Effects of electroacupuncture on capsaicin-induced model of atopic dermatitis in rats

Dal Lim Jung, Seung Deok Lee, In Hwa Choi, Heung Sik Na, Seung Ug Hong

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Electroacupuncture (EA) is used as a prescription to treat pruritus and atopic dermatitis. Whether EA affects experimental itch in rat models of immunologic or neuronal damages, however, is unknown. Objectives: The present study was designed to determine the therapeutic effects of high-frequency EA on atopic dermatitis-like lesions in rats. Materials and methods: Capsaicin (50. mg/kg) was subcutaneously administered rat pups within 48. h after birth. Rats then underwent 30. min of EA at six acupoints (bilateral BL13, and unilateral LI11, ST36, SP10, SP6) every other day (EA group) for 3 weeks. Measurements of IgE, mast cells, scratching behavior, dynorphin release, skin thickness and dermatitis score were obtained. Results: Only the dermatitis score and dynorphin expression were decreased in the EA group compared with the control non-EA group. Conclusion: We suggest that high-frequency EA alleviates pruritus of atopic dermatitis-like lesions in rats induced by capsaicin injection, via the release of dynorphin. These findings indicate a new potential therapeutic approach for the amelioration of symptoms of atopic dermatitis.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalJournal of Dermatological Science
Volume74
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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Electroacupuncture
Capsaicin
Atopic Dermatitis
Rats
Dynorphins
Dermatitis
Pruritus
Immunological Models
Acupuncture Points
Therapeutic Uses
Mast Cells
Immunoglobulin E
Prescriptions
Skin
Parturition
Injections

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Molecular Biology

Cite this

Effects of electroacupuncture on capsaicin-induced model of atopic dermatitis in rats. / Jung, Dal Lim; Lee, Seung Deok; Choi, In Hwa; Na, Heung Sik; Hong, Seung Ug.

In: Journal of Dermatological Science, Vol. 74, No. 1, 01.01.2014, p. 23-30.

Research output: Contribution to journalArticle

Jung, Dal Lim ; Lee, Seung Deok ; Choi, In Hwa ; Na, Heung Sik ; Hong, Seung Ug. / Effects of electroacupuncture on capsaicin-induced model of atopic dermatitis in rats. In: Journal of Dermatological Science. 2014 ; Vol. 74, No. 1. pp. 23-30.
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