Effects of exposure of formaldehyde to a rat model of atopic dermatitis induced by Neonatal Capsaicin treatment

Rafael Taeho Han, Seung Keun Back, Jaehee Lee, Hye Young Kim, Hee Jin Kim, Heung Sik Na

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Atopic dermatitis is chronically relapsing pruritic eczema and prevails around the world especially in developed countries. Complex interactions between genetic and environmental factors are known to play an important role in the pathophysiology of atopic dermatitis. However, we still lack a detailed picture of the pathogenesis of this disease. Thus, it is of importance to develop appropriate animal models for elucidating the progression of atopic dermatitis. Moreover, investigating the effect of environmental factors such as air pollutants on atopic dermatitis expands understanding of the disease. Here, we describe a method for inducing atopic dermatitis in rats with neonatal capsaicin treatment and a protocol for exposure of a constant concentration of formaldehyde to rats to reveal effects on the development of atopic dermatitis in infantile and adolescent periods. These protocols have been successfully applied to several experiments and can be used for other substances.

Original languageEnglish
Article numbere55987
JournalJournal of Visualized Experiments
Volume2017
Issue number127
DOIs
Publication statusPublished - 2017 Sep 27

Keywords

  • Air pollutant
  • Animal model
  • Atopic dermatitis
  • Capsaicin
  • Exposure
  • Formaldehyde
  • Immunology
  • Issue 127

ASJC Scopus subject areas

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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