Effects of exposure of formaldehyde to a rat model of atopic dermatitis induced by Neonatal Capsaicin treatment

Rafael Taeho Han, Seung Keun Back, Jaehee Lee, Hye Young Kim, Hee Jin Kim, Heung Sik Na

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Atopic dermatitis is chronically relapsing pruritic eczema and prevails around the world especially in developed countries. Complex interactions between genetic and environmental factors are known to play an important role in the pathophysiology of atopic dermatitis. However, we still lack a detailed picture of the pathogenesis of this disease. Thus, it is of importance to develop appropriate animal models for elucidating the progression of atopic dermatitis. Moreover, investigating the effect of environmental factors such as air pollutants on atopic dermatitis expands understanding of the disease. Here, we describe a method for inducing atopic dermatitis in rats with neonatal capsaicin treatment and a protocol for exposure of a constant concentration of formaldehyde to rats to reveal effects on the development of atopic dermatitis in infantile and adolescent periods. These protocols have been successfully applied to several experiments and can be used for other substances.

Original languageEnglish
Article numbere55987
JournalJournal of Visualized Experiments
Volume2017
Issue number127
DOIs
Publication statusPublished - 2017 Sep 27

Fingerprint

Capsaicin
Atopic Dermatitis
Formaldehyde
Rats
Therapeutics
Air Pollutants
Eczema
Clinical Protocols
Developed Countries
Formaldehyde poisoning
Animals
Animal Models
Air
Experiments

Keywords

  • Air pollutant
  • Animal model
  • Atopic dermatitis
  • Capsaicin
  • Exposure
  • Formaldehyde
  • Immunology
  • Issue 127

ASJC Scopus subject areas

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Effects of exposure of formaldehyde to a rat model of atopic dermatitis induced by Neonatal Capsaicin treatment. / Han, Rafael Taeho; Back, Seung Keun; Lee, Jaehee; Kim, Hye Young; Kim, Hee Jin; Na, Heung Sik.

In: Journal of Visualized Experiments, Vol. 2017, No. 127, e55987, 27.09.2017.

Research output: Contribution to journalArticle

Han, Rafael Taeho ; Back, Seung Keun ; Lee, Jaehee ; Kim, Hye Young ; Kim, Hee Jin ; Na, Heung Sik. / Effects of exposure of formaldehyde to a rat model of atopic dermatitis induced by Neonatal Capsaicin treatment. In: Journal of Visualized Experiments. 2017 ; Vol. 2017, No. 127.
@article{543ddbd1828744c6be62645711c5348e,
title = "Effects of exposure of formaldehyde to a rat model of atopic dermatitis induced by Neonatal Capsaicin treatment",
abstract = "Atopic dermatitis is chronically relapsing pruritic eczema and prevails around the world especially in developed countries. Complex interactions between genetic and environmental factors are known to play an important role in the pathophysiology of atopic dermatitis. However, we still lack a detailed picture of the pathogenesis of this disease. Thus, it is of importance to develop appropriate animal models for elucidating the progression of atopic dermatitis. Moreover, investigating the effect of environmental factors such as air pollutants on atopic dermatitis expands understanding of the disease. Here, we describe a method for inducing atopic dermatitis in rats with neonatal capsaicin treatment and a protocol for exposure of a constant concentration of formaldehyde to rats to reveal effects on the development of atopic dermatitis in infantile and adolescent periods. These protocols have been successfully applied to several experiments and can be used for other substances.",
keywords = "Air pollutant, Animal model, Atopic dermatitis, Capsaicin, Exposure, Formaldehyde, Immunology, Issue 127",
author = "Han, {Rafael Taeho} and Back, {Seung Keun} and Jaehee Lee and Kim, {Hye Young} and Kim, {Hee Jin} and Na, {Heung Sik}",
year = "2017",
month = "9",
day = "27",
doi = "10.3791/55987",
language = "English",
volume = "2017",
journal = "Journal of Visualized Experiments",
issn = "1940-087X",
publisher = "MYJoVE Corporation",
number = "127",

}

TY - JOUR

T1 - Effects of exposure of formaldehyde to a rat model of atopic dermatitis induced by Neonatal Capsaicin treatment

AU - Han, Rafael Taeho

AU - Back, Seung Keun

AU - Lee, Jaehee

AU - Kim, Hye Young

AU - Kim, Hee Jin

AU - Na, Heung Sik

PY - 2017/9/27

Y1 - 2017/9/27

N2 - Atopic dermatitis is chronically relapsing pruritic eczema and prevails around the world especially in developed countries. Complex interactions between genetic and environmental factors are known to play an important role in the pathophysiology of atopic dermatitis. However, we still lack a detailed picture of the pathogenesis of this disease. Thus, it is of importance to develop appropriate animal models for elucidating the progression of atopic dermatitis. Moreover, investigating the effect of environmental factors such as air pollutants on atopic dermatitis expands understanding of the disease. Here, we describe a method for inducing atopic dermatitis in rats with neonatal capsaicin treatment and a protocol for exposure of a constant concentration of formaldehyde to rats to reveal effects on the development of atopic dermatitis in infantile and adolescent periods. These protocols have been successfully applied to several experiments and can be used for other substances.

AB - Atopic dermatitis is chronically relapsing pruritic eczema and prevails around the world especially in developed countries. Complex interactions between genetic and environmental factors are known to play an important role in the pathophysiology of atopic dermatitis. However, we still lack a detailed picture of the pathogenesis of this disease. Thus, it is of importance to develop appropriate animal models for elucidating the progression of atopic dermatitis. Moreover, investigating the effect of environmental factors such as air pollutants on atopic dermatitis expands understanding of the disease. Here, we describe a method for inducing atopic dermatitis in rats with neonatal capsaicin treatment and a protocol for exposure of a constant concentration of formaldehyde to rats to reveal effects on the development of atopic dermatitis in infantile and adolescent periods. These protocols have been successfully applied to several experiments and can be used for other substances.

KW - Air pollutant

KW - Animal model

KW - Atopic dermatitis

KW - Capsaicin

KW - Exposure

KW - Formaldehyde

KW - Immunology

KW - Issue 127

UR - http://www.scopus.com/inward/record.url?scp=85031006075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031006075&partnerID=8YFLogxK

U2 - 10.3791/55987

DO - 10.3791/55987

M3 - Article

VL - 2017

JO - Journal of Visualized Experiments

JF - Journal of Visualized Experiments

SN - 1940-087X

IS - 127

M1 - e55987

ER -