Effects of fisetin supplementation on hepatic lipogenesis and glucose metabolism in Sprague-Dawley rats fed on a high fat diet

Yoonsu Cho, Ji Hyung Chung, Hyun Ju Do, Hyun Ju Jeon, Taewon Jin, Min Jeong Shin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The modulatory effects of daily fisetin supplementation for 8 weeks on genes involved in hepatic lipogenesis and gluconeogenesis and hyperglycemia in rats fed a high fat (HF) diet were evaluated. Elevated levels of triglyceride (TG), along with hepatic TG content and glucose concentrations in a high fat diet group were found to be reduced by fisetin supplementation. The high fat diet significantly increased hepatic mRNA expressions of PPARγ, SREBP 1C and SCD-1 genes in comparison to the control diet, which was subsequently reversed by supplementation with fisetin. In addition, fisetin supplementation significantly reduced hepatic mRNA abundance of FAS, ATPCL and G6Pase compared to the control group. Finally, epididymal mRNA abundance of GLUT4 was significantly increased by fisetin supplementation, compared to levels in the control and HF groups. Enhancement of GLUT4 expression by fisetin was further confirmed in differentiated 3T3-L1 adipocytes. Fisetin supplementation decreases cardiovascular risks by ameliorating hepatic steatosis and lowering circulating glucose concentrations.

Original languageEnglish
Pages (from-to)720-727
Number of pages8
JournalFood Chemistry
Volume139
Issue number1-4
DOIs
Publication statusPublished - 2013 Aug 15

Keywords

  • Fisetin
  • GLUT4
  • Lipogenesis
  • PPARγ
  • SREBP

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science

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