Abstract
This study investigated whether and how electroacupuncture (EA) attenuates cold hypersensitivity (allodynia) in a rat model of oxaliplatin-induced neuropathic pain. Cold allodynia [evaluated by immersing the tail into cold water (4 C) and measuring the withdrawal latency] was induced 3 days after an oxaliplatin administration (6 mg/kg, i.p.). EA stimulation (2/100 Hz, 0.3-ms pulse duration, 0.2-0.3 mA) was delivered to ST36 acupoint or non-acupoint for 20 min. Low-frequency (2 Hz) EA at ST36 relieved cold allodynia more effectively than high-frequency EA at ST36 or low-frequency EA at non-acupoint. Naloxone (opioid antagonist, 2 mg/kg, i.p.) completely blocked such EA-induced anti-allodynia, whereas phentolamine (α-adrenergic antagonist, 2 mg/kg, i.p.) did not. Moreover, plasma β-endorphin levels significantly increased right after the end of EA and subsequently decreased. These results indicate that low-frequency EA at ST36 in rats has a marked relieving effect on oxaliplatin-induced cold allodynia that is mediated by the endogenous opioid, but not noradrenergic, system.
| Original language | English |
|---|---|
| Pages (from-to) | 151-156 |
| Number of pages | 6 |
| Journal | Journal of Physiological Sciences |
| Volume | 64 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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ASJC Scopus subject areas
- Physiology
Cite this
Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats. / Moon, Hak Jin; Lim, Bong Soo; Lee, Dae Il; Ye, Min Sook; Lee, Giseog; Min, Byung Il; Bae, Hyunsu; Na, Heung Sik; Kim, Sun Kwang.
In: Journal of Physiological Sciences, Vol. 64, No. 2, 01.01.2014, p. 151-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats
AU - Moon, Hak Jin
AU - Lim, Bong Soo
AU - Lee, Dae Il
AU - Ye, Min Sook
AU - Lee, Giseog
AU - Min, Byung Il
AU - Bae, Hyunsu
AU - Na, Heung Sik
AU - Kim, Sun Kwang
PY - 2014/1/1
Y1 - 2014/1/1
N2 - This study investigated whether and how electroacupuncture (EA) attenuates cold hypersensitivity (allodynia) in a rat model of oxaliplatin-induced neuropathic pain. Cold allodynia [evaluated by immersing the tail into cold water (4 C) and measuring the withdrawal latency] was induced 3 days after an oxaliplatin administration (6 mg/kg, i.p.). EA stimulation (2/100 Hz, 0.3-ms pulse duration, 0.2-0.3 mA) was delivered to ST36 acupoint or non-acupoint for 20 min. Low-frequency (2 Hz) EA at ST36 relieved cold allodynia more effectively than high-frequency EA at ST36 or low-frequency EA at non-acupoint. Naloxone (opioid antagonist, 2 mg/kg, i.p.) completely blocked such EA-induced anti-allodynia, whereas phentolamine (α-adrenergic antagonist, 2 mg/kg, i.p.) did not. Moreover, plasma β-endorphin levels significantly increased right after the end of EA and subsequently decreased. These results indicate that low-frequency EA at ST36 in rats has a marked relieving effect on oxaliplatin-induced cold allodynia that is mediated by the endogenous opioid, but not noradrenergic, system.
AB - This study investigated whether and how electroacupuncture (EA) attenuates cold hypersensitivity (allodynia) in a rat model of oxaliplatin-induced neuropathic pain. Cold allodynia [evaluated by immersing the tail into cold water (4 C) and measuring the withdrawal latency] was induced 3 days after an oxaliplatin administration (6 mg/kg, i.p.). EA stimulation (2/100 Hz, 0.3-ms pulse duration, 0.2-0.3 mA) was delivered to ST36 acupoint or non-acupoint for 20 min. Low-frequency (2 Hz) EA at ST36 relieved cold allodynia more effectively than high-frequency EA at ST36 or low-frequency EA at non-acupoint. Naloxone (opioid antagonist, 2 mg/kg, i.p.) completely blocked such EA-induced anti-allodynia, whereas phentolamine (α-adrenergic antagonist, 2 mg/kg, i.p.) did not. Moreover, plasma β-endorphin levels significantly increased right after the end of EA and subsequently decreased. These results indicate that low-frequency EA at ST36 in rats has a marked relieving effect on oxaliplatin-induced cold allodynia that is mediated by the endogenous opioid, but not noradrenergic, system.
KW - Cold allodynia
KW - Electroacupuncture
KW - Endogenous opioid
KW - Noradrenergic
KW - Oxaliplatin
UR - http://www.scopus.com/inward/record.url?scp=84895827497&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895827497&partnerID=8YFLogxK
U2 - 10.1007/s12576-013-0297-0
DO - 10.1007/s12576-013-0297-0
M3 - Article
C2 - 24158835
AN - SCOPUS:84895827497
VL - 64
SP - 151
EP - 156
JO - Journal of Physiological Sciences
JF - Journal of Physiological Sciences
SN - 1880-6546
IS - 2
ER -