Effects of extradural cortical stimulation on motor recovery in a rat model of subacute stroke

Won Hyuk Chang, Hyun Kim, Woong Sun, Joo Yeon Kim, Yong Il Shin, Yun Hee Kim

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Purpose: Previous studies demonstrated that administering extradural cortical stimulation (ECS) to rats during the acute phase of a photothrombotic infarct enhances motor recovery. However, the effect of ECS during the subacute phase was unknown.We aimed to evaluate the effects of ECS on motor recovery in a rat model of subacute photothrombotic stroke. Methods: Photothrombotic ischemic injury to the left sensorimotor cortex (SMC) was induced in 41 male Sprague-Dawley rats using Rose-bengal dye (20 mg/kg) and cold light. The rats were randomly divided into two groups: ECS on infarcted SMC (ECS group) and no ECS on infarcted SMC (non-stimulated group). The ECS group received continuous ECS for 14 days starting from day 5 after the stroke onset. Behavioral training with the single-pellet reaching task (SPRT) was performed daily for all of the rats from the fifth day after stroke onset. After 19 days, brain sections were immunostained to allow the quantification of infarct volumes and the evaluation of the neuronal markers. Results: The SPRT scores showed significantly faster and greater improvement in the ECS group than in the non-stimulated group. There were no significant differences in infarct size. However, in the ECS group, significantly more doublecortin-labeled cells were identified close to the penumbra region of the cerebral cortex. Conclusions: ECS in the subacute phase improved the behavior motor function in the stroke rat model, and induced a significant axonal sprouting in the peri-infarct area.

Original languageEnglish
Pages (from-to)589-596
Number of pages8
JournalRestorative Neurology and Neuroscience
Issue number5
Publication statusPublished - 2015 Oct 5


  • Axonal sprouting
  • extradural cortical stimulation
  • motor recovery
  • stroke

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology


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