial role for the CYP2B6*6 allele'. Together they form a unique fingerprint.

    Cite this