Abstract
Atopic dermatitis is chronically relapsing pruritic eczema and prevails around the world especially in developed countries. Complex interactions between genetic and environmental factors are known to play an important role in the pathophysiology of atopic dermatitis. However, we still lack a detailed picture of the pathogenesis of this disease. Thus, it is of importance to develop appropriate animal models for elucidating the progression of atopic dermatitis. Moreover, investigating the effect of environmental factors such as air pollutants on atopic dermatitis expands understanding of the disease. Here, we describe a method for inducing atopic dermatitis in rats with neonatal capsaicin treatment and a protocol for exposure of a constant concentration of formaldehyde to rats to reveal effects on the development of atopic dermatitis in infantile and adolescent periods. These protocols have been successfully applied to several experiments and can be used for other substances.
| Original language | English |
|---|---|
| Article number | e55987 |
| Journal | Journal of Visualized Experiments |
| Volume | 2017 |
| Issue number | 127 |
| DOIs | |
| Publication status | Published - 2017 Sept 27 |
Keywords
- Air pollutant
- Animal model
- Atopic dermatitis
- Capsaicin
- Exposure
- Formaldehyde
- Immunology
- Issue 127
ASJC Scopus subject areas
- Neuroscience(all)
- Chemical Engineering(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)