Effects of lactobacillus plantarum and leuconostoc mesenteroides probiotics on human seasonal and Avian Influenza Viruses

Joon Yong Bae, Jin Il Kim, Sehee Park, Kirim Yoo, In Ho Kim, Wooha Joo, Byung Hee Ryu, Mee Sook Park, Ilseob Lee, Man-Seong Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Influenza viruses that cause recurrent seasonal epidemics to humans can be controlled with vaccine and antiviral therapy. However, the medical treatments often exhibit limited efficacy in the elderly or immunosuppressed individuals. In these cases, daily uptake of probiotics may be an option to bring in health benefits against influenza. Here, we demonstrate the effects of probiotics Lactobacillus plantarum (Lp) and Leuconostoc mesenteroides (Lm) against seasonal and avian influenza viruses. As assessed by the plaque size reduction of human H1N1 and avian influenza H7N9 viruses, including green fluorescent protein-tagged H1N1 strain in cells, the selected Lp and Lm strains restrained viral replication in mouse lungs with statistical significance. Against lethal viral challenge, the Lp and Lm strains exhibited their beneficial effects by increasing the mean days and rates of survival of the infected mice. These results suggest that, despite rather narrow ranges of protective efficacy, the dietary supplement of Lactobacillus and Leuconostoc probiotics may promote health benefits against influenza.

Original languageEnglish
Pages (from-to)893-901
Number of pages9
JournalJournal of Microbiology and Biotechnology
Volume28
Issue number6
DOIs
Publication statusPublished - 2018 Jun 1

Fingerprint

Lactobacillus plantarum
Influenza in Birds
Probiotics
Orthomyxoviridae
Human Influenza
Insurance Benefits
H7N9 Subtype Influenza A Virus
Leuconostoc
Active Immunotherapy
Lactobacillus
Dietary Supplements
Green Fluorescent Proteins
Antiviral Agents
Survival Rate
Lung
Leuconostoc mesenteroides
Therapeutics

Keywords

  • Dietary supplement
  • Influenza
  • Lactobacillus plantarum
  • Leuconostoc mesenteroides
  • Probiotic

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Effects of lactobacillus plantarum and leuconostoc mesenteroides probiotics on human seasonal and Avian Influenza Viruses. / Bae, Joon Yong; Kim, Jin Il; Park, Sehee; Yoo, Kirim; Kim, In Ho; Joo, Wooha; Ryu, Byung Hee; Park, Mee Sook; Lee, Ilseob; Park, Man-Seong.

In: Journal of Microbiology and Biotechnology, Vol. 28, No. 6, 01.06.2018, p. 893-901.

Research output: Contribution to journalArticle

Bae, Joon Yong ; Kim, Jin Il ; Park, Sehee ; Yoo, Kirim ; Kim, In Ho ; Joo, Wooha ; Ryu, Byung Hee ; Park, Mee Sook ; Lee, Ilseob ; Park, Man-Seong. / Effects of lactobacillus plantarum and leuconostoc mesenteroides probiotics on human seasonal and Avian Influenza Viruses. In: Journal of Microbiology and Biotechnology. 2018 ; Vol. 28, No. 6. pp. 893-901.
@article{53bcdf0a38fc432bb97fa20fa5f349b6,
title = "Effects of lactobacillus plantarum and leuconostoc mesenteroides probiotics on human seasonal and Avian Influenza Viruses",
abstract = "Influenza viruses that cause recurrent seasonal epidemics to humans can be controlled with vaccine and antiviral therapy. However, the medical treatments often exhibit limited efficacy in the elderly or immunosuppressed individuals. In these cases, daily uptake of probiotics may be an option to bring in health benefits against influenza. Here, we demonstrate the effects of probiotics Lactobacillus plantarum (Lp) and Leuconostoc mesenteroides (Lm) against seasonal and avian influenza viruses. As assessed by the plaque size reduction of human H1N1 and avian influenza H7N9 viruses, including green fluorescent protein-tagged H1N1 strain in cells, the selected Lp and Lm strains restrained viral replication in mouse lungs with statistical significance. Against lethal viral challenge, the Lp and Lm strains exhibited their beneficial effects by increasing the mean days and rates of survival of the infected mice. These results suggest that, despite rather narrow ranges of protective efficacy, the dietary supplement of Lactobacillus and Leuconostoc probiotics may promote health benefits against influenza.",
keywords = "Dietary supplement, Influenza, Lactobacillus plantarum, Leuconostoc mesenteroides, Probiotic",
author = "Bae, {Joon Yong} and Kim, {Jin Il} and Sehee Park and Kirim Yoo and Kim, {In Ho} and Wooha Joo and Ryu, {Byung Hee} and Park, {Mee Sook} and Ilseob Lee and Man-Seong Park",
year = "2018",
month = "6",
day = "1",
doi = "10.4014/jmb.1804.04001",
language = "English",
volume = "28",
pages = "893--901",
journal = "Journal of Microbiology and Biotechnology",
issn = "1017-7825",
publisher = "Korean Society for Microbiolog and Biotechnology",
number = "6",

