Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells

Mak Soon Lee, Chong Tai Kim, In-Hwan Kim, Yangha Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this study, we investigated the effects of Korean red ginseng water extract (KRGE) on hepatic lipid accumulation in HepG2 cells. KRGE decreased hepatic triglyceride and cholesterol levels. Further, KRGE suppressed expression of fatty acid synthase (FAS) and 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase. These results suggest that KRGE may reduce hepatic lipid accumulation by inhibition of FAS and HMG-CoA reductase expression in HepG2 cells.

Original languageEnglish
Pages (from-to)816-819
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume79
Issue number5
DOIs
Publication statusPublished - 2015

Fingerprint

Panax
Hep G2 Cells
Lipids
Fatty Acid Synthases
Water
Liver
Oxidoreductases
Triglycerides
Cholesterol
glutaryl-coenzyme A

Keywords

  • 3-hydroxy-3-methyl glutaryl coenzyme a (HMG-CoA) reductase
  • Fatty acid synthase (FAS)
  • Hepatic lipid accumulation
  • HepG2 cells
  • Korean red ginseng water extract (KRGE)

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells. / Lee, Mak Soon; Kim, Chong Tai; Kim, In-Hwan; Kim, Yangha.

In: Bioscience, Biotechnology and Biochemistry, Vol. 79, No. 5, 2015, p. 816-819.

Research output: Contribution to journalArticle

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