Effects of endocytosis inhibitory drugs on rubella virus entry into VeroE6 cells

Sun Ho Kee, Eun Jin Cho, Jin Won Song, Kwang Sook Park, Luck Ju Baek, Ki Joon Song

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

It has been suggested that infectious entry of rubella virus (RV) is conducted by receptor mediated endocytosis. To explore the cellular entry mechanism of RV, inhibitory effects of drugs affecting various endocytic pathways on RV entry into VeroE6 cells were analyzed. Results showed that RV infectious entry into VeroE6 cells is mediated by clathrin-dependent endocytosis and not by caveolae-mediated endocytosis. Moreover, chemical inhibition of macropinocytosis such as treatments of amiloride, actin and microtubule- disrupting drug significantly reduced RV infection. Considering that macropinocytosis is inducible endocytosis by cellular stimulations, clathrin-mediated endocytosis is likely to be a major route of RV infectious entry.

Original languageEnglish
Pages (from-to)823-829
Number of pages7
JournalMicrobiology and Immunology
Volume48
Issue number11
DOIs
Publication statusPublished - 2004

Keywords

  • Clathrin
  • Endocytosis
  • Macropinocytosis
  • Rubella virus

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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