}

TY - JOUR

T1 - Effects of lactobacillus plantarum and leuconostoc mesenteroides probiotics on human seasonal and Avian Influenza Viruses

AU - Bae, Joon Yong

AU - Kim, Jin Il

AU - Park, Sehee

AU - Yoo, Kirim

AU - Kim, In Ho

AU - Joo, Wooha

AU - Ryu, Byung Hee

AU - Park, Mee Sook

AU - Lee, Ilseob

AU - Park, Man-Seong

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Influenza viruses that cause recurrent seasonal epidemics to humans can be controlled with vaccine and antiviral therapy. However, the medical treatments often exhibit limited efficacy in the elderly or immunosuppressed individuals. In these cases, daily uptake of probiotics may be an option to bring in health benefits against influenza. Here, we demonstrate the effects of probiotics Lactobacillus plantarum (Lp) and Leuconostoc mesenteroides (Lm) against seasonal and avian influenza viruses. As assessed by the plaque size reduction of human H1N1 and avian influenza H7N9 viruses, including green fluorescent protein-tagged H1N1 strain in cells, the selected Lp and Lm strains restrained viral replication in mouse lungs with statistical significance. Against lethal viral challenge, the Lp and Lm strains exhibited their beneficial effects by increasing the mean days and rates of survival of the infected mice. These results suggest that, despite rather narrow ranges of protective efficacy, the dietary supplement of Lactobacillus and Leuconostoc probiotics may promote health benefits against influenza.

AB - Influenza viruses that cause recurrent seasonal epidemics to humans can be controlled with vaccine and antiviral therapy. However, the medical treatments often exhibit limited efficacy in the elderly or immunosuppressed individuals. In these cases, daily uptake of probiotics may be an option to bring in health benefits against influenza. Here, we demonstrate the effects of probiotics Lactobacillus plantarum (Lp) and Leuconostoc mesenteroides (Lm) against seasonal and avian influenza viruses. As assessed by the plaque size reduction of human H1N1 and avian influenza H7N9 viruses, including green fluorescent protein-tagged H1N1 strain in cells, the selected Lp and Lm strains restrained viral replication in mouse lungs with statistical significance. Against lethal viral challenge, the Lp and Lm strains exhibited their beneficial effects by increasing the mean days and rates of survival of the infected mice. These results suggest that, despite rather narrow ranges of protective efficacy, the dietary supplement of Lactobacillus and Leuconostoc probiotics may promote health benefits against influenza.

KW - Dietary supplement

KW - Influenza

KW - Lactobacillus plantarum

KW - Leuconostoc mesenteroides

KW - Probiotic

UR - http://www.scopus.com/inward/record.url?scp=85049163353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049163353&partnerID=8YFLogxK

U2 - 10.4014/jmb.1804.04001

DO - 10.4014/jmb.1804.04001

M3 - Article

C2 - 29847863

AN - SCOPUS:85049163353

VL - 28

SP - 893

EP - 901

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

SN - 1017-7825

IS - 6

ER -