Effects of deer bone extract on the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced osteoarthritic rats

Hyunji Lee, Hyeon Son Choi, Yooheon Park, Chang W on Ahn, Sung U g Jung, Soo H yun Park, Hyung Joo Suh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Deer bone extract has the potential to relieve the discomfort or the articular cartilaginous damage associated with osteoarthritic (OA) and may be useful as a natural supplement for OA treatment without serious side effects. We analyzed the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced OA rats. Increases in the levels of serum pro-inflammatory cytokines, such as interleukin-1β, interleukin-6, and tumor necrosis factor-α were significantly inhibited by the administration of deer bone extract (p<0.05). Decreases in the expression of collagen type II (COL2) and tissue inhibitors of metalloproteinases (TIMPs) mRNAs in the cartilage were significantly inhibited by deer bone extract treatment (p<0.05). The deer bone extract significantly suppressed the expression of matrix metalloproteinases (MMPs) mRNAs in the cartilage. The deer bone extract induced the up-regulation of COL2 and TIMP mRNAs and the down-regulation of MMP mRNAs by suppressing the expression of pro-inflammatory cytokine mRNAs.

Original languageEnglish
Pages (from-to)1703-1709
Number of pages7
JournalBioscience, biotechnology, and biochemistry
Volume78
Issue number10
DOIs
Publication statusPublished - 2014

Fingerprint

Iodoacetates
Deer
Cartilage
Rats
Bone
Genes
Cytokines
Bone and Bones
Messenger RNA
Tissue Inhibitor of Metalloproteinases
Matrix Metalloproteinases
Collagen Type II
Interleukin-1
Interleukin-6
Up-Regulation
Down-Regulation
Tumor Necrosis Factor-alpha
Joints
Serum

Keywords

  • deer bone extract
  • matrix metalloproteinase
  • osteoarthritis
  • pro-inflammatory cytokines
  • tissue inhibitors of metalloproteinases

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of deer bone extract on the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced osteoarthritic rats. / Lee, Hyunji; Choi, Hyeon Son; Park, Yooheon; Ahn, Chang W on; Jung, Sung U g; Park, Soo H yun; Suh, Hyung Joo.

In: Bioscience, biotechnology, and biochemistry, Vol. 78, No. 10, 2014, p. 1703-1709.

Research output: Contribution to journalArticle

Lee, Hyunji ; Choi, Hyeon Son ; Park, Yooheon ; Ahn, Chang W on ; Jung, Sung U g ; Park, Soo H yun ; Suh, Hyung Joo. / Effects of deer bone extract on the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced osteoarthritic rats. In: Bioscience, biotechnology, and biochemistry. 2014 ; Vol. 78, No. 10. pp. 1703-1709.
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