Effects of deer bone extract on the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced osteoarthritic rats

Hyunji Lee, Hyeon Son Choi, Yooheon Park, Chang W on Ahn, Sung U g Jung, Soo H yun Park, Hyung Joo Suh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Deer bone extract has the potential to relieve the discomfort or the articular cartilaginous damage associated with osteoarthritic (OA) and may be useful as a natural supplement for OA treatment without serious side effects. We analyzed the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced OA rats. Increases in the levels of serum pro-inflammatory cytokines, such as interleukin-1β, interleukin-6, and tumor necrosis factor-α were significantly inhibited by the administration of deer bone extract (p<0.05). Decreases in the expression of collagen type II (COL2) and tissue inhibitors of metalloproteinases (TIMPs) mRNAs in the cartilage were significantly inhibited by deer bone extract treatment (p<0.05). The deer bone extract significantly suppressed the expression of matrix metalloproteinases (MMPs) mRNAs in the cartilage. The deer bone extract induced the up-regulation of COL2 and TIMP mRNAs and the down-regulation of MMP mRNAs by suppressing the expression of pro-inflammatory cytokine mRNAs.

Original languageEnglish
Pages (from-to)1703-1709
Number of pages7
JournalBioscience, biotechnology, and biochemistry
Volume78
Issue number10
DOIs
Publication statusPublished - 2014

Keywords

  • deer bone extract
  • matrix metalloproteinase
  • osteoarthritis
  • pro-inflammatory cytokines
  • tissue inhibitors of metalloproteinases

ASJC Scopus subject areas

  • Medicine(all)

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