Effects of Fermented Ginseng extracts on tumor metastasis in Mice

Dong Zhou Kang, Dan Liu, Seon Yoong Jo, Tae Bong Kang, Jin Moo Lee, Hyung Joo Suh, Ae jung Kim, Taek Joon Yoon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study was demonstrated that the fermentation of gingseng increases its biological activities, by comparing the anti-tumor and immunostimulating activities of fermented gingseng extracts (FginE) with those of non-fermented ginseng (GinE). In the experimental lung metastasis of colon26-M3.1 carcinoma, the intraperitoneal (i.p.) or peroral (p.o.) administration of FginE showed stronger anti-tumor metastatic activities than those of GinE. When stimulating 2 kinds of extract on macrophages, FginE was shown to have a higher production of interleukin (IL)-12 than GinE. In addition, treatment with FginE induced tumoricidal activity of peritoneal macrophages against colon26-M3.1 cells. When Peyer's patch was cocultured with FginE, the proliferation of these cells and granulocyte macrophage-colony stimulating factor (GMCSF) production were induced. In an assay for natural killer (NK) cell activity, an i.p. administration of FginE significantly augmented NK cytotoxicity against Yac-1 tumor cells. Fermented ginseng extracts promotes antitumor activities to inhibit tumor metastasis, and its antitumor effects are associated with the enhancement of systemic as well as mucosal immune systems.

Original languageEnglish
Pages (from-to)1559-1565
Number of pages7
JournalFood Science and Biotechnology
Volume19
Issue number6
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Panax
metastasis
Neoplasm Metastasis
neoplasms
mice
extracts
Neoplasms
Peyer's Patches
Peritoneal Macrophages
Interleukin-12
Granulocyte-Macrophage Colony-Stimulating Factor
Cell Extracts
Natural Killer Cells
Fermentation
Immune System
macrophages
Macrophages
Cell Proliferation
Carcinoma
granulocyte-macrophage colony-stimulating factor

Keywords

  • Cytokine
  • Fermented-ginseng
  • Innate immunity
  • Mucosal immunity
  • Tumor metastasis

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Kang, D. Z., Liu, D., Jo, S. Y., Kang, T. B., Lee, J. M., Suh, H. J., ... Yoon, T. J. (2010). Effects of Fermented Ginseng extracts on tumor metastasis in Mice. Food Science and Biotechnology, 19(6), 1559-1565. https://doi.org/10.1007/s10068-010-0221-9

Effects of Fermented Ginseng extracts on tumor metastasis in Mice. / Kang, Dong Zhou; Liu, Dan; Jo, Seon Yoong; Kang, Tae Bong; Lee, Jin Moo; Suh, Hyung Joo; Kim, Ae jung; Yoon, Taek Joon.

In: Food Science and Biotechnology, Vol. 19, No. 6, 01.12.2010, p. 1559-1565.

Research output: Contribution to journalArticle

Kang, DZ, Liu, D, Jo, SY, Kang, TB, Lee, JM, Suh, HJ, Kim, AJ & Yoon, TJ 2010, 'Effects of Fermented Ginseng extracts on tumor metastasis in Mice', Food Science and Biotechnology, vol. 19, no. 6, pp. 1559-1565. https://doi.org/10.1007/s10068-010-0221-9
Kang, Dong Zhou ; Liu, Dan ; Jo, Seon Yoong ; Kang, Tae Bong ; Lee, Jin Moo ; Suh, Hyung Joo ; Kim, Ae jung ; Yoon, Taek Joon. / Effects of Fermented Ginseng extracts on tumor metastasis in Mice. In: Food Science and Biotechnology. 2010 ; Vol. 19, No. 6. pp. 1559-1565.
@article{eb238252c9ff4c55bbd147a1bcfa7606,
title = "Effects of Fermented Ginseng extracts on tumor metastasis in Mice",
abstract = "This study was demonstrated that the fermentation of gingseng increases its biological activities, by comparing the anti-tumor and immunostimulating activities of fermented gingseng extracts (FginE) with those of non-fermented ginseng (GinE). In the experimental lung metastasis of colon26-M3.1 carcinoma, the intraperitoneal (i.p.) or peroral (p.o.) administration of FginE showed stronger anti-tumor metastatic activities than those of GinE. When stimulating 2 kinds of extract on macrophages, FginE was shown to have a higher production of interleukin (IL)-12 than GinE. In addition, treatment with FginE induced tumoricidal activity of peritoneal macrophages against colon26-M3.1 cells. When Peyer's patch was cocultured with FginE, the proliferation of these cells and granulocyte macrophage-colony stimulating factor (GMCSF) production were induced. In an assay for natural killer (NK) cell activity, an i.p. administration of FginE significantly augmented NK cytotoxicity against Yac-1 tumor cells. Fermented ginseng extracts promotes antitumor activities to inhibit tumor metastasis, and its antitumor effects are associated with the enhancement of systemic as well as mucosal immune systems.",
keywords = "Cytokine, Fermented-ginseng, Innate immunity, Mucosal immunity, Tumor metastasis",
author = "Kang, {Dong Zhou} and Dan Liu and Jo, {Seon Yoong} and Kang, {Tae Bong} and Lee, {Jin Moo} and Suh, {Hyung Joo} and Kim, {Ae jung} and Yoon, {Taek Joon}",
year = "2010",
month = "12",
day = "1",
doi = "10.1007/s10068-010-0221-9",
language = "English",
volume = "19",
pages = "1559--1565",
journal = "Food Science and Biotechnology",
issn = "1226-7708",
publisher = "Springer Netherlands",
number = "6",

}

TY - JOUR

T1 - Effects of Fermented Ginseng extracts on tumor metastasis in Mice

AU - Kang, Dong Zhou

AU - Liu, Dan

AU - Jo, Seon Yoong

AU - Kang, Tae Bong

AU - Lee, Jin Moo

AU - Suh, Hyung Joo

AU - Kim, Ae jung

AU - Yoon, Taek Joon

PY - 2010/12/1

Y1 - 2010/12/1

N2 - This study was demonstrated that the fermentation of gingseng increases its biological activities, by comparing the anti-tumor and immunostimulating activities of fermented gingseng extracts (FginE) with those of non-fermented ginseng (GinE). In the experimental lung metastasis of colon26-M3.1 carcinoma, the intraperitoneal (i.p.) or peroral (p.o.) administration of FginE showed stronger anti-tumor metastatic activities than those of GinE. When stimulating 2 kinds of extract on macrophages, FginE was shown to have a higher production of interleukin (IL)-12 than GinE. In addition, treatment with FginE induced tumoricidal activity of peritoneal macrophages against colon26-M3.1 cells. When Peyer's patch was cocultured with FginE, the proliferation of these cells and granulocyte macrophage-colony stimulating factor (GMCSF) production were induced. In an assay for natural killer (NK) cell activity, an i.p. administration of FginE significantly augmented NK cytotoxicity against Yac-1 tumor cells. Fermented ginseng extracts promotes antitumor activities to inhibit tumor metastasis, and its antitumor effects are associated with the enhancement of systemic as well as mucosal immune systems.

AB - This study was demonstrated that the fermentation of gingseng increases its biological activities, by comparing the anti-tumor and immunostimulating activities of fermented gingseng extracts (FginE) with those of non-fermented ginseng (GinE). In the experimental lung metastasis of colon26-M3.1 carcinoma, the intraperitoneal (i.p.) or peroral (p.o.) administration of FginE showed stronger anti-tumor metastatic activities than those of GinE. When stimulating 2 kinds of extract on macrophages, FginE was shown to have a higher production of interleukin (IL)-12 than GinE. In addition, treatment with FginE induced tumoricidal activity of peritoneal macrophages against colon26-M3.1 cells. When Peyer's patch was cocultured with FginE, the proliferation of these cells and granulocyte macrophage-colony stimulating factor (GMCSF) production were induced. In an assay for natural killer (NK) cell activity, an i.p. administration of FginE significantly augmented NK cytotoxicity against Yac-1 tumor cells. Fermented ginseng extracts promotes antitumor activities to inhibit tumor metastasis, and its antitumor effects are associated with the enhancement of systemic as well as mucosal immune systems.

KW - Cytokine

KW - Fermented-ginseng

KW - Innate immunity

KW - Mucosal immunity

KW - Tumor metastasis

UR - http://www.scopus.com/inward/record.url?scp=79959709468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959709468&partnerID=8YFLogxK

U2 - 10.1007/s10068-010-0221-9

DO - 10.1007/s10068-010-0221-9

M3 - Article

AN - SCOPUS:79959709468

VL - 19

SP - 1559

EP - 1565

JO - Food Science and Biotechnology

JF - Food Science and Biotechnology

SN - 1226-7708

IS - 6

ER -